Depression and adherence to treatment in diabetic children and adolescents: a systematic review and meta-analysis of observational studies

Abstract

This study showed moderate associations between depression and poor treatment adherence. Targeting behaviour and social environments, however, may ultimately provide more cost-effective health gains than targeting depressive symptoms.

Social Support and Adherence to Treatment in Hypertensive Patients: A Meta-Analysis

“…In fact, depression is related to poor relationships and feelings of social isolation and to non-adherence to medical treatment across a range of chronic diseases, including hypertension [70][71][72][73][74]. Importantly, Krousel-Wood et al [44] found that at the univariate level both social support and depression were significantly related to adherence, whereas at the multivariate level (i.e., after controlling for their reciprocal effects) only depression remained a significant predictor of adherence.…”

Diabetes Mellitus

“…Feelings of depression may be negatively related to adherence in children (Hood et al, 2006 ;Kongkaew, Jampachaisri, Chaturongkul, & Scholfi eld, 2014 ). Experiencing life stress and anxiety also can negatively impact adherence (Herzer & Hood, 2010 ).…”

Anxiety and depressive disorders in children and adolescents suffering from diabetes mellitus

“…The link between depression and DM can also have biological connections such as dyslipidaemia, which seems to be a biological correlate of depression and DM in adolescents 19 . There is preliminary evidence that higher levels of depression are associated with metabolic abnormalities and systemic inflammation 46 . T1D may contribute to emotional and biological disruptions, so that depression exacerbates dyslipidaemia 46 .…”

“…There is preliminary evidence that higher levels of depression are associated with metabolic abnormalities and systemic inflammation 46 . T1D may contribute to emotional and biological disruptions, so that depression exacerbates dyslipidaemia 46 . It is also assumed that depression itself is a moderate risk factor for developing DM in young adults, either directly or indirectly [47][48][49] .…”