Depression and dementia: the multi-faceted relationship

Mahendra, B.

doi:10.1017/s0033291700023503

Cited by 78 publications

(40 citation statements)

References 36 publications

(44 reference statements)

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“…A lack of association between dementia and depression in community studies has been noted by others (Lindesay et al, 1989;O'Connor et al, 1990). However, depression was most common in mild dementia, which is in line with other studies (Gustafson and Hagberg, 1975;Wragg and Jeste, 1989;Burns and Levy, 1990;Fischer et al, 1990;Mahendra, 1985;Reifler et al, 1986;Cooper et al, 1990;Merriam et al, 1988). The lower rate in severe dementia may be the result of the cholinergic deficiency, which may have a protective effect against depression (Cummings et al, 1987;Cummings, 1989;Fischer et al, 1990;Mahendra,1985).…”

Section: Resultssupporting

confidence: 79%

“…The co-occurrence of depression and dementia has received much attention (Mahendra, 1985;Cummings, 1989;Reifler et al, 1986). The prevalence of depression in demented subjects in the present study (25%) was fairly similar to the 10-20% found in patient samples (Wragg and Jeste, 1989;Burns and Levy, 1990;Reifler et aL, 1986;Rosen and Zubenko, 1991;Cummings, 1989;Greenwald et al, 1989;Rovner et al, 1989), but not significantly different from the rate in non-demented subjects (20%).…”

Section: Resultsmentioning

confidence: 99%

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The prevalence of psychotic, depressive and anxiety syndromes in demented and non‐demented 85‐year‐olds

Skoog

1993

Int J Geriat Psychiatry

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SUMMARYOne-month prevalence of mental syndromes in demented and non-demented subjects was studied in a representative sample of 85-year-olds living in Gothenburg, Sweden (N = 494). Ail subjects were examined by a psychiatrist. Schizophreniform syndrome was significantly more common in subjects with Alzheimer's disease than in nondemented subjects (13% vs 1'30, p < 0.001), and more common in severe dementia (p < 0.01). Depressive syndromes were significantly more common in subjects with mild dementia than in non-demented subjects (34% vs 20%, p < 0.05). Phobic syndrome was less common in demented than in non-demented subjects. It is hypothesized that the occurrence of mental syndromes in demented subjects may be related to structural and neurochemical brain changes.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

The prevalence of psychotic, depressive and anxiety syndromes in demented and non‐demented 85‐year‐olds

Skoog

1993

Int J Geriat Psychiatry

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“…Other studies corroborate the co-occurrences of affective and cognitive disorders but differ in the consideration of actual incidences [4][5][6][7][8][9][10]. In some cases, severe chronic depression precedes the onset of SDAT by a number of years causing speculation that, at least in some propor tion of these cases, the biological mechanisms underlying one disease may coexist with or overlap those of the sec ond.…”

Section: Introductionmentioning

confidence: 99%

Depression and Senile Dementia of the Alzheimer Type: Catecholamine Changes in the Locus coeruleus – Basis for Therapy

Chan-Palay¹

1990

Dement Geriatr Cogn Disord

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This paper describes the clinical, psychometric, neuropathological, and neurotransmitter studies on 8 patients selected from the ZÜrich study on dementia. It confirms the age-related loss of norepinephrine neurons in the locus coeruleus (LC) in control patients without neurological or psychiatric disease. A relationship between the incremental loss of LC neurons in patients with senile dementia (SDAT) and presenile dementia of the Alzheimer type and the increasing severity of the clinical disease was found. The morphological characteristics of altered Alzheimer neurons with enlarged somata and distorted shortened processes are described. The norepinephrine neurons in the LC of the 3 cases with depressive disorders, depression, Parkinson's disease with depression, and SDAT with depression, had in common severe LC norepinephrine cell losses and low levels of catecholamine-synthesizing enzyme signifying reduced norepinephrine levels. The significance of these findings in relation to the possible treatments of depression in complex coexistent diseases such as depression and SDAT are discussed.

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“…Smith and Kiloh, 1981;Reifler et al, 1982;Mahendra, 1985;Lazarus et al, 1987;Burke et al, 1988;Wragg and Jeste, 1989]. In this paper, I shall ask why such an observation should attract interest; why epidemiological data may extend our un derstanding beyond what can be gained from clinical studies; and what methodological issues have to be con fronted in this field, if it is to be further explored.…”

mentioning

confidence: 97%

Co-Occurrence of Affective and Cognitive Symptoms: The Epidemiological Evidence

Henderson¹

1990

Dement Geriatr Cogn Disord

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Affective and cognitive symptoms co-occur considerably above chance in clinical (i.e. treated) samples. By contrast, in population-based surveys, the syndromes of depression and dementia do not occur at the case level more than by chance, but symptoms of each may correlate significantly though never strongly. Epidemiological data from prospective longitudinal studies are now sought, focussed on cases showing both groups of symptoms.

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Depression and dementia: the multi-faceted relationship

Cited by 78 publications

References 36 publications

The prevalence of psychotic, depressive and anxiety syndromes in demented and non‐demented 85‐year‐olds

The prevalence of psychotic, depressive and anxiety syndromes in demented and non‐demented 85‐year‐olds

Depression and Senile Dementia of the Alzheimer Type: Catecholamine Changes in the Locus coeruleus – Basis for Therapy

Co-Occurrence of Affective and Cognitive Symptoms: The Epidemiological Evidence

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