Depression and monoamine oxidase

Coper, H.; Fähndrich, E; Gebert, Alfred; Helmchen, Hanfried; Honecker, Henning; Müller‐Oerlinghausen, B.; Pietzcker, A.

doi:10.1016/0364-7722(79)90000-6

Cited by 20 publications

(13 citation statements)

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“…The present findings on MAO agree with reports by some authors [2, 20, 24] but not with others [13,17,19]. The reason for divergent findings on platelet MAO in patients with bipolar depression [7] has been analyzed in detail previously. This problem will probably be solved only when the same methodology is used by all researchers.…”

Section: Methodssupporting

confidence: 75%

“…The measure of platelet MAO activity used in the present study was the maximum reaction velocity (V) towards tyramine [7].…”

Section: Methodsmentioning

confidence: 99%

“…Assessment of the activity of MAO, COMT, and serum DBH was performed as described previously [5,7,11,14]. The measure of platelet MAO activity used in the present study was the maximum reaction velocity (V) towards tyramine [7].…”

Section: Methodsmentioning

confidence: 99%

“…Cross-sectional designs have shortcomings, however, such as the influence of chance on the inter pretation of results and the failure to detect state variables [7,9,11]. Like wise, longitudinal experiments alone have shortcomings such as the failure to indicate trait variables.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

Fähndrich¹,

Müller‐Oerlinghausen²,

Coper³

1982

Int Pharmacopsychiatry

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This study was carried out to determine whether the activity of regulatory enzymes for biogenic amines are state variables or trait variables for bipolar depression. The activity of MAO, COMT, and DBH in platelets, RBC and serum, respectively, was measured repeatedly in patients with bipolar depression and in matched control subjects. An increase in MAO activity was observed in patients compared to controls, while MAO activity was unrelated to the patient’s psychopathological state. COMT activity was higher in female patients than in female controls and was lower in male patients than in male controls, but it failed to be related to the psychopathological state of patients. Relevant differences in serum DBH activity failed to occur either between patients and controls, or in patients during different states of their illness. The findings suggest that the activity of MAO and COMT are trait variables for bipolar depression, while DBH activity is neither a state variable nor a trait variable. It is discussed why only longitudinal studies in contrast to conventional cross-sectional assessments allow a distinction between state and trait variables.

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Section: Methodssupporting

confidence: 75%

“…The measure of platelet MAO activity used in the present study was the maximum reaction velocity (V) towards tyramine [7].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

Fähndrich¹,

Müller‐Oerlinghausen²,

Coper³

1982

Int Pharmacopsychiatry

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“…Similar correlations between mood and MAO activity were determined for both substrates. Though the association between platelet MAO activity and depressive illnesses is controversial (Coper, Fahndrich, Gebert, Helmchen, Honesker, Muller-Oertinghansen & Pietzker, 1979), these results suggest that platelet MAO activity may be a suitable marker for neurotic depressive symptoms at least in post natal mental disorders.…”

mentioning

confidence: 94%

Proceeding of the British Pharmacological Society, Clinical Pharmacology Section, 16‐18th December, 1980, University of London. Abstracts.

Calvey¹,

Chan²,

Dehghan³

et al. 1981

Brit J Clinical Pharma

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The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors

et al. 2009

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Epigenetics is defined as heritable changes to the transcriptome that are independent of changes in the genome. The biochemical modifications that govern epigenetics are DNA methylation and posttranslational histone modifications. Among the histone modifications, acetylation and deacetylation are well characterized, whereas the fields of histone methylation and especially demethylation are still in their infancy. This is particularly true with regard to drug discovery. There is strong evidence that these modifications play an important role in the maintenance of transcription as well as in the development of certain diseases. This article gives an overview of the mechanisms of action of histone methyltransferases and demethylases, their role in the formation of certain diseases, and available inhibitors. Special emphasis is placed on the strategies that led to the first inhibitors which are currently available and the screening approaches that were used in that process.

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Depression and monoamine oxidase

Cited by 20 publications

References 0 publications

Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

Proceeding of the British Pharmacological Society, Clinical Pharmacology Section, 16‐18th December, 1980, University of London. Abstracts.

The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors

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