Depression and 18-Month Prognosis After Myocardial Infarction

Frasure-Smith, Nancy; Lespérance, François; Talajic, Mario

doi:10.1097/00008483-199507000-00007

Cited by 447 publications

(644 citation statements)

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“…The present study supports this conclusion. Also supportive of this is previous research that reported an increased mortality risk for the (full version) BDI scale when compared to an interview for DSM-IIIR criteria (OR=3.64 for interview vs. OR=7.82 for BDI) [4]. These authors also noted that the diagnostic interview did not significantly improve the predictive ability of a model predicting mortality, but the BDI did.…”

Section: Discussionsupporting

confidence: 67%

“…Morbidity and mortality post-AMI are determined by a number of independent risk factors, including extent of coronary artery disease, infarct size, severity of left ventricular dysfunction, and depression [2][3][4][5][6]. Depression following ACS has been found to be an important risk factor for further coronary events, with even low levels of depression having a significant effect on mortality risk [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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The Hospital Anxiety and Depression Scale depression subscale, but not the Beck Depression Inventory-Fast Scale, identifies patients with acute coronary syndrome at elevated risk of 1-year mortality

Doyle

McGee

Harpe

et al. 2006

Journal of Psychosomatic Research

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

The Hospital Anxiety and Depression Scale depression subscale, but not the Beck Depression Inventory-Fast Scale, identifies patients with acute coronary syndrome at elevated risk of 1-year mortality

Doyle

McGee

Harpe

et al. 2006

Journal of Psychosomatic Research

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“…49 In addition, depression appears to be a risk factor for both morbidity and mortality of coronary heart disease, 50,51 and significantly increases mortality after survival of a myocardial infarction. 52,53,54 On the other hand, depression is also a predisposing factor for coronary heart disease. 15,55 Furthermore, central stress regulation systems like the HPA system seem to play a crucial role in influencing morbidity and mortality of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism

et al. 2006

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Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic-pituitary-adrenocortical (HPA) system, which shows hyperactivity in the majority of patients with major depression. The ACE gene, known to be associated with cardiovascular disorders, which in turn are accompanied with an increased susceptibility for depression, is therefore a promising candidate gene for affective disorders. We investigated the genetic association between 35 single-nucleotide polymorphisms (SNPs) and an insertion/deletion (I/D)-polymorphism in the ACE gene and the susceptibility for unipolar major depression together with the genetic association with ACE serum activity and functional parameters of the HPA system. Two independent case/control samples with a total of 843 unrelated unipolar depressed patients and 1479 healthy controls were investigated. A case/control sample was screened to detect genetic associations with unipolar major depression. In addition, a replication sample was used to confirm the detected associations and to further investigate functional consequences of the genetic variants associated with depression. In the screening sample, two SNPs within the ACE gene were significantly associated with unipolar major depression. The association with unipolar major depression of one SNP (rs4291) located in the promoter region of the ACE gene was confirmed in our replication sample. The T-allele of this SNP was associated with depression and depressed T-allele carriers showed higher ACE serum activity and HPA-axis hyperactivity. Variants of the ACE gene such as SNP rs4291 are suggested susceptibility factors for unipolar major depression. We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease.

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“…Patients should be screened carefully on a regular basis (i.e. annually), as research in other cardiovascular populations [4,5,6] shows that even mild symptoms of depression are predictive for morbidity and mortality. Besides more traditional treatment with antidepressants and/or cognitive or interpersonal therapy, interventions could also target important correlates of symptoms of depression [3,7,8,91.…”

Section: Discussionmentioning

confidence: 99%

“…Depression is an important parameter of psychosocia1 functioning and a risk factor for poor outcome in a number of chronically ill patient populations [2, 31. Depression is also a risk factor for morbidity and mortality in cardiovascular disease [4,5,61. It negatively affects the quality of life of patients and families; it is a risk factor for noncompliance with medical treatment [2]; and it has economic implications for the patient and society [7,8,91.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of depression symptoms at 10 years after heart transplantation: continuous attention required

et al. 2004

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Prevalence and correlates of depression symptoms at 10 years after heart -- transplantation: continuous attention requiredAbstract This study investigates the presence and correlates of symptoms of depression at 5 and 10 years after heart transplantation, with particular attention given to patients showing symptoms at both time points. Prevalence of depression symptoms were studied in 41 patients, prospectively, at 5 and 10 years after heart transplantation. We examined potential correlates of depression symptoms (i.e. worse functional capacity, inadequate coping mechanisms and lack of social contacts) 10 years after transplantation. The prevalence of depression symptoms was 30% at 5 years and 22% at 10 years. Of the 41 patients, 20% were depressed at both time points. Those patients had significantly higher scores on passive coping and had significantly lower club membership. They also tended to have more negative emotions (i.e. anger, hostility and irritability) and less engagement in sports activities. Functional capacity was not different. Depression symptoms were prevalent and persistent in the longterm after heart transplantation. This study opens perspectives for beyond-standard pharmacological and psychotherapeutic treatment for depression, i.e. training patients who are using passive coping to use problem-solving capacities instead and motivating them to engage in social life and sports activities.

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Depression and 18-Month Prognosis After Myocardial Infarction

Cited by 447 publications

References 0 publications

The Hospital Anxiety and Depression Scale depression subscale, but not the Beck Depression Inventory-Fast Scale, identifies patients with acute coronary syndrome at elevated risk of 1-year mortality

The Hospital Anxiety and Depression Scale depression subscale, but not the Beck Depression Inventory-Fast Scale, identifies patients with acute coronary syndrome at elevated risk of 1-year mortality

Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism

Prevalence and correlates of depression symptoms at 10 years after heart transplantation: continuous attention required

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