Depression and chronic diseases: Co-occurrence and communality of risk factors

Lotfaliany, Mojtaba; Bowe, Steven J.; Kowal, Paul; Orellana, Liliana; Berk, Michael; Mohebbi, Mohammadreza

doi:10.1016/j.jad.2018.08.011

Cited by 111 publications

(76 citation statements)

References 25 publications

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“…Depression has been further identified as independent risk factor and negative prognostic factor for many chronic somatic disorders, including diabetes, cardiovascular disease, hypertension, chronic respiratory disorders, and arthritis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Comorbid depression in physical disease is related to poor quality of life, worse course of the physical disorder, higher functional impairment and disability, increased service utilization and higher medical costs, and increased mortality compared to the presence of either depression or the physical disease alone [18,20,24,25,[27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data

et al. 2020

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Background: Depression is frequently accompanied by other mental disorders and various somatic diseases; however, previous comorbidity studies often relied on self-reported data and have not simultaneously assessed the entire spectrum of mental and somatic diagnoses. The aim is to provide a complete picture of mental and somatic comorbidity of depression in routine outpatient care in a high income country with a relatively well equipped health care system. Methods: Using ambulatory claims data covering 87% of the German population (age 15+), we designed a cross-sectional study by identifying persons diagnosed with mild, moderate and severe depression in 2017 (N = 6.3 million) and a control group matched 4:1 on sex, 5-year age group and region of residence (N = 25.2 million). Stratified by severity, we calculated the prevalence of 202 diagnosis groups included in the ICD-10 in persons with depression as compared to matched controls using prevalence ratios (PR). Results: Nearly all mental disorders were at least twice as prevalent in persons with depression relative to controls, showing a dose-response relationship with depression severity. Irrespective of severity, the three most prevalent somatic comorbid diagnosis groups were 'other dorsopathies' (M50-M54), 'hypertensive diseases' (I10-I15) and 'metabolic disorders' (E70-E90), exhibiting PRs in moderate depression of 1.56, 1.23 and 1.33, respectively. Strong associations were revealed with diseases of the central nervous system (i.e. multiple sclerosis) and several neurological diseases, among them sleep disorders, migraine and epilepsy, most of them exhibiting at least 2-to 3-fold higher prevalences in depression relative to controls. Utilization of health care was higher among depression cases compared to controls.

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Section: Introductionmentioning

confidence: 99%

Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data

et al. 2020

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“…Additionally, a Canadian longitudinal study reported that the prevalence of depressive episode at baseline was 7.5% 4. Based on World Mental Health Survey data, a cross-sectional study identified diabetes, arthritis, asthma, chronic pulmonary disease, angina symptoms, stroke, advanced age, women, underweight and lower levels of income and education as risk factors related to depressive symptoms 5…”

Section: Introductionmentioning

confidence: 99%

Association between severity of depressive symptoms and chronic knee pain in Korean adults aged over 50 years: a cross-sectional study using nationally representative data

Han

Lee

et al. 2019

BMJ Open

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ObjectivesTo identify the association between the presence and severity of depressive symptoms and those of chronic knee pain.DesignA retrospective cross-sectional study.ParticipantsWe used data from the sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-2) performed in 2014. Overall, 7550 patients were included in the KNHANES VI-2.Outcome measuresParticipants were asked whether they had chronic knee pain, and each answer was either ‘yes’ or ‘no’. Patient Health Questionnaire-9 (PHQ-9) was used as a screening tool for depressive symptoms, and PHQ-9 scores of 10 or higher was classified as the depressed group. In total, 527 patients reported that they had pain in their knee, of whom 91 also had depressive symptoms.ResultsThe prevalence of chronic knee pain in the Korean population aged over 50 years was 19.8%. Multiple logistic regression was conducted after adjustment for sex, age, smoking, alcohol drinking, education level, household income, physical activity, sleep duration and comorbidity. The analysis revealed a significant association between depressive symptoms and chronic knee pain (adjusted OR=2.333, p<0.001). In contrast, the severity of depressive symptoms was linearly correlated with the intensity of chronic knee pain (p for trend <0.001). In participants with no chronic knee pain (Numerical Rating Scale; NRS=0) or mild chronic knee pain (NRS=1–4), the prevalence of moderate and severe depressive symptoms was 3.4% and 0.6%, respectively. However, in those with severe chronic knee pain (NRS=8–10), there was a higher prevalence of moderate and severe depressive symptoms (10.1% and 5.8%, respectively) (p<0.001).ConclusionsA strong association was observed between the presence and severity of depressive symptoms and the presence of chronic knee pain. The association became stronger with higher levels of depressive symptoms, indicating a positive correlation between depressive symptoms severity and chronic knee pain.

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“…Additionally, patients with one chronic disease had increases 58% the risk of depression, while the risk was higher for patients with at least two chronic diseases. 19 Interestingly, the instrument used in this study can also affect the prevalence of depression. The Zung Self-Rating Depression Scale (SDS) has a high sensitivity, but the use of this questionnaire mostly errors in setting the appropriate cut-off.…”

Section: Discussionmentioning

confidence: 96%

Depression and Sleep Quality in Outpatients attending Penjaringan Primary Health Care, North Jakarta: A Cross-sectional Study

et al. 2020

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Introduction: Depression is the most common mental disorder. Depression of outpatients in primary health care is frequently unrecognized. It might affect sleep quality, which is associated with worse quality of life, poor medication adherence, higher morbidity, and mortality. The study aimed to determine the association between depression and sleep quality of outpatients in Penjaringan Primary Health Care, Jakarta. Method: This research was observational analytic using a cross-sectional approach involving 434 outpatients in Penjaringan Primary Health Care, Jakarta. The study was conducted from August until September 2019. Instruments used in this research were the demographic questionnaire, the Zung Self-Rating Depression (SDS) questionnaire, and the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data analytics were bivariate. Results: There were 19.1% of respondents had depression, including 12.2% mild depression, 5.8% moderate depression, and 1.2% severe depression. There were 53.5% of respondents had poor sleep quality. There was a significant relationship (p<0.001, OR=7.814) between depression and sleep quality in outpatients. The results also showed that depression scores were moderately correlated with sleep disturbances (r=0.434). Conclusion: This study showed a high prevalence of depression and poor sleep quality among outpatients. Depression was associated with a 7.8 times higher risk of having poor sleep quality and also correlated with the components of sleep quality especially sleep disturbance.

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Depression and chronic diseases: Co-occurrence and communality of risk factors

Cited by 111 publications

References 25 publications

Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data

Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data

Association between severity of depressive symptoms and chronic knee pain in Korean adults aged over 50 years: a cross-sectional study using nationally representative data

Depression and Sleep Quality in Outpatients attending Penjaringan Primary Health Care, North Jakarta: A Cross-sectional Study

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