Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders

Bryant, Vaughn; Whitehead, Nicole Ennis; Burrell, Larry E.; Dotson, Vonetta M.; Cook, Robert L.; Malloy, Paul F.; Devlin, Kathryn N.; Cohen, Ronald A.

doi:10.1007/s10461-014-0970-1

Cited by 33 publications

(20 citation statements)

References 49 publications

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“…Noteworthy, apathy is significantly associated with high HIV-1 plasma levels and poor neurocognitive performance in HIV-1-infected individuals (Shapiro et al, 2013). Moreover, depression and apathy are hallmarks of HIV-1 patients with a history of cocaine or alcohol abuse (Bryant et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens

Brailoiu

Deliu

Barr

et al. 2017

Drug and Alcohol Dependence

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BACKGROUND HIV-1 infection and drug abuse are frequently co-morbid and their association greatly increases the severity of HIV-1-induced neuropathology. While nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little is known about how HIV-1 infection affects NAcc. METHODS We used calcium and voltage imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat) on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates intracellular Ca2+ homeostasis of NAcc neurons. RESULTS We provide evidence that Tat triggers a Ca2+ signaling cascade in NAcc medium spiny neurons (MSN) expressing D1-like dopamine receptors leading to neuronal depolarization. Firstly, Tat induced inositol 1,4,5-trisphsophate (IP3) receptor-mediated Ca2+ release from endoplasmic reticulum, followed by Ca2+ and Na+ influx via transient receptor potential canonical channels. The influx of cations depolarizes the membrane promoting additional Ca2+ entry through voltage-gated P/Q-type Ca2+ channels and opening of tetrodotoxin-sensitive Na+ channels. By activating this mechanism, Tat elicits a feed-forward depolarization increasing the excitability of D1-phosphatidylinositol-linked NAcc MSN. We previously found that cocaine targets NAcc neurons directly (independent of the inhibition of dopamine transporter) only when IP3-generating mechanisms are concomitantly initiated. When tested here, cocaine produced a dose-dependent potentiation of the effect of Tat on cytosolic Ca2+. CONCLUSION We describe for the first time a HIV-1 Tat-triggered Ca2+ signaling in MSN of NAcc involving TRPC and depolarization and a potentiation of the effect of Tat by cocaine, which may be relevant for the reward axis in cocaine-abusing HIV-1-positive patients.

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Section: Discussionmentioning

confidence: 99%

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens

Brailoiu

Deliu

Barr

et al. 2017

Drug and Alcohol Dependence

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“…Some studies have described the specific comorbid effects of depression within chronic disease populations. For example, studies have shown that depression is associated with cognitive decline, faster disease progression, and increased mortality in persons living with HIV (Bryant et al, 2015; Rivera-Rivera et al, 2016). Among persons living with cancer, depression often worsens other cancer symptoms and results in more symptom interference, poor adherence, and worse outcomes and survival (Kim et al, 2015; Stanton et al, 2018; Zimmaro et al, 2018).…”

Section: Increased Depressive Symptoms In Persons With Comorbid Condimentioning

confidence: 99%

Depression as a Comorbid Condition: A Descriptive Comparative Study

Frain

Chen

2020

West J Nurs Res

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Studies analyzing depressive symptoms across chronic disease populations are limited. Our descriptive comparison investigation included two studies on life-limiting conditions: Human Immunodeficiency Virus (HIV) and breast cancer. In both, depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CES-D). We found a mean depression score of 18.1 (± 11.8) overall ( N = 243). Over half (54%) reported clinically significant depressive symptoms (CES-D ≥ 16); 26% reported severe depressive symptoms (CES-D > 24). Disease and years of education were predictors of depressive symptoms. Persons living with breast cancer showed significantly worse depressive symptoms than persons living with HIV (p < 0.0001). After adjusting for disease, fewer years of education predicted worse depressive symptoms (p < 0.0001). This study demonstrated common determinants of depressive symptoms in both disease populations, suggesting that underlying conditions known to be predictors of depression could be assessed to identify those at higher risk for depression.

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“…Multiple studies have indicated that adults with HIV and depression as well as post-traumatic stress disorder were more likely to experience cognitive impairments (Bryant et al, 2015; Rubin et al, 2016). Fortunately, studies have also suggested that if emotional health is restored through pharmacological or non-pharmacological treatments, cognitive function rebounds (Bryant et al, 2015).…”

Section: Lifestyle Factors Brain Health and Cognitionmentioning

confidence: 99%

“…Fortunately, studies have also suggested that if emotional health is restored through pharmacological or non-pharmacological treatments, cognitive function rebounds (Bryant et al, 2015). This highlights the need to address emotional health in this clinical population.…”

Section: Lifestyle Factors Brain Health and Cognitionmentioning

confidence: 99%

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

Vance¹,

Gakumo²,

Childs³

et al. 2017

Journal of the Association of Nurses in AIDS Care

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As people age with HIV, cognitive problems may become more prevalent and severe, but lifestyle behaviors (i.e., physical activity) have been shown to protect brain health and cognition. We examined the perceptions that older adults living with HIV have about protecting and improving brain health and cognition through lifestyle behaviors. Qualitative data were analyzed from 4 focus groups (N = 30) of African Americans and Caucasians living with HIV and at least 50 years of age. An open-coding scheme using conventional content analysis was employed. Two results were found. First, many older adults with HIV in our study expressed a variety of cognitive complaints that interfered with daily function. Second, these participants reported few specific ideas about how such health behaviors were important to their own brain health and cognition. Education interventions may help older adults with HIV learn to improve and protect brain health and cognition as they age.

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Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders

Cited by 33 publications

References 49 publications

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens

Depression as a Comorbid Condition: A Descriptive Comparative Study

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

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