Depression and Suicidal Behavior in Acne Patients Treated With Isotretinoin: A Systematic Review

Marqueling, Ann L.; Zane, Lee T.

doi:10.1016/j.sder.2008.03.005

Cited by 117 publications

(78 citation statements)

References 42 publications

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“…Nonetheless, patients must be made aware of this possibility and treating physicians should monitor patients for psychiatric adverse effects. [159][160][161][162][163][164][165] Some patients experience a relapse of acne after the first course of treatment with isotretinoin. The panel feels relapses are more common in younger adults or when lower doses are used.…”

Section: Adverse Effectsmentioning

confidence: 99%

Guidelines of care for acne vulgaris management

Strauss

Krowchuk

Leyden

et al. 2007

Journal of the American Academy of Dermatology

427

347

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Section: Adverse Effectsmentioning

confidence: 99%

Guidelines of care for acne vulgaris management

Strauss

Krowchuk

Leyden

et al. 2007

Journal of the American Academy of Dermatology

427

347

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“…However, there are many studies demonstrating positive and negative correlation between isotretinoin use and increased risk of depression [108][109][110][111][112]. Nevertheless, given the serious nature of depression and suicidal ideation, close psychological monitoring of patients is recommended.…”

Section: Isotretinoinmentioning

confidence: 99%

Acne Vulgaris

Kutlubay¹,

Keçici²,

Engın³

et al. 2017

Acne and Acneiform Eruptions

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Acne vulgaris is a multifactorial disorder of the pilosebaceous unit. The clinical picture can range from mild comedones to fulminant, scarring cases. Approximately 83-100% of all adolescents experience acne vulgaris at some point of their lives. Although acne often tends to resolve following the adolescent period, many men and women continue to suffer from either active acne or postinflammatory scars into their twenties and thirties. Most patients with acne vulgaris are in the complicated adolescence period and thus carry a distinctive psychosocial burden. They possess a disease stigma on their skin for the external world to criticize every day. For all these reasons, acne is a disease which should be treated promptly and efficiently in all age groups. This chapter will provide a comprehensive and up-to-date review of pathophysiology of acne vulgaris, new molecular mechanisms on the evolving acne lesions, epidemiology of the disease, and latest treatment options. The molecular biology of acne lesions, novel treatment options including cosmetic approaches, their role in acne pathogenesis, pathophysiology, and mechanism of actions of the drugs, safety, and efficacy issues, and various treatment regimens will be discussed along with novel discoveries and areas in which further research is needed.

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“…Hence combination of systemic and topical agents is recommended in severe cases (4,5). Oral Isotretinoin is the main choice of treatment in severe cases yet side effects like dyslipidemia and dry mucous membranes are usually considered (6,7). In Iranian traditional medicine (ITM), skin and nervous system have the same origin.…”

Section: Contextmentioning

confidence: 99%

A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

et al. 2016

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Context: Iranian traditional medicine (ITM) is based on humoral theory. Temperament or Mizaj is the result of a combination of four cardinal humors. They are blood, phlegm, yellow bile (Safra) and black bile (melancholy). Like any other disease, acne is the result of humoral imbalance. Acne is a highly prevalent dermatologic problem, which has both physical and psychological effects. The aim of this study was to introduce the etiology of acne and its remedies from the perspective of ITM. Evidence Acquisition: Etiology and treatment of acne were studied and analyzed from selected medical textbooks of ITM. Some of the effective plants in these books were assessed in a table, and their anti-acne activities were compared with conventional medicine's database. Results: From the perspective of ITM, considering six essential schemes for health, diet and herbal remedies as well as manipulation are recommended for acne treatment. Although the introduced plants have antibacterial, anti-inflammatory and antioxidant effects but some of them have special proven effects on acne formation process. There is also a strong relationship between digestive system and skin. Conclusions: This paper was rendered to show ancient Persian scholar's point of view about acne and its treatment, and it was shown that Iranian traditional medicine has practical recommendations for acne treatment.Keywords: Acne, Iranian Traditional Medicine, Diet, Herbal Remedies, Digestivesystem ContextAcne is a common dermatological disease highly prevalent in the age group of 12 to 25 years. It affects patients both physically and psychologically, resulting impaired psychosocial development, reduced self-esteem and emotional distress due to perceived disfigurement (1). Acne vulgaris is diagnosed by variable clinical manifestations such as white or black comedones, papules and pustules. Acne scarring is the sequel of severe cases (2). The etiology of this problem involves high sebum secretion, bacterial infection, hyperkeratinisation as well as hormonal change in the body (3). Reducing scars and erythematous lesions is the aim of treatment. Hence combination of systemic and topical agents is recommended in severe cases (4, 5). Oral Isotretinoin is the main choice of treatment in severe cases yet side effects like dyslipidemia and dry mucous membranes are usually considered (6, 7). In Iranian traditional medicine (ITM), skin and nervous system have the same origin. Skin can represent internal organs function and its duty is to protect human body from external stressors (8). Body temperature regulation is another crucial task performed by the skin in human body and small pores in the skin play important roles regarding this ability. In addition to this, skin has an ability to secrete surplus substances in different forms of discharges, and acne formation could be the result of this phenomena. According to the theory of humors in ITM, dystemperament or "Suemizaj" may occur when there is an imbalance in humoral quantity or quality (9). This humoral imbalan...

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Depression and Suicidal Behavior in Acne Patients Treated With Isotretinoin: A Systematic Review

Cited by 117 publications

References 42 publications

Guidelines of care for acne vulgaris management

Guidelines of care for acne vulgaris management

Acne Vulgaris

A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

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