Depression and quality of life issues in patients with amyotrophic lateral sclerosis

Stromberg, Shannon F.; Weiss, David B.

doi:10.1007/s11940-006-0030-x

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…This fact agrees with already published data that found 44-75% of their ALS patients exhibited significant signs and symptoms of depression [24][25][26]. Prevalence of depression was not different between invasively ventilated and non-ventilated patients or between IV and NIV patients, a fact that is coherent with Kübler et al [27].…”

Section: Discussionsupporting

confidence: 92%

Quality of life of ALS and LIS patients with and without invasive mechanical ventilation

et al. 2011

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There are very few studies where quality of life (QOL) is assessed in patients with complete physical and functional disability and dependence to invasive mechanical ventilation (IV). We compared QOL of amyotrophic lateral sclerosis (ALS) and locked-in-syndrome (LIS) patients with invasive mechanical ventilation to ALS and LIS patients without mechanical invasive ventilation. Thirty-four patients, 27 with ALS and seven with LIS (vascular or tumoral aetiology) were included in the study. Twelve had invasive ventilation, 22 had non-invasive ventilation, and in the non-invasive ventilation group, five of them had ventilation via mask. The following scales were used for patients: ALS Functional Rating Scale (ALSFRS), McGILL, Short-Form 36 (SF36), Beck Depression Inventory-II, the Toronto Alexithymia Scale and the anxiety inventory of Spielberger. Mean ALSFRS scores were significantly lower in the invasive ventilation group (IV) than in the non-invasive ventilation group. McGILL and SF36 were not significantly different between the IV group and the non-invasive ventilation group; there were no significant differences between the two groups for others scales either. Comparison between IV group and LIS without invasive mechanical ventilation revealed no significant difference for SF36 and McGILL QOL scores. QOL was not significantly different between the IV and not invasively ventilated patients, but ALSFRS was significantly lower in the IV group, and comparison of QOL scores between non-ventilated LIS patients who had the same score of dependence that invasively ventilated patients did not show any difference. Invasive mechanical ventilation for patients who accept tracheotomy allows life prolongation and their QOL is not affected; medical teams should be aware of that.

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Section: Discussionsupporting

confidence: 92%

Quality of life of ALS and LIS patients with and without invasive mechanical ventilation

et al. 2011

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“…Furthermore, 15% of them had severe depressive symptoms. 48 , 49 Prevalence of depression does not show differences between invasively ventilated and nonventilated patients or between IV and NIV patients. This data is coherent with Kübler et al 50 and Hazenberg et al 51 who indicated that in some patients with ALS, QoL did not improve after 6 months of NIV.…”

Section: Interface For Continuous Nivmentioning

confidence: 98%

Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives

Fiorentino

Annunziata

Gaeta

et al. 2018

DNND

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Respiratory failure is a recognized late complication of amyotrophic lateral sclerosis. It is related to the neurological progression of the diseases with the impairment of the respiratory musculature. Survival and quality of life of amyotrophic lateral sclerosis patients is improved by using noninvasive mechanical ventilation. The rate of long-term mechanical ventilation is different within and between countries. Cultural factors, socioeconomic conditions, and physician attitude often influence the decision to start noninvasive ventilation. Technical elements, like the choice of the correct interface, solid caregivers support, and the communication between the patient and the physician are essential for achieving therapeutic goals, especially in the case of continuous treatment.

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“…The occurrence of PBA has been reported in a multitude of neurologic illnesses including, but not limited to, ALS, [15][16][17][18][19] PD and other movement disorders, 13,[20][21][22] MS, [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] stroke, [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] various types of dementia and other neurodegenerative disorders, 55-62 traumatic brain injury (TBI), 63-66 central nervous system tumors, [67][68][69][70][71][72][73][74]...…”

Section: Epidemiologymentioning

confidence: 99%

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

King¹,

Reiss²

2013

DNND

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Pseudobulbar affect is a disorder resulting from neurologic damage manifesting as sudden, stereotyped affective outbursts that are not reflective of internal emotion. A literature review was completed to examine the current understanding of the epidemiology, characterization, diagnosis, pathophysiology, and treatment of pseudobulbar affect. This review revealed that it is common in neurodegenerative disorders but is poorly recognized, placing significant impacts on patients and their families. The disorder appears to result from a disruption of the cortico-limbicsubcortical-thalamic-pontocerebellar network involved in emotional expression and regulation with resulting disruptions of neurotransmitter systems. Effective treatment is available with agents such as selective serotonin reuptake inhibitors and dextromethorphan combined with quinidine, but further well-designed comparative studies are needed. Advances in technology such as neuroimaging may enhance knowledge about the pathophysiology of this disorder, and help guide future interventions.

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Depression and quality of life issues in patients with amyotrophic lateral sclerosis

Cited by 7 publications

References 34 publications

Quality of life of ALS and LIS patients with and without invasive mechanical ventilation

Quality of life of ALS and LIS patients with and without invasive mechanical ventilation

Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

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