Depression and cardiovascular disease: a reciprocal relationship

Plante, Gérard E.

doi:10.1016/j.metabol.2005.01.013

Cited by 65 publications

(52 citation statements)

References 43 publications

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“…110 A recent study showed that the ss genotype of SERT is linked to major depressive disorder. 111 Depression is also a risk factor for hypertension 112 and myocardial infarction (MI). 113,114 Similarly, clinical studies have demonstrated that hypertensive patients and MI patients are more likely to be depressed.…”

Section: Serotonin Transporter Depression and CV Diseasementioning

confidence: 99%

“…113,114 Similarly, clinical studies have demonstrated that hypertensive patients and MI patients are more likely to be depressed. 112,114 It is unknown whether patients with CV disease are derived from populations with a particular genotype for expression of SERT, such as the ss genotype in the depressed patient. Further complications include whether hypertension and depression are causal in the genesis of the other malady.…”

Section: Serotonin Transporter Depression and CV Diseasementioning

confidence: 99%

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5‐hydroxytryptamine in the Cardiovascular System: Focus on the Serotonin Transporter (Sert)

Watts

2006

Clin Exp Pharma Physio

154

102

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SUMMARY1. The function of the serotonin transporter (SERT) is to take up and release serotonin (5-hydroxytyptamine (5-HT)) from cells and this function of SERT in the central nervous system (CNS) is well-documented; SERT is the target of selective serotonin reuptake inhibitors used in the treatment of CNS disorders, such as depression.2. The aim of the present review is to discuss our current knowledge of 5-HT and SERT in the cardiovascular (CV) system, as well as their function in physiological and pathophysiological states.3. The SERT protein has been located in multiple CV tissues, including the heart, blood vessels, brain, platelets, adrenal gland and kidney. Modification of SERT function occurs at both transcriptional and translational levels. The functions of SERT in these tissues is largely unexplored, but includes modulation of cardiac and smooth muscle contractility, platelet aggregation, cellular mitogenesis, modulating neuronal activity and urinary excretion.4. Recent studies have uncovered potential relationships between the expression of SERT gene promoter variants (long (l) or short (s)) with CV diseases. Specifically, the risk of myocardial infarction and pulmonary hypertension is increased with expression of the ll promoter, a variant associated with increased expression and function of SERT. The relationship between promoter variants and other CV diseases has not been investigated.5. Newly available experimental tools, such as pharmacological compounds and genetically altered mice, should prove useful in the investigation of the function of SERT in the CV system. 6. In summary, the function of SERT in the CV system is just beginning to be revealed.

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Section: Serotonin Transporter Depression and CV Diseasementioning

confidence: 99%

Section: Serotonin Transporter Depression and CV Diseasementioning

confidence: 99%

5‐hydroxytryptamine in the Cardiovascular System: Focus on the Serotonin Transporter (Sert)

Watts

2006

Clin Exp Pharma Physio

154

102

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“…Depressed smokers are also less likely to quit smoking when compared to non-depressed smokers [26] . Importantly, major depression is associated with CVD, especially during hospitalization after a myocardial infarction [24,25,27] . In addition, the joint presence of major depression and tobacco use increases the morbidity and mortality in persons with CVD [24,25] .…”

Section: Introductionmentioning

confidence: 99%

“…Smoking and depression are risk factors of CVD, particularly among hospitalized patients, and the presence of both increases morbidity and mortality rates in patients with CVD [24,25,27] .…”

Section: Introductionmentioning

confidence: 99%

Cigarette and water pipe smoking patterns among hospitalized men with a cardiovascular disease diagnosis

Elshatarat

Engler

Stotts

et al. 2014

JNEP

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Background: Smoking is the most preventable cause of death worldwide. Despite the high prevalence of smoking and cardiovascular disease (CVD) in Jordan, little is known about smoking in hospitalized patients with CVD. Objectives:To describe the perceptions, history, and patterns about cigarette and water pipe smoking in hospitalized patients with CVD in Jordan.Methods: Across-sectional design and convenience sampling method were used to recruit a total of 112 men who were hospitalized with CVD. A structured interview was used to obtain the data. Results:The subjects were men, and the majorities were middle-aged, married, highly educated, and employed. About 12% of the subject had major depression. Most of the men (91%) were daily cigarette smokers. The majority of subjects reported that smoking was allowed inside their home (89.3%) and in the presence of children (64%). About 43% of subjects smoked >20 cigarettes per day and 63% of subjects smoked their first cigarette within 30 minutes after waking. Most of the water pipe smokers (66.7%) preferred to smoke their water pipe while socializing with friends. More cigarette smokers (77%) than water pipe smokers (40%) believed that smoking is addictive. A logistic regression analysis showed that men with less than high school education (OR: 4.18, 95% CI: 1.16, 15.13), and who smoked more than 20 cigarettes per day (OR: 7.34, 95% CI: 2.53, 21.33) were inclined to smoke their first cigarette within 30 minutes after awakening in the morning (high nicotine dependence); suggesting that they were addicted. Conclusion:Smoking is highly prevalent among hospitalized patients with CVD. Strategies are needed to screen these patients for smoking status. Concerted efforts are needed to implement tailored smoking cessation programs with education, counseling, and pharmacological support.

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“…При депре-сії відбувається порушення серотонінергічних і адренергічних шляхів передачі сигналів, накопи-чення метаболітів (таких як гомоцистеїн, фактор активації тромбоцитів і ряду інших) [9,6]. Серото-нін має різні серцево-судинні ефекти, включаючи індукцію аритмії і вазоконстрикцію.…”

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Оцінка Депресивних Розладів У Хворих З Анкілозивним Спондилоартритом

Koshak¹

2016

ЗКЕМ

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РЕЗЮМЕ. Для визначення глибини депресивних змін обстежено 70 хворих на анкілозивний спондилоартрит (АТ) з використанням тесту Бека та шкали Тейлора. Встановлено, що найвищий рівень депресивних розладів зустрічається за умов вперше встановленого діагнозу анкілозивного спондилоартриту. Надалі при адекватному лікуванні вдається домогтися значного покращення психоемоційного стану на 1-10 році захворювання. Проте при поступовому прогресуванні захворювання за умов незворотних змін якість життя значно погіршується, що проявляється значним погіршанням в психоемоційній сфері і потребує медикаментозної корекції.КЛЮЧОВІ СЛОВА: анкілозивний спондилоартрит, депресія.

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Depression and cardiovascular disease: a reciprocal relationship

Cited by 65 publications

References 43 publications

5‐hydroxytryptamine in the Cardiovascular System: Focus on the Serotonin Transporter (Sert)

5‐hydroxytryptamine in the Cardiovascular System: Focus on the Serotonin Transporter (Sert)

Cigarette and water pipe smoking patterns among hospitalized men with a cardiovascular disease diagnosis

Оцінка Депресивних Розладів У Хворих З Анкілозивним Спондилоартритом

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