Irritable bow el syndrome (IBS) is a common yet poorly understood functional bow el disorder.A multi-factorial aetiology has been proposed, and abnorm alities in colonic motility, small bow el motility and visceral sensation have been observed experimentally. M ore recently, attention has turned to a quite distinct abnorm ality, nam ely psychological function. Studies have shown that for a signi® cant proportion of the IBS popula tion, co-morbid psychiatric disturbance may be aetiopathological, w ith the physical abnorm alities described occurring in response to stress or anxiety induc ed experimentally. Others have suggested that psychological distress may occur as a result of severe gastrointestinal symptoms, and that psychosocial factors may be related to the presentation rather than genesis of the symptom s. M any of these studies contain methodological inadequacies w hich may adversely affect the results obtained. Com parison between studies, w hich may provide further insight, is often dif® cult due to inconsistencies in the experimental protocol and the non-standard w ays in which data have been presented. It is likely, how ever, that differences betw een methodologies may, in part, explain the variations in results betw een studies.