Depression and Anxiety Disorders in Covid-19 Survivors: Role of Inflammatory Predictors

Demiryürek, Bekir Enes; Demiryürek, Esra; Çekiç, Deniz; İşsever, Kubilay; Genç, Ahmed Cihad; Yaylacı, Selçuk

doi:10.29399/npa.27698

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…A previous study revealed that the NLR had a strong correlation with anxiety in gastric cancer patients with preoperative treatment (Xu et al, 2016) and stress in multiple sclerosis patients (Al-Hussain et al, 2017). A recent study showed significant differences in the NLR and SII between individuals with depression and those without depression as well as those with and without anxiety, which indicated that anxiety and depression were found to have strong correlations with both the NLR and SII in patients who survived coronavirus disease 2019 (COVID-19) (Demiryürek et al, 2022). Wang et al (2021) also reported that after adjusting for any potential confounding factors, the SII and NLR were still both related to depression.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus

Rias

Tsai

Thato

et al. 2023

Biological Research For Nursing

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Background High-grade inflammation represents a critical contribution to the onset of depression and might be manageable by physical activity (PA). Nevertheless, no study has examined synergistic interactions of insufficient PA and high values of the systemic immune-inflammation index (SII) on psychological problems. Objective We investigated independent and synergistic interactions of insufficient PA and high SII levels on stress, anxiety, and depression in T2DM patients. Methods A cross-sectional research design with 294 T2DM patients was conducted. An XP-100 automated hematology analyzer was used to evaluate inflammatory biomarkers. Depression, Anxiety, and Stress Scale-21 items and a standardized questionnaire about PA were respectively used to measure psychological problems and metabolic equivalent of task (MET)-h/week. Results A multiple linear regression demonstrated that patients with insufficient PA were significantly more likely to have higher stress ( β = 1.84, 95% confidence interval (CI) = 1.03–2.65), anxiety ( β = 1.88, 95% CI = 1.81–2.96), and depression ( β = 2.53, 95% CI = 0.82–4.24) than those with active PA. A high SII level was a key predictor and was most strongly associated with stress ( β = 2.61, 95% CI = 2.02–3.20), anxiety ( β = 3.16, 95% CI = 2.37–3.94), and depression ( β = 3.72, 95% CI = 2.49–4.96) compared to those who had low SII levels. Notably, additive interaction results showed that combining insufficient PA and a high SII level had a significantly escalated 1.71-fold risk of stress, 1.82-fold risk of anxiety, and 2.69-fold risk of depression. Conclusions Active PA and a low SII had a positive synergistic effect of decreasing psychological problems.

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Section: Discussionmentioning

confidence: 99%

Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus

Rias

Tsai

Thato

et al. 2023

Biological Research For Nursing

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show abstract

“…Previous studies confirmed that a high level of the systemic immune-inflammation index (SII) was associated with an increased risk of depression in patients with diabetes mellitus (18), stroke (19), tuberculosis (20), and COVID-19 survivors (21). However, the association of systemic inflammatory response biomarkers with depression risk in the whole non-institutionalized population remains unclear, which limited to generalizable to the general population.…”

Section: Introductionmentioning

confidence: 99%

Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005–2018 analyses

Huan²,

Lin³

et al. 2023

Front. Psychiatry

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Background/AimDepression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response.MethodsBased on the data of the National Health and Nutrition Examination Survey (NHANES), this study included 2,514 depressive and 26,487 non-depressive adults. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were used to quantify systemic inflammation. The multivariate logistic regression and inverse probability weighting methods were used to analyze the effect size of SII and SIRI on the risk of depression.ResultsAfter adjusting for all confounders, the above associations of SII and SIRI with depression risk remained significant (SII, OR = 1.02, 95% CI = 1.01 to 1.02, p = 0.001; SIRI, OR = 1.06, 95% CI = 1.01 to 1.10, p = 0.016). Each 100-unit increase in SII was associated with a 2% increase in the risk of depression, while each one-unit increase in SIRI was associated with a 6% increase in the risk of depression.ConclusionSystemic inflammatory biomarkers (SII and SIRI) significantly affected the risk of depression. SII or SIRI can serve as a biomarker of anti-inflammation treatment for depression.

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“…In COVID-19 patients, higher serum ferritin levels are reported in hospitalized (23,24), critically ill patients (25)(26)(27) with more severe illness (23,(28)(29)(30)(31), longer length of hospital stay (32) and in non-survivors (1,25,(33)(34)(35)(36)(37)(38)(39). In addition, one study screened adult COVID-19 survivors (n = 109) for depression and anxiety using Beck Depression and Beck Anxiety Inventories (BDI, BAI) (40,41) on the 15th post-hospitalization day, and reported significant positive correlation between BAI scores and ferritin levels in patients with anxiety (42).…”

Section: Introductionmentioning

confidence: 99%

Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions

Abulseoud

Yehia²,

Egol³

et al. 2022

Front. Psychiatry

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We examined the effects of psychiatric comorbidity, sex, and ICU admission on serum ferritin concentration in 628 elderly patients (79.7 ± 8.5 years) with positive SARS-CoV-2 PCR test. Hospitalization was required in 96% of patients and 17% required ICU admission. Patients with COVID-19 and psychiatric comorbidities (n = 212) compared to patients without psychiatric comorbidities (n = 416) had significantly lower ferritin concentration (570.4 ± 900.1 vs. 744.1 ± 965, P = 0.029), a greater incidence of delirium (22.6 vs. 14.4%, P = 0.013) and higher mortality (35.3 vs. 27.6%, P = 0.015). Furthermore, we found significant effects for sex (P = 0.002) and ICU admission (P = 0.007). Among patients without comorbid psychiatric conditions, males had significantly higher ferritin compared to females (1,098.3 ± 78.4 vs. 651.5 ± 94.4, P < 0.001). ICU patients without comorbid psychiatric conditions had significantly higher serum ferritin compared to ICU patients with comorbid psychiatric conditions: (1,126.6 ± 110.7 vs. 668.6 ± 156.5, P < 0.001). Our results suggest that the presence of comorbid psychiatric conditions in elderly patients with COVID-19 is associated with higher rates of delirium and mortality and lower ferritin levels during severe illness. Whether high serum ferritin is protective during severe infection requires further investigation.

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Depression and Anxiety Disorders in Covid-19 Survivors: Role of Inflammatory Predictors

Cited by 5 publications

References 24 publications

Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus

Synergistic Interactions of Insufficient Physical Activity and a High Systemic Immune-Inflammation Index on Psychological Problems in Indonesians With Type 2 Diabetes Mellitus

Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005–2018 analyses

Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions

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