Depression and Sleep-Related Symptoms in an Adult, Indigenous, North American Population

Froese, Colleen; Butt, Abdalla; Mulgrew, Alan; Cheema, Rupi; Speirs, Mary-Ann; Gosnell, Carmen; Fleming, J. E. E.; Fleetham, John A.; Ryan, C. Frank; Ayas, Najib

doi:10.5664/jcsm.27237

Cited by 67 publications

(38 citation statements)

References 18 publications

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“…Urinary symptoms are common NMSs that cause discomfort and an unpredictable need to use the bathroom at night and may contribute to disrupted sleep. Our findings confirm that depression and anxiety are the main determinants of sleep quality, which is in line with several previous studies that reported that depression was the main determinant of sleep disorders (32)(33)(34)(35). The effects of these symptoms on sleep in PD patients have not been fully examined.…”

Section: Discussionsupporting

confidence: 88%

Nonmotor Symptoms Affect Sleep Quality in Early-Stage Parkinson's Disease Patients With or Without Cognitive Dysfunction

et al. 2020

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Purpose: Parkinson's disease (PD) patients frequently present with sleep disorders. This study was designed to assess the impact of nonmotor symptoms (NMSs) on sleep quality in early-stage PD patients with and without cognitive dysfunction. Materials and Methods:A sample of 389 early-stage PD patients (modified Hoehn and Yahr score ≤2.5, duration ≤5 years) was recruited for the present study. The Non-Motor Symptoms Questionnaire (NMS-Quest) was used to screen for global NMSs. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HAMD). PD motor symptoms were measured with the Unified PD Rating Scale (UPDRS), part III. The Montreal Cognitive Assessment (MoCA) was used to evaluate global cognitive status, and the PD Sleep Scale (PDSS) was used to quantify sleep quality. Polysomnography (PSG) was used for objective assessment of sleep.Results: In our sample, approximately one-quarter of the PD patients suffered from sleep disturbances (23.7%). Our results also confirmed the high prevalence of cognitive dysfunction in patients with PD (39.8%). In patients with cognitive dysfunction, higher percentage of sleep disorders (34.8 vs. 16.2%, P < 0.01) was observed. They also with lower PDSS score, sleep efficiency (SE) and longer sleep lantency (SL) and wake after sleep onset (WASO) (All P < 0.05). In total, the patients who suffered from NMSs, such as depressive symptoms, anxiety symptoms, urinary tract symptoms and hallucinations/delusions, had poorer sleep quality. Better cognition may predict better sleep quality. In patients with cognitive dysfunction, the NMS-Hallucinations/delusions score was the most important risk factor for sleep disorders. In patients without cognitive dysfunction, NMSs such as anxiety and cognition and medication were related to sleep disorder. Conclusions:NMSs in early-stage PD are highly associated with and are determinants of subjective sleep quality. Future studies should focus on elucidating the pathophysiology of these symptoms.

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Section: Discussionsupporting

confidence: 88%

Nonmotor Symptoms Affect Sleep Quality in Early-Stage Parkinson's Disease Patients With or Without Cognitive Dysfunction

et al. 2020

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“…Some of the studies found higher Epworth Sleepiness Scale (ESS) scores in subjects with RLS, whereas other failed to identify such findings. [12][13][14][15][16][17][18] The aim of this study was to explore the association of EDS with SDB and RLS in acute ischemic stroke. An extensive literature search did not reveal any study on this topic.…”

mentioning

confidence: 99%

Excessive Daytime Sleepiness in Acute Ischemic Stroke: Association With Restless Legs Syndrome, Diabetes Mellitus, Obesity, and Sleep-Disordered Breathing

Šiarnik

Klobučníková

Šurda

et al. 2018

Journal of Clinical Sleep Medicine

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“…The British Society of Sexual Medicine Guidelines [8] reports a prevalence ranging from 10 to 52% from several large studies, with a steep age-related increase. ED shares many associated physical conditions with OSA and both have also been demonstrated to affect psychosocial health [4][5][6][8][9][10][11].…”

Section: Journal Of Sleep Disorders and Therapy Review Articlementioning

confidence: 99%

“…It is estimated that the worldwide prevalence is between 9 and 38% [2], however the prevalence in the UK is thought to be just 4% [3]. Patients with OSA have reported increased fatigue, poor quality of life, deterioration of personal relationships, and reduced libido [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

Polson¹,

Ralph²,

Kalejaiye³

2019

J Sleep Disord Ther

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Erectile dysfunction (ED) and obstructive sleep apnoea (OSA) are increasingly common conditions seen in primary and secondary care. With shared risk factors and associated comorbidities men often suffer with both. The aim of this study is to review the literature to consider why there is a correlation, and clinically how assessment and management of such patients could be adjusted. A structured review of current literature was performed using search terms 'erectile dysfunction' or 'erectile function' or 'Erection' or 'Sexual dysfunction' AND 'Sleep apnoea/apnea' or 'sleep disorder'. Descriptive analysis categorized results into: The association between OSA and ED; the pathophysiological hypotheses; the role of OSA treatment; and the role of ED treatment. Higher prevalence of ED in patients with OSA is demonstrated, particularly in men with more severe OSA disease, reaching 80% in some studies. However, the pathophysiological explanation remains unclear with a number of hypotheses researched. CPAP is the mainstay of treatment for OSA, and short and long-term benefits to sexual function are demonstrated in men with severe OSA from it's use. Further improvement in ED and quality of life can be achieved by additional PDE5 inhibitor therapy. With the increasing evidence base showing higher rates of ED in OSA patients there is certainly a role for clinicians in both OSA and ED clinics to enquire about each condition. A referral to their counterpart for consideration of combination treatment with CPAP and a PDE5 inhibitor for both of these problematic, life changing diseases is recommended-particularly in those with severe disease. Further investigation is needed to try and establish any pathophysiological link, and the impact of treatment in less severe cases.

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Depression and Sleep-Related Symptoms in an Adult, Indigenous, North American Population

Cited by 67 publications

References 18 publications

Nonmotor Symptoms Affect Sleep Quality in Early-Stage Parkinson's Disease Patients With or Without Cognitive Dysfunction

Nonmotor Symptoms Affect Sleep Quality in Early-Stage Parkinson's Disease Patients With or Without Cognitive Dysfunction

Excessive Daytime Sleepiness in Acute Ischemic Stroke: Association With Restless Legs Syndrome, Diabetes Mellitus, Obesity, and Sleep-Disordered Breathing

Erectile Dysfunction and Obstructive Sleep Apnoea-What is the Link and What can We do about it? A Descriptive Review of the Current Literature

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