Depressed Lymphocyte Function After Bereavement

Bartrop, Roger; Lazarus, L.; Luckhurst, E; Kiloh, L. G.; Penny, Ronald

doi:10.1016/s0140-6736(77)92780-5

Cited by 879 publications

(275 citation statements)

References 8 publications

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“…While such effects have been demonstrated in a number of animal studies (Monjan, 1981;Laudenslager et al, 1983), the human literature is more limited (Bartrop et al, 1977;Palmbald, 1981;Jemmott et al, 1983). In earlier studies, we found that medical students had significantly poorer natural killer-cell (NK) activity in blood samples obtained during examinations, in contrast to baseline samples drawn 1 month previously (Kiecolt-Glaser et al, 1984a).…”

Section: Introductionmentioning

confidence: 83%

Distress and DNA repair in human lymphocytes

et al. 1985

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This research assessed differences in DNA repair in lymphocytes from highand low-distressed individuals. A median split on Minnesota Multiphasic Personality Inventory (MMPI) Scale 2 divided 28 newly admitted nonpsychotic psychiatric inpatients into high-and low-distress subgroups.The high-distress subgroup had significantly poorer DNA repair in lymphocytes exposed to X-irradiation than low-distress subjects. We also found that lymphocytes obtained from this psychiatric sample had significantly poorer DATA repair than lymphocytes from nonpsychiatric control subjects when compared 5 hr after X-irradiation. A high level of distress therefore appears to be associated with significant dysfunctional differences at the molecular level which may have important implications for health. These data provide evidence for a direct pathway through which distress could influence the incidence of cancer.

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Section: Introductionmentioning

confidence: 83%

Distress and DNA repair in human lymphocytes

et al. 1985

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“…Bereavement has been associated with in vitro functional immune measures such as decreased natural killer cell cytotoxicity and poorer lymphocyte proliferation to mitogen (Bartrop et al, 1977;Goodkin et al, 1996;Irwin et al, 1987;Kemeny et al, 1995;Schleifer et al, 1983;Zisook et al, 1994). The present findings regarding marital status and satisfaction also extend the results of previous studies showing that poorer marital quality, in terms of adjustment and negative marital interactions, are associated with inferior functional immunity evidenced through reduced proliferation to some mitogens, poorer latent virus control (Kiecolt- Glaser et al, 1987;Kiecolt-Glaser et al, 1997;Kiecolt-Glaser et al, 1988;Kiecolt-Glaser et al, 1993), and weaker natural killer cell cytotoxicity (Miller et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Phillips

Carroll

Burns

et al. 2006

Brain, Behavior, and Immunity

100

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Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N = 184). Antibody response was assessed at baseline, and at one and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains.However, bereavement in the year prior to vaccination was negatively associated with the one-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at one month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples.This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group.

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“…Inclusion criteria were: published between January 1970 and December 2006, with this starting date chosen because studies investigating the effect of psychological stress on the development of morbid conditions were first published in that decade 15,16 ; prospective cohort design, this study design being one of the most appropriate for assessing causality 17 while taking into consideration the major issue of temporality, i.e., exposure prior to disease; 18 to 64 year-old normotensive adults; main exposure measured through reactivity or recovery, reactivity is the difference between blood pressure during the stressor task and baseline 18 and recovery is blood pressure measured after a stressful task 19 ; dichotomous outcome as arterial hypertension or increase in systolic and/or diastolic blood pressure ≥ 3.5mmHg; and reporting relative risks, hazard ratios or odds ratios (OR).…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Effect of psychological stress on blood pressure increase: a meta-analysis of cohort studies

et al. 2009

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Studies have suggested that chronic exposure to stress may have an influence on increased blood pressure. A systematic review followed by a meta-analysis was conducted aiming to assess the effect of psychological stress on blood pressure increase. Research was mainly conducted in Ingenta, Psycinfo, PubMed, Scopus and Web of Science. Inclusion criteria were: published in any language; from January 1970 to December 2006; prospective cohort design; adults; main exposure psychological/emotional stress; outcome arterial hypertension or blood pressure increase > 3.5mmHg. A total of 2,043 studies were found, of which 110 were cohort studies. Of these, six were eligible and yielded 23 comparison groups and 34,556 subjects. Median follow-up time and loss to follow-up were 11.5 years and 21%. Results showed individuals who had stronger responses to stressor tasks were 21% more likely to develop blood pressure increase when compared to those with less strong responses (OR: 1.21; 95%CI: 1.14-1.28; p < 0.001). Although the magnitude of effect was relatively small, results suggest the relevance of the control of psychological stress to the non-therapeutic management of high blood pressure.

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Depressed Lymphocyte Function After Bereavement

Cited by 879 publications

References 8 publications

Distress and DNA repair in human lymphocytes

Distress and DNA repair in human lymphocytes

Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Effect of psychological stress on blood pressure increase: a meta-analysis of cohort studies

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