Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics

Yuan, Xiaomin; Chen, Biqing; Duan, Zhenglan; Xia, Ziqian; Ding, Yang; Chen, Tuo; Liu, Huize; Wang, Baosheng; Yang, Bo‐Lin; Wang, Xiaoyong; Liu, Shijia; Zhou, Jin‐Yong; Liu, Yajun; Wang, Qiong; Zheng, Shen; Xiao, Jun; Shang, Hongtao; Liu, Weiwei; Shi, Guo‐Ping; Zhu, Lei; Chen, Yugen

doi:10.1080/19490976.2021.1987779

Cited by 83 publications

(70 citation statements)

References 51 publications

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“…Patients with IBD present with certain neuropsychiatric disorders such as anxiety and depression, and cognitive decline ( Dancey et al., 2009 ; Yuan et al., 2021 ), the severity of which are positively correlated with the severity of the disease ( Clarke et al., 2020 ); however, the mechanism of this correlation remains unclear. It is well known that pathogenic E. coli plays an important role in the development of IBD ( Darfeuille-Michaud et al., 2004 ; Kotlowski et al., 2007 ; Palmela et al., 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease-associated Escherichia coli strain LF82 in the damage of gut and cognition of honeybees

Chang

Chen

Zhong

et al. 2022

Front. Cell. Infect. Microbiol.

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Patients with inflammatory bowel disease (IBD) are often accompanied with some cognitive impairment, but the mechanism is unclear. By orally exposing honeybees (Apis mellifera) to IBD-associated Escherichia coli LF82 (LF82), and non-pathogenic Escherichia coli MG1655 (MG1655) as the normal strain, we investigated whether and how LF82 induces enteritis-like manifestations and cognitive behavioral modifications in honeybees using multiparametric analysis. LF82 significantly increased gut permeability, impaired learning and memory ability in olfactory proboscis extension response conditioning, and shortened the lifespan of honeybees. Compared to MG1655, LF82 reduced the levels of tryptophan metabolism pathway substances in the honeybee gut. LF82 also upregulated genes involved in immune and apoptosis-related pathways and downregulated genes involved in G protein-coupled receptors in the honeybee brain. In conclusion, LF82 can induce enteritis-like manifestations and cognition impairment through gut metabolites and brain transcriptome alteration in honeybees. Honeybees can serve as a novel potential model to study the microbiota-gut-brain interaction in IBD condition.

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Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease-associated Escherichia coli strain LF82 in the damage of gut and cognition of honeybees

Chang

Chen

Zhong

et al. 2022

Front. Cell. Infect. Microbiol.

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“…L-Pipecolic acid (Compound CID: 439227) is an intermediate of L-lysine catabolism, and its central injection is reported to exert a hypnotic effect on the brain 19 . Moreover, it plays an important role in medical issues, rhizosphere ecology, decontamination of polluted soils, nutrient acquisition and plant resistance [20][21][22][23] . At the same time, besides coumarin and volatile oil in Angelica, there were still other secondary metabolites with high content, pharmacological effects and application value.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics analysis reveals metabolite changes during freeze-drying and heat drying of Angelica dahuric

Yan

Jiang

Chen³

et al. 2022

Preprint

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Angelica dahurica (Angelica dahurica Fisch. ex Hoffm.) is a traditional Chinese medicine with active ingredients, including coumarins and volatile oil. Drying is closely associated with the qualities of Chinese medicinal materials. An increasing body of evidence suggests that coumarin content is upregulated with increased temperature within a certain range; however, the underlying mechanism remains unclear. This study sought to determine the key differential metabolites and metabolic pathways related to this phenomenon. Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) based targeted metabolomics analysis was performed on Angelica dahurica that were freeze-dried and heat dried. 995 metabolites were detected, and 193 differentially metabolites were identified as key differential metabolites, most of which were upregulated under heat drying. Furthermore, the common metabolic pathways of paired comparison groups were performed based on KEEG annotation and enrichment analysis. It is speculated that the increase of coumarin content is caused by phenylalanine pathway activation under moderate heat treatment. This study revealed the large-scale recombination events of metabolites in Angelica dahurica. First, we identified additional active secondary metabolites apart from coumarins, and volatile oil was significantly accumulated in Angelica dahurica. We further explored the specific metabolite changes and mechanism of the phenomenon of coumarin upregulation caused by temperature rise. These results provide a theoretical reference for future research on the composition and processing method of Angelica dahurica.

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“…Studies have confirmed that intestinal microbiota and its metabolites play a variety of important roles and functions in our normal life activities, including nutrient absorption, growth and development, biological barrier, immune regulation, fat metabolism, anti-tumor, etc [45][46][47]. The human intestinal microbiota is stimulated by large number of dietary nutrients to produce bioactive compounds such as bile acids, short-chain fatty acids (SCFA), ammonia, phenols, and endotoxins [18,[48][49][50].…”

Section: Overview Of the Intestinal Microbiotamentioning

confidence: 99%

“…In order to further examine the functions of these microbial groups, multi-omics research is more used. Metatranscriptome is used to detect the structure of functionally active microbial populations at the transcriptional level [51,52]; metaproteome is used to detect protein information translated by functionally active microbial populations [17,53]; metabolome is used to detect metabolite information produced by functionally active microbial populations [46,54].…”

Section: Overview Of the Intestinal Microbiotamentioning

confidence: 99%

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

Deng¹,

Lin²,

Sun³

et al. 2022

Int. J. Biol. Sci.

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Intestinal ischemia/reperfusion (I/R) is a common pathophysiological process in clinical severe patients, and the effect of intestinal I/R injury on the patient's systemic pathophysiological state is far greater than that of primary intestinal injury. In recent years, more and more evidence has shown that intestinal microbiota and its metabolites play an important role in the occurrence, development, diagnosis and treatment of intestinal I/R injury. Intestinal microbiota is regulated by host genes, immune response, diet, drugs and other factors. The metabolism and immune potential of intestinal microbiota determine its important significance in host health and diseases. Therefore, targeting the intestinal microbiota and its metabolites may be an effective therapy for the treatment of intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury. This review focuses on the role of intestinal microbiota and its metabolites in intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury, and summarizes the latest progress in regulating intestinal microbiota to treat intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury.

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Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics

Cited by 83 publications

References 51 publications

Inflammatory bowel disease-associated Escherichia coli strain LF82 in the damage of gut and cognition of honeybees

Inflammatory bowel disease-associated Escherichia coli strain LF82 in the damage of gut and cognition of honeybees

Metabolomics analysis reveals metabolite changes during freeze-drying and heat drying of Angelica dahuric

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

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