Depression and cardiovascular autonomic control: a matter of vagus and sex paradox

Tobaldini, Eleonora; Carandina, Angelica; Toschi‐Dias, Edgar; Erba, Luca; Furlan, Ludovico; Sgoifo, Andrea; Montano, Nicola

doi:10.1016/j.neubiorev.2020.06.029

Cited by 28 publications

(19 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, from a physiological point of view, HRV is also postulated to mediate the negative relationship between self-esteem and work-related exhaustion: high self-esteem, by increasing cardiac vagal tone at work, may lead to reduced exhaustion symptoms. In light of the well-documented sex differences in both the neural control of HRV, with higher HRV in women compared with man (e.g., Koenig and Thayer, 2016;Tobaldini et al, 2020) and in self-esteem (Kling et al, 1999;Zuckerman et al, 2016), we also aimed at exploring the interactive effect of sex and self-esteem on HRV at work. To our knowledge, only one previous study examined the role of sex in the association between self-esteem and HRV.…”

Section: Introductionmentioning

confidence: 99%

Personal Resources and Organizational Outcomes: Sex as a Moderator of the Complex Relationships Between Self-Esteem, Heart Rate Variability, and Work-Related Exhaustion

2021

View full text Add to dashboard Cite

Global self-esteem represents a protective personal resource lowering the risk of psychological distress. Research conducted in the work setting has confirmed the psychosocial benefits of high self-esteem. However, research linking self-esteem to neurobiological adaptability appears quite scarce. In this study, we propose a theoretical model in which self-esteem predicts work-related exhaustion indirectly, through the mediation of heart rate variability (HRV) and negative affect at work. Moreover, we explore the relationship between self-esteem and HRV. From one side, one would expect a positive link between self-esteem and HRV, signaling higher autonomic adaptability. However, recent studies have shown that in women, such associations become more complex, with even reversed patterns as compared with that in men. Thus, we included sex as a moderator of the relationship between HRV and self-esteem. The model was tested on a sample of 110 individuals working in the relational professions (54% males; Mage = 42.6, SD = 13.73), observed for an entire workday. Results confirmed the protective role of self-esteem against the experience of negative affect and (indirectly) work-related exhaustion. Symptoms of exhaustion at work were also negatively predicted by HRV, and both HRV and negative affect acted as mediators of the relationship between self-esteem and work-related exhaustion. Notably, sex differences emerged in the association between global self-esteem and cardiac vagal tone at work: in women, self-esteem was negatively related to HRV, which in turn led to higher work-related exhaustion, whereas in men, no evidence of this indirect effect appeared. Burnout prevention programs should not ignore important sex differences in how individuals respond to work-related stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Personal Resources and Organizational Outcomes: Sex as a Moderator of the Complex Relationships Between Self-Esteem, Heart Rate Variability, and Work-Related Exhaustion

2021

View full text Add to dashboard Cite

show abstract

“…Other possible mechanisms underlying the sex difference in the comorbidity of depression and CVDs include hormonal dysregulation and pro-inflammatory responses. Specific subtypes of depression, such as postpartum depression and post-menopausal depression, suggests the involvement of hormone fluctuations in depression amongst females [33]. Interestingly, Takotsubo cardiomyopathy, often triggered by emotional or physical stress, is the most common in post-menopausal women (90% of cases) [34].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Takotsubo cardiomyopathy, often triggered by emotional or physical stress, is the most common in post-menopausal women (90% of cases) [34]. At the same time, elevated inflammatory biomarkers, such as interleukin-6 and tumour necrosis factor alpha, are reportedly higher in depressed women relative to depressed men, suggesting a sex-differential inflammatory response to MD [33]. These pro-inflammatory cytokines are linked to incident CVD and poorer cardiovascular outcomes [35, 36].…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Jiang

Singh

Davis

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Epidemiological studies show increased cardiovascular disease (CVD) risks amongst individuals with psychiatric disorders, but to what degree this comorbidity is mediated by genetic and non-genetic (including medications) factors remains unclear. This study examined the genetic contribution to this comorbidity, and the sex-specific causal association between higher genetic risk of three psychiatric disorders [major depression (MD), schizophrenia and bipolar disorder] and three CVDs [coronary artery disease (CAD), heart failure (HF) and atrial fibrillation]. Methods Genetic correlation and polygenic overlap between psychiatric disorders and CVDs were estimated using summary statistics from genome-wide association studies. Association between polygenic scores (PGS) for psychiatric disorders and CVD outcomes was assessed in 345,340 European-ancestry individuals (UK Biobank) using logistic regression. Results Though substantial genetic overlap was identified between psychiatric disorders and CVDs, a significant genetic correlation (rg ranged between 0.11 and 0.25, p < 7.8E-06) was only observed between MD and all three CVDs. A 1-standard-deviation increase in PGSMD was associated with a 1.11- (95% CI: 1.06 - 1.16; p = 4.9E-06) and 1.09-fold (95% CI: 1.04 - 1.14; p = 0.00041) higher risk of incident CAD and HF in females, but only with a 1.04-fold (95% CI: 1.02 - 1.07; p = 0.0019) increased risk of incident CAD in males. The PGSMD was associated with CAD and HF even in the absence of any psychiatric disorder diagnosis. Conclusions Our results suggest that the increased CVD risk in individuals with schizophrenia and bipolar disorder is likely a consequence of non-genetic factors (such as lifetime hardships and medications). Notably, shared genetic risk is an important contributor to CVD comorbidity in individuals with a diagnosis or a higher risk of MD, and more so in females than in males. Keywords Psychiatric disorder, cardiovascular disease comorbidity, depression, polygenic risk score, sex-specific risks

