Depressed Multiple-Suicide­Attempters – A High-Risk Phenotype

Abstract

Our data suggest that multiple-suicide attempters require careful evaluation as their behavior can have serious medical consequences.

Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt

“…A trend toward higher total MADRS scores among attempters in comparison with non‐attempters observed in our study is also consistent with multiple reports that depression is associated with suicidal ideations . It is important to note that depression is also strongly associated with suicide attempts and completed suicides .…”

“…Consistent with other observations , the current study in combat veterans showed that persons with a previous a history of suicidal behaviour continue to demonstrate higher suicidal ideation than persons without a history of suicide attempt. This suggests suicidal ideation may be a stable trait.…”

Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression

“…In contrast, nightmares have been found to be more common among patients who have attempted suicide [35]. It might be suggested that nightmares could be considered an important indicator of suicide attempts in depressed patients [57]. In addition, sleep disorders were found to increase the risk of completed suicide, but the effect values were on the margins of statistical significance.…”

GABAA Receptor Subunit Transcriptional Regulation, Expression Organization, and Mediated Calmodulin Signaling in Prefrontal Cortex of Rats Showing Testosterone-Mediated Impulsive Behavior

“…From a clinical perspective, GABA A receptors are more frequently used as therapeutic targets when treating disorders such as anxiety and epilepsy (Arin et al, 2018). In the future, it will be interesting to translate this study to a human level to examine if GABA receptor functions are altered during impulsivity, particularly in suicidal people where this interaction has been shown to play a critical role in attempted and completed suicide (Sher et al, 2017;Lenz et al, 2019). There were a few limitations to our study.…”