2016
DOI: 10.1001/jamaoto.2015.3171
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Depression and Survival in Patients With Head and Neck Cancer

Abstract: An association between depression and survival in patients with HNC is apparent; however, the strength and etiology of this association is not yet clear. Further directed and multi-institutional study is required to investigate this association and determine appropriate screening and management strategies.

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Cited by 67 publications
(55 citation statements)
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“…Patients who underwent surgery had a markedly greater risk for the development of depressive disorders and were at increased risk of a first depressive episode than those who received RTX and/or CTX. Prior studies in other cancers have noted a similar increased risk of depression after cancer treatment . This increased risk of depression after surgery may be attributed to not only the physical and mental demands of undergoing surgical treatment but also to the lack of proper screening and counseling before depression onset .…”
Section: Discussionmentioning
confidence: 99%
“…Patients who underwent surgery had a markedly greater risk for the development of depressive disorders and were at increased risk of a first depressive episode than those who received RTX and/or CTX. Prior studies in other cancers have noted a similar increased risk of depression after cancer treatment . This increased risk of depression after surgery may be attributed to not only the physical and mental demands of undergoing surgical treatment but also to the lack of proper screening and counseling before depression onset .…”
Section: Discussionmentioning
confidence: 99%
“…The incidence of depression among patients with HNC may be as high as 40%. The authors found a significant decrease in survival in depressed patients in two of the three studies that met their inclusion criteria . Furthermore, patients with HNC have more than 3 times the incidence of suicide compared with the general US population.…”
Section: Introductionmentioning
confidence: 95%
“…The authors found a significant decrease in survival in depressed patients in two of the three studies that met their inclusion criteria. 39 Furthermore, patients with HNC have more than 3 times the incidence of suicide compared with the general US population. Suicide rates were highest among those with cancers of the larynx and hypopharynx in a 2015 study.…”
Section: Sufferingmentioning
confidence: 99%
“…15 In many studies, depression is associated with shorter survival in cancer patients, both as a result of death by cancer and death by other causes, although conflicting results exist. [16][17][18] Lower survival in patients with depression is partly explained by their poorer adherence to cancer treatment, 19 poorer self-care (e.g., an unfavorable life-style such as decreased levels of physical exercise 20 and higher alcohol and tobacco consumption), 21 and consenting to medical decisions which may shorten life (e.g., receiving chemotherapy at the very end of life, which can adversely affect survival). 22 In clinical settings, patients with depression tend to stay longer in hospital.…”
Section: Impact Of Depressionmentioning
confidence: 99%