show abstract

“…Several systematic analyzes have shown that psychosocial stress is a critical determinant of cardiovascular disease and mortality [24]. Anxiety and depression are often comorbid [25] and are identified as psychosocial risk factors for cardiovascular disease [26,27]. Psycho-cardiological disease has been defined as a Cardiometabolic and sleep/circadian disorders have intricately interconnected pathologies (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Several systematic analyzes have shown that psychosocial stress is a critical determinant of cardiovascular disease and mortality [24]. Anxiety and depression are often comorbid [25] and are identified as psychosocial risk factors for cardiovascular disease [26,27]. Psycho-cardiological disease has been defined as a multidisciplinary condition that includes psychology, psychiatry, clinical medicine (including the cardiovascular system and neurology), public health, environmental health, and occupational health [28].…”

Section: Introductionmentioning

confidence: 99%

Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders

Campos

Baltatu

Senar³

et al. 2023

IJMS

View full text Add to dashboard Cite

Several psychosocial, sleep/circadian, and cardiometabolic disorders have intricately interconnected pathologies involving melatonin disruption. Therefore, we hypothesize that melatonin could be a therapeutic target for treating potential comorbid diseases associated with this triad of psychosocial-sleep/circadian-cardiometabolic disorders. We investigated melatonin’s target prediction and tractability for this triad of disorders. The melatonin’s target prediction for the proposed psychosocial-sleep/circadian-cardiometabolic disorder triad was investigated using databases from Europe PMC, ChEMBL, Open Targets Genetics, Phenodigm, and PheWAS. The association scores for melatonin receptors MT1 and MT2 with this disorder triad were explored for evidence of target–disease predictions. The potential of melatonin as a tractable target in managing the disorder triad was investigated using supervised machine learning to identify melatonin activities in cardiovascular, neuronal, and metabolic assays at the cell, tissue, and organism levels in a curated ChEMBL database. Target–disease visualization was done by graphs created using “igraph” library-based scripts and displayed using the Gephi ForceAtlas algorithm. The combined Europe PMC (data type: text mining), ChEMBL (data type: drugs), Open Targets Genetics Portal (data type: genetic associations), PhenoDigm (data type: animal models), and PheWAS (data type: genetic associations) databases yielded types and varying levels of evidence for melatonin-disease triad correlations. Of the investigated databases, 235 association scores of melatonin receptors with the targeted diseases were greater than 0.2; to classify the evidence per disease class: 37% listed psychosocial disorders, 9% sleep/circadian disorders, and 54% cardiometabolic disorders. Using supervised machine learning, 546 cardiovascular, neuronal, or metabolic experimental assays with predicted or measured melatonin activity scores were identified in the ChEMBL curated database. Of 248 registered trials, 144 phase I to IV trials for melatonin or agonists have been completed, of which 33.3% were for psychosocial disorders, 59.7% were for sleep/circadian disorders, and 6.9% were for cardiometabolic disorders. Melatonin’s druggability was evidenced by evaluating target prediction and tractability for the triad of psychosocial-sleep/circadian-cardiometabolic disorders. While melatonin research and development in sleep/circadian and psychosocial disorders is more advanced, as evidenced by melatonin association scores, substantial evidence on melatonin discovery in cardiovascular and metabolic disorders supports continued R&D in cardiometabolic disorders, as evidenced by melatonin activity scores. A multiplatform analysis provided an integrative assessment of the target–disease investigations that may justify further translational research.

show abstract

Depression and cardiovascular autonomic control: a matter of vagus and sex paradox

Cited by 28 publications

References 108 publications

Personal Resources and Organizational Outcomes: Sex as a Moderator of the Complex Relationships Between Self-Esteem, Heart Rate Variability, and Work-Related Exhaustion

Personal Resources and Organizational Outcomes: Sex as a Moderator of the Complex Relationships Between Self-Esteem, Heart Rate Variability, and Work-Related Exhaustion

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders

Contact Info

Product

Resources

About