Depression and Parkinson’s Disease: Current Knowledge

Marsh, Laura

doi:10.1007/s11910-013-0409-5

Cited by 296 publications

(287 citation statements)

References 99 publications

(109 reference statements)

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“…36 Patients with neurodegenerative disease that affects the OFC (such as behavioral variant frontotemporal dementia) usually demonstrate a syndrome of poor decision making and impulsivity similar to the externalizing factor detected in the current study, in addition to emotional blunting. 37 In contrast, patients with subcortical neurodegeneration that initially spares the OFC (such as Huntington's and Parkinson's diseases) will usually manifest internalizing symptoms of depression, irritability, and anxiety, 38,39 suggesting that a functioning OFC is necessary both for the normal experience of emotion and the pathological experience of excessive emotion including depression and anxiety. Factor scores best predicted left amygdala and bilateral hippocampal involvement, whereas DSM diagnoses were associated with bilateral basal ganglia and left OFC involvement.…”

Section: Discussionmentioning

confidence: 99%

Brain Regions Associated With Internalizing and Externalizing Psychiatric Symptoms in Patients With Penetrating Traumatic Brain Injury

Huey¹,

Lee²,

Lieberman³

et al. 2016

JNP

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A factor structure underlying DSM-IV diagnoses has been previously reported in neurologically intact patients. The authors determined the brain regions associated with factors underlying DSM-IV diagnoses and compared the ability of DSM-IV diagnoses, factor scores, and self-report measures to account for the neuroanatomical findings in patients with penetrating brain injuries. This prospective cohort study included 254 Vietnam War veterans: 199 with penetrating brain injuries and 55 matched control participants. Measures include DSM-IV diagnoses (from a Structured Clinical Interview for DSM), self-report measures of depression and anxiety, and CT scans. Factors underlying DSM-IV diagnoses were determined using an exploratory factor analysis and correlated with percent of brain regions affected. The ability of the factor scores, DSM-IV diagnoses, and the self-report psychiatric measures to account for the anatomical variance was compared with multiple regressions. Internalizing and externalizing factors were identified in these brain-injured patients. Damage to the left amygdala and bilateral basal ganglia was associated with lower internalizing factor scores, and damage to the left medial orbitofrontal cortex (OFC) with higher, and bilateral hippocampi with lower, externalizing factor scores. Factor scores best predicted left amygdala and bilateral hippocampal involvement, whereas DSM-IV diagnoses best predicted bilateral basal ganglia and left OFC involvement. Damage to the limbic areas involved in the processing of emotional and reward information, including structures involved in the National Institute of Mental Health's Research Domain Criteria Negative Valence Domain, influences the development of internalizing and externalizing psychiatric symptoms. Self-report measures underperformed DSM-IV and factor scores in predicting neuroanatomical findings. DSM is a classification system of psychiatric disorders based on the clustering of psychiatric symptoms in patients as observed by clinicians.1 There is a growing body of evidence, however, that a factor structure underlies, and can cut across, DSM diagnoses. 2-4 It has been hypothesized, but not yet tested, that these factors underlying DSM diagnoses will be more closely associated with the neuroanatomical bases of psychiatric symptoms than DSM diagnosis. In the current study, we determined the factor structure of psychopathology underlying the DSM diagnoses of 199 Vietnam War veterans who suffered penetrating brain injuries and 55 matched control participants. We then determined which neuroanatomical structures, when damaged, were associated with higher or lower factor scores compared with participants without damage to that structure. We also compared the ability of DSM-IV categorical diagnoses, factors derived from DSM-IV diagnoses, and continuous self-report measures of depressive and anxiety symptoms to predict the neuroanatomical findings. This study had two goals: 1) to determine which specific brain regions are associated with core components of psychopa...

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Section: Discussionmentioning

confidence: 99%

Brain Regions Associated With Internalizing and Externalizing Psychiatric Symptoms in Patients With Penetrating Traumatic Brain Injury

Huey¹,

Lee²,

Lieberman³

et al. 2016

JNP

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“…However, the reductionism of Combe's distinction clearly emerges from the clinical observation given that a wide range of nervous system's illnesses with different etiology shows both neurological and psychiatric symptoms. Emotional and behavioral disturbances with a polymorphic symptomatology are often connected to neurological disorders such as Multiple Sclerosis (MS) [1][2][3] , Parkinson' s Disease (PD) [4] , stroke [5] , dementia [6] , traumatic brain injury [7] , epilepsy [8,9] , Amyotrophic Lateral Sclerosis (ALS) and others Motor Neuron Diseases (MND) [10,11] , pain syndromes (like headaches) and can be observed even with or without "organic" neurological diseases, thus miming in some cases an idiopathic psychiatric disorder.…”

