Depression and Thyrotoxicosis

Hasan, Mohammad Khalid; Mooney, Roger P

doi:10.5915/13-3-11966

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Neuropsychiatric Symptomatology In Thyroid Disease1

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2008

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“…However, overt psychiatric illness only occurs in approximately 10% of thyrotoxic patients (123). Patients developing mania when in a thyrotoxic state commonly have an underlying mood disorder or positive family history (124–126). In hypothyroid patients, depression‐like symptoms including psychomotor retardation, decreased appetite, fatigue, and lethargy often occur (127).…”

Section: Neuropsychiatric Symptomatology In Thyroid Diseasementioning

confidence: 99%

The Thyroid‐Brain Interaction in Thyroid Disorders and Mood Disorders

Bauer

Goetz

Glenn³

et al. 2008

J Neuroendocrinology

339

230

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Thyroid hormones play a critical role in the metabolic activity of the adult brain, and neuropsychiatric manifestations of thyroid disease have long been recognised. However, it is only recently that methodology such as functional neuroimaging has been available to facilitate investigation of thyroid hormone metabolism. Although the role of thyroid hormones in the adult brain is not yet specified, it is clear that without optimal thyroid function, mood disturbance, cognitive impairment and other psychiatric symptoms can emerge. Additionally, laboratory measurements of peripheral thyroid function may not adequately characterise central thyroid metabolism. Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.

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Section: Neuropsychiatric Symptomatology In Thyroid Diseasementioning

confidence: 99%