Depression and Health Self-perception: Associations Within the Isolated Mennonite Population in South Brazil

Boldt, Michele Christie; Oliveira, Luana Caroline; Kretzschmar, Gabriela Canalli; Meissner, Caroline Grisbach; Mallmann, Mariana Bonotto; Silveira, Jocelaine Martins da; Lopes, Fabiana L.; Boldt, Angelica Beate Winter

doi:10.1007/s10903-020-01046-x

Cited by 1 publication

(5 citation statements)

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“…The Mennonite population is relatively isolated, making it challenging to approach a large number of participants. Boldt et al 2 conducted a study involving 430 Mennonites and found worse self-rated health and higher depression and anxiety scores on the Beck Depression Inventory and Beck Anxiety Inventory. These were different scales, and there was extensive participation from the Mennonite population of Colônia Nova, who scored higher on the scales and were not included in the headache survey.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The present study was carried out within the genetic-epidemiological Mennogen project with the South-Brazilian Mennonite population. 2 In order to retrospectively and cross-sectionally evaluate the characteristics of headaches in this population, we publicized and explained the research goals in social and religious events. Individuals interested in participating in the survey received access to the questionnaires through a Google Forms platform link.…”

Section: Methodsmentioning

confidence: 99%

“…These were different scales, and there was extensive participation from the Mennonite population of Colônia Nova, who scored higher on the scales and were not included in the headache survey. 2 A selection method other than spontaneous participation, also including rural communities, is required to obtain more reliable results regarding prevalence. Gathering information about the familial pattern of MO and MA associated with genome sequencing would shed more light on the role of genetic variants in this population.…”

Section: Figure 1 Frequency Polygon Of the Duration Of The Headache A...mentioning

confidence: 99%

“…1 Genetic drift, reproductive isolation, and at least three bottleneck effects in this population are expected to increase the frequencies of homozygotes and rare alleles, changing the prevalence of chronic diseases. [1][2][3][4] An example of this would be the higher prevalence of dystonia in the Amish, also an Anabaptist population. 5 There are several different subgroups of Mennonites.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of headaches in an urban Mennonite group in South Brazil

Dück,

Utiumi,

Boldt

et al. 2023

Arq Neuropsiquiatr

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Background Genetic variants play a pathophysiological role in headaches, especially in migraine. The Mennonite group (MG) has been geographically and genetically isolated throughout its history, harboring a distinctive distribution of diseases. Objective To determine the characteristics of headaches in a group with direct Mennonite ancestry contrasting with other urban community members (control group [CG]). Methods Subjects with headaches were asked to complete a questionnaire covering: the type of headache, presence of aura, frequency and duration of attacks, pain location and severity, analgesic consumption, premonitory and postdromic manifestations, Depressive Thoughts Scale, Epworth Sleepiness Scale (ESS), General Anxiety Disorder-7, Patient Health Questionnaire-9 (PHQ-9), Migraine Disability Assessment, and Composite Autonomic System Score. Results We included 103 participants (CG: 45, Mennonite group [MG]: 58). Migraine was the most common headache (CG: 91.1%; MG: 81.0%; p = 0.172), followed by tension-type headache (CG: 8.9%; MG: 15.5%; p = 0.381). Aura was identified by 44.4% and 39.7% in the CG and MG, respectively (p = 0.689). The groups differed only concerning the frequency of retro-orbital pain (CG: 55.6%; MG: 32.8%; p = 0.027), PHQ-9 (CG: median 7, range 0 to 22; MG: median 5, range 0 to 19; p = 0.031) and ESS (CG: median 0, range 0 to 270; MG: median 0, range 0 to 108; p = 0.048) scores. Conclusion There were no major differences in the prevalence and clinical characterization of headaches between the MG and the CG. However, the latter showed more diffuse pain, sleepiness, and depressive symptoms. Specific genetic or epigenetic variants in Mennonite descendants might account for these differences.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Figure 1 Frequency Polygon Of the Duration Of The Headache A...mentioning

confidence: 99%