Depression and anxiety related subtypes in Parkinson's disease

Brown, Richard G.; Landau, Sabine; Hindle, John V.; Playfer, Jeremy; Samuel, Michael; Wilson, Kevin C.; Hurt, Catherine S.; Anderson, Rachel J.; Carnell, Joanna; Dickinson, Lucy; Gibson, Grant; Schaick, Rachel van; Sellwood, Katie; Thomas, Bonnita A.; Burn, David J.

doi:10.1136/jnnp.2010.213652

Cited by 160 publications

(157 citation statements)

References 42 publications

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“…[32] Self-reported depressive and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). [33] A subscale score of ≥11 on the HADS was taken to indicate significant depressive or anxiety symptoms.…”

Section: Methodsmentioning

confidence: 99%

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Parkinson's disease motor subtypes and mood

et al. 2011

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Section: Methodsmentioning

confidence: 99%

“…'Anxious-Depressed' (8.6%), 'Depressed' (9.0%) and 'Anxious' (22%), while a fourth group (60.4%) comprised patients with low levels of psychiatric symptomatology [32]. Activities of daily living and motor function were assessed using the UPDRS parts II and III [35] and disease stage with the Hoehn and Yahr Scale.…”

Section: Methodsmentioning

confidence: 99%

Parkinson's disease motor subtypes and mood

et al. 2011

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“…However in patients with early untreated PD, hallucinations were much less prevalent (16), suggesting that probably both age and dopaminergic agents are risk factors for suffering hallucinations. On the other hand, anxiety disorders decrease with age (35).…”

Section: Discussionmentioning

confidence: 99%

“…The severity but not the duration of PD is positively related to anxiety. Anxiety disorders decrease with age and young onset PD patients are more likely to experience anxiety than the late onset ones (35).…”

Section: Discussionmentioning

confidence: 99%

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Neuropsychiatric symptoms and associated caregiver stress in geriatric patients with Parkinson’s disease

2015

neurol neurosci

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Objectives: In Parkinson´s disease, researchers are becoming increasingly aware of the need to include the assessment of behavioural and psychological symptoms as important outcome measures in clinical trials. Besides, clinicians are starting to recognise the need to identify and manage these symptoms in addition to the motor ones. Our objective is to explore the presence of neuropsychiatric symptoms in geriatric patients with Parkinson and the associated distress in their caregivers.Methods: 100 patients with PD ageing 75 years old or more (50 PD without dementia and 50 PD Dementia (PDD) were assessed using the 10-item Neuropsychiatric Inventory-questionnaire (NPI-Q), and the NPI Caregiver Distress Scale (NPI-D). Results:The mean total NPI score was 12.9. At least one neuropsychiatric symptom was present in more than 80% of participants. Within PDD patients about 89% suffered at least one NPI symptom, 70% suffered at least 2 symptoms and one of those symptoms had an intensity scoring 4 of higher in more than 50%. Numbers in PD patients without dementia were significantly lower, though more than 50% of patients had at least 2 symptoms. The most frequent symptom was depression, followed by apathy, anxiety, depression and hallucinations. Antiparkinsonian agents can exacerbate psychotic symptoms. Nearly 60% of caregivers reported suffering a moderate to severe level of stress due to these symptoms. Symptoms causing more stress were agitation/aggression followed by hallucinations and irritability/lability. Conclusions:Neuropsychiatric symptoms are frequent in geriatric patients with PD -specially in patients with PDD-and lead to moderate to severe caregiver distress.

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Frequency, prevalence, incidence and risk factors associated with visual hallucinations in a sample of patients with Parkinson's disease: a longitudinal 4‐year study

Gibson

Mottram

Burn

et al. 2012

Int J Geriat Psychiatry

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104

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When examined longitudinally, VHs affect more patients than is commonly assumed in cross-sectional prevalence studies. Clinicians should routinely screen for VHs throughout the disease course. Disease duration, impairment in activities of daily living and anxiety presented as co-morbidities associated with VHs in PD, and therefore those presenting with VHs should be screened for anxiety disorder and vice versa.

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Depression and anxiety related subtypes in Parkinson's disease

Cited by 160 publications

References 42 publications

Parkinson's disease motor subtypes and mood

Parkinson's disease motor subtypes and mood

Neuropsychiatric symptoms and associated caregiver stress in geriatric patients with Parkinson’s disease

Frequency, prevalence, incidence and risk factors associated with visual hallucinations in a sample of patients with Parkinson's disease: a longitudinal 4‐year study

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