Section: Neurology and Psychiatrymentioning

confidence: 99%

“…Improved mood, better relaxation, increased motor activity in music listening group (P < 0.0001) Kim et al [76] CCT (0) [78] CCT (0) Reduction of depression (P = 0.002) and fatigue (P = 0.02) and improvement in the synchronization tapping (P < 0.05) 1 Subjects expressing a clear preference for treatment (25% of total) were allocated to music therapy while all others were randomly assigned to either treatment or control group; 2 The goal of random assignment was not fully achieved because of the need to have 2-3 subject available at the same time to held group session in the treatment condition; 3 Subjects heard 1 min of music or noise and after were given all assessments while they were continuously exposed to the sound up to the end of the evaluation; 4 Patients were quasi-randomly assigned to groups making sure that the two groups were as close as possible in terms of numerosity and clinical characteristics of participants. …”

Section: Analysis Of Patient's Interviewsmentioning

confidence: 99%

Effects of music and music therapy on mood in neurological patients

Raglio

Attardo

Gontero

et al. 2015

WJP

159

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Mood disorder and depressive syndromes represent a common comorbid condition in neurological disorders with a prevalence rate that ranges between 20% and 50% of patients with stroke, epilepsy, multiple sclerosis, and Parkinson's disease. Notwithstanding, these conditions are often under-diagnosed and under-treated in the clinical practice and negatively affect the functional recovery, the adherence to treatment, the quality of life, and even the mortality risk. In addition, a bidirectional association between depression and neurological disorders may be possible being that depressive syndromes may be considered as a risk factor for certain neurological diseases. Despite the large amount of evidence regarding the effects of music therapy (MT) and other musical interventions on different aspects of neurological disorders, no updated article reviewing outcomes such as mood, emotions, depression, activity of daily living and so on is actually available; for this reason, little is known about the effectiveness of music and MT on these important outcomes in neurological patients. The aim of this article is to provide a narrative review of the current literature on musical interventions and their effects on mood and depression in patients with neurological disorders. Searching on PubMed and PsycInfo databases, 25 studies corresponding to the inclusion criteria have been selected; 11 of them assess the effects of music or MT in Dementia, 9 explore the efficacy on patients with Stroke, and 5 regard other neurological diseases like Multiple Sclerosis, Amyotrophic Lateral Sclerosis/motor neuron disease, Chronic quadriplegia, Parkinson's Disease, and Acquired Brain dysfunctions. Selected studies are based on relational and rehabilitative music therapy approaches or concern music listening interventions. Most of the studies support the efficacy of MT and other musical interventions on mood, depressive syndromes, and quality of life on neurological patients.

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“…Depression is common in neurodegenerative diseases, affecting 30 to 50% of patients in Parkinson's disease [1,2], up to 50% in Alzheimer's disease [3], and 25 to 50% in multiple sclerosis [2,4]. …”

Section: Introductionmentioning

confidence: 99%

The Use of Antidepressant Medication before and after the Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Cohort Study

et al. 2015

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Background: The prevalent use of antidepressants (ATDs) in patients with Amyotrophic Lateral Sclerosis (ALS) varies across cross-sectional and clinic-based published studies. This population-based cohort study assesses the real-world prevalence of the use of ATDs, its trajectory and the association of incident use with clinical characteristics. Methods: All patients with incident ALS in the Friuli Venezia Giulia region, Italy, from 2002 to 2009, were identified through multiple sources including health databases. Diagnosis was validated through clinical documentation review. ATDs prescriptions from 2000 to 2011 were obtained from regional database. The trajectory was estimated through generalized estimating equations for repeated measures logistic regression and the Hazard ratio (HR) of initiating ATDs through multivariate proportional hazard Cox regression. Results: In this cohort of 261 ALS cases, age-, sex-adjusted prevalence of the use of ATDs was 37.3%, higher than in general population. The trajectory increased by 16% in 1-year period across diagnosis. Age ≤67 years at diagnosis (HR 1.28, 95% CI 0.84-1.95) and bulbar onset (1.43, 95% CI 0.90-2.26) were positively associated with initiating ATDs after diagnosis. Conclusions: More than one-third of patients used ATDs. Depression may occur more frequently than previously reported. Depression may precede motor alterations and be related to both ALS diagnosis and progression.

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Depression and Parkinson’s Disease: Current Knowledge

Cited by 296 publications

References 99 publications

Brain Regions Associated With Internalizing and Externalizing Psychiatric Symptoms in Patients With Penetrating Traumatic Brain Injury

Brain Regions Associated With Internalizing and Externalizing Psychiatric Symptoms in Patients With Penetrating Traumatic Brain Injury

Effects of music and music therapy on mood in neurological patients

The Use of Antidepressant Medication before and after the Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Cohort Study

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