Depression and Mortality in Type 2 Diabetes Mellitus

Lee, Seo Young; Choi, Sung Hee

doi:10.4093/dmj.2017.41.4.263

“…Towler et al found that these hormones may cause changes in anxiety, irritability, and hunger. This statement is supported by Lee and Choi (2017); the pathologies occur due to hypothalamicpituitary-adrenal axis (HPA), which controls the secretion of cortisol and causes changes to the neurological system. The hippocampus, having an anatomical link with the HPA axis, plays a vital function in controlling human's emotion and memory.…”

Section: Dietary Patterns Causing Anxietymentioning

confidence: 99%

“…According to Sarris et al, nutrients which include tryptophan, vitamin B6, vitamin B12, folic acid, phenylalanine, tyrosine, histidine, choline, and glutamic acid are important for the development of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are involved in mood, appetite, cognition, behavior (El-Merahbi et al 2015), learning (El-Merahbi et al 2015), and glucose homeostasis (El-Merahbi et al 2015). Lee and Choi (2017) also explained how the hypothalamic-pituitary-adrenal axis (HPA) controls the secretion of cortisol and causes changes to the neurological system. It plays an important role in regulating human's emotion and memory since the hippocampus that regulates these functions in the human brain is connected anatomically with the HPA axis.…”

Section: Food and Brain Functionsmentioning

confidence: 99%

Nutrition and Anxiety Disorders

Musa

¹

2022

Nutritional Neurosciences

0

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This book series aims to publish volumes focusing on both basic and clinical research in the field of nutritional neuroscience with a focus on delineating the effect of nutrition on brain function and behavior. The books will examine the role of different nutrients, food agents and supplements (both macro and micro) on brain health, neurodevelopment, neurochemistry, and behaviour. The books will examine the influence of diet, including phytochemicals, antioxidants, dietary supplements, food additives, and other nutrients on the physiology and metabolism of neurons, neurotransmitters and their receptors, cognition, behavior, and hormonal regulations.The books will also cover the influence of nutrients and dietary supplements on the management of neurological disorders. It details the mechanism of action of phytonutrients on signaling pathways linked with protein folding, aggregation, and neuroinflammation. The books published in the series will be useful for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.

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“…Towler et al found that these hormones may cause changes in anxiety, irritability, and hunger. This statement is supported by Lee and Choi (2017); the pathologies occur due to hypothalamicpituitary-adrenal axis (HPA), which controls the secretion of cortisol and causes changes to the neurological system. The hippocampus, having an anatomical link with the HPA axis, plays a vital function in controlling human's emotion and memory.…”

Section: Dietary Patterns Causing Anxietymentioning

confidence: 99%

“…According to Sarris et al, nutrients which include tryptophan, vitamin B6, vitamin B12, folic acid, phenylalanine, tyrosine, histidine, choline, and glutamic acid are important for the development of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are involved in mood, appetite, cognition, behavior (El-Merahbi et al 2015), learning (El-Merahbi et al 2015), and glucose homeostasis (El-Merahbi et al 2015). Lee and Choi (2017) also explained how the hypothalamic-pituitary-adrenal axis (HPA) controls the secretion of cortisol and causes changes to the neurological system. It plays an important role in regulating human's emotion and memory since the hippocampus that regulates these functions in the human brain is connected anatomically with the HPA axis.…”

Section: Food and Brain Functionsmentioning

confidence: 99%

Nutrition and Psychiatric Disorders

2022

Nutritional Neurosciences

1

0

View full text Add to dashboard Cite

This book series aims to publish volumes focusing on both basic and clinical research in the field of nutritional neuroscience with a focus on delineating the effect of nutrition on brain function and behavior. The books will examine the role of different nutrients, food agents and supplements (both macro and micro) on brain health, neurodevelopment, neurochemistry, and behaviour. The books will examine the influence of diet, including phytochemicals, antioxidants, dietary supplements, food additives, and other nutrients on the physiology and metabolism of neurons, neurotransmitters and their receptors, cognition, behavior, and hormonal regulations.The books will also cover the influence of nutrients and dietary supplements on the management of neurological disorders. It details the mechanism of action of phytonutrients on signaling pathways linked with protein folding, aggregation, and neuroinflammation. The books published in the series will be useful for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.

show abstract

“…Depression increases the development of T2DM and the subsequent risk of complications such as hyperglycemia, insulin resistance, microvascular and macrovascular; in contrast, T2DM also increases the risk of depression in the patient and may lead to more severe depression 3,4 . This association reflects a common etiology consisting of complex bidirectional interactions between multiple variables, including autonomic disorders, neurohormonal disorders, weight gain, inflammation, and hippocampal structural changes 5 .…”

Section: Introductionmentioning

confidence: 95%

Relationships of Non-coding RNA with diabetes and depression

An

¹

,

Zhang

²

,

Ma

³

et al. 2019

Sci Rep

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In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9), blood glucose and HbA1c, we divided the patients into T2DM and DD group. Peripheral blood was collected from the two groups of patients to perform lncRNA, mRNA, and circRNA expression profiling and screening DD-related specific molecules. Subsequently, bioinformatics analysis was performed to investigate the functions of differentially expressed genes (DEgenes). Finally, RT-PCR and lncRNA-mRNA regulatory network was performed to verify the expressions of lncRNAs and mRNAs related to the occurrence and development of DD. 28 lncRNAs, 107 circRNAs, and 89 mRNAs were identified in DD differential expression profiles. GO and pathway analysis found that 20 biological process (BP) related entities and 20 pathways associated with DD. The analysis shows that the genes that are differentially expressed in the DD group involved in the development of the neuropsychiatric system, immunity, and inflammation. Then, we screening for the important DElncRNA and mRNA associated with DD were verified by RT-PCR experiments and the results of RT-PCR were consistent with the sequencing results. LncRNA, circRNA, and mRNA differential expression profiles exist in DD patients compared with T2DM. The lncRNA-mRNA regulatory network analysis confirmed the crosslinking and complex regulation patterns of lncRNA and mRNA expression and verified the authenticity of the regulatory network.

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Depression and Mortality in Type 2 Diabetes Mellitus

Cited by 4 publications

References 10 publications

Nutrition and Anxiety Disorders

Nutrition and Anxiety Disorders

Nutrition and Psychiatric Disorders

Relationships of Non-coding RNA with diabetes and depression

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