Depression, abuse and its relationship to interstitial cystitis

Goldstein, Howard; Safaeian, Pegah; Garrod, K.; Finamore, Peter S.; Kellogg‐Spadt, Susan; Whitmore, Kristene

doi:10.1007/s00192-008-0712-x

Cited by 43 publications

(44 citation statements)

References 25 publications

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“…These findings from a community-based sample are consistent with reports from clinical populations that compare rates to healthy controls[2]. The prevalence of urological symptoms among the twins was 7.8%, falling within the limits of previously reported estimates from community studies of women[24-26].…”

Section: Discussionsupporting

confidence: 89%

Psychological distress in twins with urological symptoms

Wright

Noonan

Ahumada

et al. 2010

General Hospital Psychiatry

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Objective Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic pain condition with unclear underlying etiology. Our objectives were to determine if psychological distress was higher in twins with urological symptoms commonly found in IC/PBS than twins without, and if so, did familial influences contribute to this association. Method Data from 1,165 female twins in a community-based sample were used. Urological symptoms, symptoms of posttraumatic stress disorder (PTSD), depression, anxiety, and perceived stress were assessed with standardized questionnaires. Generalized estimating equation regression models were used to examine the relationship between psychological distress and urological symptoms. Results Compared to unaffected twins, twins with urological symptoms were more likely to report PTSD symptoms (OR = 3.9; CI = 2.6-5.8), depression (OR = 3.1; CI = 2.0-5.0), anxiety (OR = 3.4; CI = 2.3-5.2), and perceived stress (OR = 3.2; CI = 2.1-4.9). After adjusting for familial influences, the within-pair effects remained significant for PTSD symptoms (OR = 2.2; CI = 1.2-3.8) and perceived stress (OR = 2.2; CI = 1.2-3.8). Conclusion Familial influences partially explained the relationship between indicators of psychological distress and urological symptoms. Future research should examine shared environmental and genetic mechanisms that may further explain this relationship and improve diagnosis and treatment of this unexplained clinical condition.

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Section: Discussionsupporting

confidence: 89%

Psychological distress in twins with urological symptoms

Wright

Noonan

Ahumada

et al. 2010

General Hospital Psychiatry

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“…[1, 12–14] The prevalence of panic disorder co-morbid with BPS/IC has been estimated at 14 %, [1] although studies linking the related problem of irritable bowel syndrome to panic disorder have found panic rates of co-morbidity as high as 46 %. [15] These studies focused on patient samples and therefore the population prevalence of BPS/IC symptoms and co-morbid depression or panic is unknown.…”

Section: Introductionmentioning

confidence: 99%

“…[7, 9, 16–22] Among patients being treated for pain conditions, depression is associated with more pain complaints, worse pain, longer duration of pain, and a greater likelihood of non-recovery. [4, 12] Among patients with depression, pain is associated with a delay in diagnosis and treatment, more severe depression, functional limitations, and worse health-related quality of life. Pain has a strong, negative impact on both the recognition and treatment of depression.…”

Section: Introductionmentioning

confidence: 99%

Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample

Watkins

Eberhart

Hilton

et al. 2011

General Hospital Psychiatry

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Objective-We report the population prevalence of probable depressive disorders and current panic attacks in women with bladder pain syndrome/interstitial cystitis (BPS/IC) symptoms and describe their characteristics and access care.Method-We conducted a telephone screening of 146,231 households and phone interviews with women with BPS/IC symptoms. A weighted probability sample of 1,469 women who met criteria for BPS/IC was identified. Measures of BPS/IC severity, depressive symptoms, panic attacks, and treatment utilization were administered. T-tests and chi-square tests were run to examine differences between groups.Results-Over one-third of the sample (N = 536) had a probable diagnosis of depression and 52% (N = 776) reported recent panic attacks. Women with a probable diagnosis of depression or current panic attacks reported worse functioning, increased pain and were less likely to work because of bladder pain.Conclusions-In this community-based sample, rates of probable current depression and panic attacks are high and there is considerable unmet need for treatment. These findings suggest that clinicians should be alert to complaints of bladder pain in patients seeking treatment for depressive

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“…Patients reporting concomitant pain and depression have a reduced likelihood of recovery and longer symptom duration. 23 With depression estimates in IC/BPS varying from 5% to greater than 50% of samples, 12,24,25 and pain as a cardinal symptom, 2 identification of SI in tertiary care is recommended. Although depression in this study has a stronger association with SI than catastrophizing, depression and catastrophizing likely manifest in tandem.…”

mentioning

confidence: 99%

Depression and catastrophizing predict suicidal ideation in tertiary care patients with interstitial cystitis/bladder pain syndrome

Tripp

Nickel

Krsmanovic

et al. 2016

CUAJ

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Introduction: We sought to evaluate psychosocial factors as predictors of suicidal ideation (SI) in a tertiary care outpatient sample of women suffering from interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: The patients are women managed at tertiary care centres (n=190). Controls were recruited from the community (n=117). Both groups completed questionnaires on demographics, pain (McGill Pain Questionnaire), IC/BPS symptoms, and psychological variables. Univariate and multivariate hierarchical regression modelling was conducted to examine the strength of associations and unique effects of psychosocial variables on patient SI. Results: Compared to 6% in healthy controls, 23% of patients endorsed SI in the past two weeks. Correlations between SI, depression, and catastrophizing across controls and cases show that for controls, SI is associated with greater pain (0.31; p<0.01) and depression only (0.59; p<0.01). For tertiary care centre cases, SI is associated with pain (0.24; p<0.01), depression (0.64; p<0.01), and catastrophizing (0.35; p<0.01). Regression analyses indicated that psychosocial variables accounted for a significant amount of variance over and above IC/BPS symptoms. Catastrophizing (i.e., helplessness) about pain and depression were significant univariate predictors of SI, but only depression predicted SI in multivariable analyses. Conclusions: Limitations of this study include its cross-sectional design and primarily correlation-based statistics. The present study is the first to implicate multiple psychosocial risk factors over and above IC/BPS-specific symptoms and patient pain experience in SI in women with IC/BPS. Depression in particular is uniquely important in predicting suicidality. These results support a multidisciplinary, proactive approach to IC/BPS involving not only treatment of disease symptoms, but also early detection/treatment of associated psychosocial problems.

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Depression, abuse and its relationship to interstitial cystitis

Cited by 43 publications

References 25 publications

Psychological distress in twins with urological symptoms

Psychological distress in twins with urological symptoms

Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample

Depression and catastrophizing predict suicidal ideation in tertiary care patients with interstitial cystitis/bladder pain syndrome

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