Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension

Abramson, Jerome L.; Berger, Alan K.; Krumholz, Harlan M.; Vaccarino, Viola

doi:10.1001/archinte.161.14.1725

Cited by 188 publications

(136 citation statements)

References 27 publications

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“…However, in a multivariable model, psychosocial factors were stronger risk factors for incident MI than diabetes, smoking, hypertension, and obesity. 10 Depression has also been associated with the development of congestive heart failure (CHF) 11,12 and with adverse outcomes in patients with CHF. [13][14][15] In a study examining incidence of CHF among 4500 patients who were enrolled in the Systolic Hypertension in the Elderly Program, the cumulative incidence of CHF in the depressed patients was 16%, whereas the incidence was only 7% in the nondepressed group.…”

Section: Did Depression Increase This Patient's Risk For a Recurrent mentioning

confidence: 99%

“…[13][14][15] In a study examining incidence of CHF among 4500 patients who were enrolled in the Systolic Hypertension in the Elderly Program, the cumulative incidence of CHF in the depressed patients was 16%, whereas the incidence was only 7% in the nondepressed group. 11 This resulted in an overall relative risk of 2.6 after adjustment for traditional cardiovascular risk factors. In patients with established CHF, depression further predicts mortality and rehospitalization, independent of baseline ventricular function and severity of cardiovascular disease.…”

Section: Did Depression Increase This Patient's Risk For a Recurrent mentioning

confidence: 99%

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Depression and Cardiovascular Disease

Whooley¹

2006

JAMA

218

163

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Major depressive disorder is a risk factor for the development of incident coronary heart disease events in healthy patients and for adverse cardiovascular outcomes in patients with established heart disease. Depression is present in 1 of 5 outpatients with coronary heart disease and in 1 of 3 outpatients with congestive heart failure, yet the majority of cases are not recognized or appropriately treated. It is not known whether treating depression improves cardiovascular outcomes, but antidepressant treatment with selective serotonin reuptake inhibitors is generally safe, alleviates depression, and improves quality of life. This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder. CASE PRESENTATIONA 58-year-old man with a history of coronary heart disease (CHD), type 2 diabetes mellitus, hypertension, smoking, and alcohol dependence presented for routine medical care. He had initially sought medical attention for exertional angina 5 years previously, at which time he underwent exercise treadmill testing with thallium that was positive for reversible perfusion defects in the anterior, septal, and inferior walls. Subsequent coronary angiography revealed diffuse heavy calcifications in the left anterior descending artery with a moderate lesion prior to the first diagonal. Several major septal perforators had significant lesions at their origins. In the dominant right coronary artery, there were diffuse calcifications but no significant lesions. The left circumflex and large ramus intermedius were free of discrete lesions. Left ventricular function was normal.The patient underwent single-vessel (left internal mammary artery to left anterior descending artery) coronary artery bypass grafting (CABG) surgery. He was prescribed atenolol 100 mg/ d, lisinopril 40 mg/d, lovastatin 80 mg/d, aspirin 325 mg/d, metformin 850 mg 3 times a day, and glipizide 10 mg 2 times a day. Despite being nonadherent to his prescribed medications, he remained stable for 5 years, but then one day, while doing household chores, he suddenly developed chest pressure, shortness of breath, and diaphoresis that lasted 12 hours. On admission to the hospital his troponin I was elevated and peaked at 0.7 ng/mL (normal, <0.05 ng/mL), consistent with a myocardial infarction (MI). His electrocardiogram had not changed.

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Section: Did Depression Increase This Patient's Risk For a Recurrent mentioning

confidence: 99%

Section: Did Depression Increase This Patient's Risk For a Recurrent mentioning

confidence: 99%

Depression and Cardiovascular Disease

Whooley¹

2006

JAMA

218

163

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“…[38][39][40][41][42] Anxiety and depression have been associated with increased risk of cardiovascular disease and are common in those with established cardiovascular disease; their added presence in established cardiovascular disease confers a poorer prognosis. 40,41,[43][44][45][46][47][48] There is a growing body of research which describes the mechanisms of mind-heart interactions. The autonomic nervous system is one of the principal components of the mindheart connection and is one of the fundamental links between thoughts and emotions and the heart.…”

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confidence: 99%

Meditation: Should a cardiologist care?

Olex

Newberg

Figueredo

2013

International Journal of Cardiology

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“…[4][5][6][7] With the advent of effective antiretroviral therapies, HIV has shifted from being a disease of recurring opportunistic infections to a chronic disorder complicated by multiple noninfectious comorbidities, not the least of which is cardiovascular disease. 8 To improve outcomes among the large cohort of people infected with HIV, it is important to identify potentially modifiable cardiovascular and noncardiovascular risk factors for diseases such as HF that affect quality and quantity of life.…”

Section: Article See P 1630mentioning

confidence: 99%