Depression and Stress Reactivity in Metastatic Breast Cancer

Giese‐Davis, Janine; Wilhelm, Frank H.; Conrad, Ansgar; Abercrombie, Heather C.; Sephton, Sandra E.; Yutsis, Maya; Neri, Eric; Taylor, C. Barr; Kraemer, Helena C.; Spiegel, David

doi:10.1097/01.psy.0000238216.88515.e5

Cited by 103 publications

(79 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One large and heterogeneous diagnostic category, depression, has produced conflicting results with regard to the CAR: some studies described a blunted CAR in patients with depression (Stetler and Miller, 2005;Huber et al, 2006), in metastatic breast cancer patients with depression (Giese- Davis et al, 2006) or in subjects with cognitive vulnerability markers of depression (self-focused rumination, Kuehner et al, 2007), and others reported an increased CAR in depressed patients (Bhagwagar et al, 2005) or individuals with self-reported depressive symptoms (Pruessner et al, 2003). As depression is a very heterogeneous diagnostic group, it seems very likely that different subtypes (e. g. atypical vs. melancholic depression) have to be considered separately to obtain consistent results (see also Gold and Chrousos, 2002).…”

Section: Factors That Influence the Carmentioning

confidence: 98%

The cortisol awakening response (CAR): Facts and future directions

Fries

Dettenborn

Kirschbaum

2009

International Journal of Psychophysiology

1,015

874

View full text Add to dashboard Cite

Section: Factors That Influence the Carmentioning

confidence: 98%

The cortisol awakening response (CAR): Facts and future directions

Fries

Dettenborn

Kirschbaum

2009

International Journal of Psychophysiology

1,015

874

View full text Add to dashboard Cite

“…For each 5-min segment, five 1-min averages of HR extracted by the VivoLogic software were averaged. For the HRV measures, the ECG and respiration signals for each of the 5-min segments were imported into customized programs (for details, see Giese-Davis et al, 2006) and edited for artifacts. The variance in the RR-interval signal was decomposed via spectral analysis to yield a set of frequency domain indices representing the spectral power within distinct frequency bands [HF (0.13 -0.5 Hz), LF (0.04 -0.13 Hz), and VLF (0.003 -0.04 Hz)].…”

Section: Physiological Measuresmentioning

confidence: 99%

Circadian affective, cardiopulmonary, and cortisol variability in depressed and nondepressed individuals at risk for cardiovascular disease

Conrad

Wilhelm

Roth

et al. 2008

Journal of Psychiatric Research

Self Cite

View full text Add to dashboard Cite

Depression is a risk factor for cardiovascular disease (CVD) perhaps mediated by hypothalamicpituitary-adrenal (HPA) axis or vagal dysregulation. We investigated circadian mood variation and HPA-axis and autonomic function in older (≥55 years) depressed and nondepressed volunteers at risk for CVD by assessing diurnal positive and negative affect (PA, NA), cortisol, and cardiopulmonary variables in 46 moderately depressed and 19 nondepressed volunteers with elevated CVD risk. Participants sat quietly for 5-min periods (10:00, 12:00, 14:00, 17:00, 19:00, 21:00), and then completed an electronic diary assessing PA and NA. Traditional and respiration-controlled heart rate variability (HRV) variables were computed for these periods as an index of vagal activity. Salivary cortisols were collected at waking, waking+30 min, 12:00, 17:00, and 21:00 hours. Cortisol peaked in the early morning after waking, and gradually declined over the day, but did not differ between groups. PA was lower and NA was higher in the depressed group throughout the day. HRV did not differ between groups. Negative emotions were inversely related to respiratory sinus arrhythmia in nondepressed participants. We conclude that moderately depressed patients do not show abnormal HPA-axis function. Diurnal PA and NA distinguish depressed from nondepressed patients at risk for CVD, while measures of vagal regulation, even when controlled for physical activity and respiratory confounds, do not. Diurnal mood variations of older individuals at risk for CVD differ from those reported for other groups and daily fluctuations in NA are not related to cardiac autonomic control in depressed individuals. KeywordsCardiovascular Disease; Cortisol; Depression; Heart Rate Variability Depression has a major impact on mortality, morbidity, and functional recovery in patients with cardiovascular disease (CVD) (Carney, Freedland, & Sheps, 2004). Several mechanisms have been proposed to explain how depression might increase CVD risk, including Corresponding Author: Frank H. Wilhelm, Ph.D.; Tel.: ++41-61-267 0593; Fax: ++41-61-267 0659; E-mail: frank.wilhelm@unibas.ch; Address: Institute for Psychology, University of Basel, Missionsstrasse 60/62, CH-4055 Basel, Switzerland. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (Musselman, Evans, & Nemeroff, 1998). Abnormal HPA-axis function may contribute to CVD risk through a variety of related risk factors, including hypertension, high lipids, insulin resistance, and abdominal obesity, together constituting the metabolic syndrome (Brown, Varghese, & McEwen, 2004). Several stu...

show abstract

“…Flatter daytime slopes of cortisol have been associated with fatigue in breast cancer patients [14,15] and were predictive of earlier mortality with metastatic breast cancer [16], independent of other known prognostic factors. In addition, depression was associated to blunted stress reactivity in metastatic breast cancer [17]. Recent work suggested that flatter daytime cortisol slopes among metastatic breast cancer patients may be related to disrupted feedback inhibition of the HPA axis rather than hypersensitivity in response to stimulation [18].…”

Section: Introductionmentioning

confidence: 98%