Depressed Heart Rate Variability as an Independent Predictor of Death in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy

Ponikowski, Piotr; Anker, Stefan D.; Chua, Tuan Peng; Szełemej, Roman; Piepoli, Massimo F; Adamopoulos, Stamatis; Webb-Peploe, Katharine; Harrington, Derek; Banasiak, Waldemar; Wrabec, Krzysztof; Coats, Andrew J.S.

doi:10.1016/s0002-9149(97)00215-4

Cited by 431 publications

(276 citation statements)

References 24 publications

Supporting

Mentioning

249

Contrasting

Unclassified

Order By: Relevance

“…[1] It goes along with sympathetic activation; however the pattern of activation differs from obstructive apnea. [2] The resulting blood pressure elevation is blocked by the ganglionic blocker trimethaphan and thus neuronally mediated.…”

Section: Introductionmentioning

confidence: 99%

Spontanous periodic breathing is associated with sympathetic hyperreactivity and baroreceptor dysfunction in hypertension

Binggeli

Sudano²,

Corti³

et al. 2010

Journal of Hypertension

View full text Add to dashboard Cite

OBJECTIVES: Intermittent periods of hypoxemia such as during periodic breathing are associated with hypertension and increased sympathetic activity. In patients with sleep apnea syndrome, hypertension is common. Treating apnea improves hypertension and reduces sympathetic outflow. The aim of the present study was to investigate the phenomenon and mechanisms of spontaneous periodic breathing in patients with hypertension. METHOD: We examined 43 hypertensive patients with untreated hypertension without left-ventricular dysfunction, heart failure or sleep apnea syndrome. Muscle sympathetic nerve activity (MSA), heart rate (HR), blood pressure (BP) and respiration were continuously recorded at rest and during cold-pressor testing. Oxygen and a CO2-enriched gas were used to test central and peripheral chemoreceptors, respectively. Baroreceptor gain was measured using the alpha method. RESULTS: Seven out of 43 patients showed spontaneous periodic breathing while awake. No difference in MSA, HR and BP was seen between patients with and without periodic breathing at rest except the breathing pattern. However, the cold-pressor test caused a larger increase of MSA in patients with periodic breathing (203 +/-62 vs. 62 +/-8%, P < 0.0001 by ANOVA), as well as systolic (46 +/-6 vs. 25 +/-3 mmHg, P = 0.002) and diastolic BP (26 +/-5 vs. 12 +/-1 mmHg, P = 0.004, ANOVA). Baroreceptor gain was markedly higher in patients with periodic breathing. Chemoreceptor sensitivity was comparable. CONCLUSION: Spontaneous periodic breathing is relatively common in patients with hypertension and is associated with greatly enhanced responses to cold-pressor testing. We suggest increased baroreceptor gain and sympathetic outflow as a cause for the oscillatory respiration pattern via barorespiratory coupling.

show abstract

Section: Introductionmentioning

confidence: 99%

Spontanous periodic breathing is associated with sympathetic hyperreactivity and baroreceptor dysfunction in hypertension

Binggeli

Sudano²,

Corti³

et al. 2010

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…In the last five years, HRV has been shown to of important prognostic value in CHF 149,[152][153][154] . Despite the small number of patients in the series, the largest consisting of 102 patients 153 , the results have been consistent.…”

Section: Autonomic Dysfunctionmentioning

confidence: 99%

“…Recently, Ponikowski et al 153 showed that HRV is an independent prognostic factor in patients with CHF secondary to ischemic or idiopathic dilated cardiomyopathy. Patients with SDNN (another index of HRV in the time domain) inferior to 100 ms had a 3.8-time higher risk of death than those whose indices are higher than that value.…”

Section: Autonomic Dysfunctionmentioning

confidence: 99%

Prognostic factors in patients with congestive heart failure

Villacorta¹,

Mesquita²

1999

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

“…[2][3] Depressed SDNN is reported to be an independent risk factor for a poor prognosis in patients with congestive heart failure. [4] Some researchers have also reported that SDNN predicts mortality from all causes in middle-aged and elderly men. [5][6] A study on progression of cardiac autonomic dysfunction in type 2 diabetes has reported that SDNN could be a suitable marker in quantifying cardiac autonomic dysfunction in relation to cardiovascular disease in type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Correlates of SDNN heart rate variability in healthy subjects and subjects with type 2 diabetes mellitus

Nk¹,

Adhikari²,

Poornima³

et al. 2015

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Introduction: Standard deviation of R-R intervals (SDNN) predicts mortality in variety of clinical conditions. But little is known about correlates of SDNN. Objective: To investigate correlates of SDNN in healthy subjects and with type 2 diabetes. Materials and Methods: 115 male subjects with type 2 diabetes and 87 controls were studied. In them heart rate (HR), blood pressure (BP), body mass index (BMI), Q -Tc and SDNN were measured. Pearson correlation coefficient and unpaired t test were used for data analysis. P < 0.05 was considered significant. Results: In controls, SDNN was negatively correlating with age and HR (p < 0.05, <0.001 respectively). In subjects with type 2 diabetes, SDNN was negatively correlating with HR, diastolic blood pressure, Q-Tc and duration of diabetes (p < 0.0001, < 0.01, = 0.014, < 0.05 respectively); and was positively correlating with BMI (p < 0.05). Conclusion: Higher HR, DBP, prolonged Q-T interval and duration of diabetes are associated with reduced SDNN in subjects with type 2 diabetes. In them BMI could be a confounding factor while assessing cardiac autonomic dysfunction employing SDNN. In healthy subjects high HR and age are associated with reduced SDNN.

show abstract

Depressed Heart Rate Variability as an Independent Predictor of Death in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy

Cited by 431 publications

References 24 publications

Spontanous periodic breathing is associated with sympathetic hyperreactivity and baroreceptor dysfunction in hypertension

Spontanous periodic breathing is associated with sympathetic hyperreactivity and baroreceptor dysfunction in hypertension

Prognostic factors in patients with congestive heart failure

Correlates of SDNN heart rate variability in healthy subjects and subjects with type 2 diabetes mellitus

Contact Info

Product

Resources

About