Depressed DHEA and increased sickness response behaviors in lame dairy cows with inflammatory foot lesions

Almeida, Patrícia E. de; Weber, P.S.D.; Burton, Jeanne L.; Zanella, Adroaldo José

doi:10.1016/j.domaniend.2006.11.006

Cited by 85 publications

(87 citation statements)

References 62 publications

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“…The current study demonstrated that lame cows spend less time elevated on their feet, due in part to spending less time standing and walking compared with non lame cows. This is in agreement with the results of Almeida et al (2008) and Gonzales et al (2008) who found that lameness significantly decreases feeding time. As shown in many other studies, the age of the cow and the time of year have a large effect on levels of lameness.…”

Section: Lamenesssupporting

confidence: 83%

Dairy Cattle Welfare Status Measured by Animal-Linked Parameters Under Tunisian Rearing Conditions

M’Hamdi¹,

Frouja²,

Bouallegue³

et al. 2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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Section: Lamenesssupporting

confidence: 83%

Dairy Cattle Welfare Status Measured by Animal-Linked Parameters Under Tunisian Rearing Conditions

M’Hamdi¹,

Frouja²,

Bouallegue³

et al. 2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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“…For instance, the mammary gland can use DHEA to make androstene-3b,17b-diol (AED; Belvedere et al 1996), a metabolite with immunoenhancing activity (Loria et al 1996). In addition, it was recently reported that cows with inflammatory foot lesions showed a 23% decrease in serum DHEA concentrations (Almeida et al 2007), suggesting that DHEA is implicated in the inflammation process also in the bovine. Those observations, however, are not sufficient to hypothesise a biological role for DHEA in that species, and a better characterisation of the DHEA secretion is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Then, plasma DHEA and AED concentrations are higher in late pregnancy and drop suddenly after parturition (Gabai et al 2004). Finally, it was recently reported that cows with inflammatory foot lesions showed a 23% decrease in serum DHEA concentrations (Almeida et al 2007), suggesting that DHEA is implicated in the inflammation process also in the bovine.…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Marinelli

Trevisi

Dalt

et al. 2007

Journal of Endocrinology

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This paper describes the episodic release and response to adrenal stimulation of cortisol and dehydroepiandrosterone (DHEA) in cows. Observations made in samples taken every 10 min for 8 h (experiment 1) showed that plasma DHEA was significantly greater (P!0 . 001) than DHEA-S, and release of these steroids was episodic and variable between animals (P!0 . 01). No relationship was found between DHEA and cortisol. Significant (P!0 . 001) DHEA-sulphate (DHEA-S) versus cortisol (RZK0 . 264) and DHEA-S versus DHEA (RZ0 . 200) correlations were found. DHEA and DHEA-S were not affected by a single ACTH challenge (experiment 2). In experiment 3, cortisol and DHEA secretions in response to prolonged ACTH administration (every 12 h for 6 days) were studied. On day 7, the episodic cortisol and DHEA release and response to the opioid antagonist naloxone were studied in blood samples taken every 10 min for 8 h. Animals were injected with naloxone after 4 h. A significant increase (P!0 . 05) in mean circulating DHEA and DHEA pulse amplitude was observed during frequent sampling following ACTH treatment. DHEA and DHEA-S plasma concentrations were not affected following luteal regression (experiment 4). The effect of milk secretion around parturition on DHEA secretion was studied in dry and continuously milked cows (experiment 5). Plasma DHEA was significantly lower (P!0 . 05) in milked cows. In the cow, ACTH is not an important DHEA secretagogue. Adrenal contribution to plasma DHEA is scarce. Likely, the placenta is the most important source of DHEA, and the lactating mammary gland can affect circulating DHEA levels. Investigation about the DHEA biological role in cows should be focused around parturition.

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“…Lameness is a major health and welfare problem in modern dairy herds (Bruijnis et al, 2012), which negatively affects oestrus expression (Walker et al, 2008), fertility (Bicalho et al, 2007), feeding and rumination (Almeida et al, 2008), milk production (Kamphuis et al, 2013), lying behaviour (Ito et al, 2010;Thomsen et al, 2012) and cow longevity (Thomsen et al, 2004). The mean prevalence of lameness can be high, for example it was 37% in the United Kingdom , 44% in Denmark (Burow et al, 2014) and between 28% and 55% in regions in North America (von Keyserlingk et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Lameness detection via leg-mounted accelerometers on dairy cows on four commercial farms

Thorup

Munksgaard

Robert

et al. 2015

Animal

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Lameness in dairy herds is traditionally detected by visual inspection, which is time-consuming and subjective. Compared with healthy cows, lame cows often spend longer time lying down, walk less and change behaviour around feeding time.Accelerometers measuring cow leg activity may assist farmers in detecting lame cows. On four commercial farms, accelerometer data were derived from hind leg-mounted accelerometers on 348 Holstein cows, 53 of them during two lactations. The cows were milked twice daily and had no access to pasture. During a lactation, locomotion score (LS) was assessed on average 2.4 times (s.d. 1.3). Based on daily lying duration, standing duration, walking duration, total number of steps, step frequency, motion index (MI, i.e. total acceleration) for lying, standing and walking, eight accelerometer means and their corresponding coefficient of variation (CV) were calculated for each week immediately before an LS. A principal component analysis was performed to evaluate the relationship between the variables. The effects of LS and farm on the principal components (PC) and on the variables were analysed in a mixed model. The first four PC accounted for 27%, 18%, 12% and 10% of the total variation, respectively. PC1 corresponded to Activity variability due to heavy loading by five CV variables related to standing and walking. PC2 corresponded to Activity level due to heavy loading by MI walking, MI standing and walking duration. PC3 corresponded to Recumbency due to heavy loading by four variables related to lying. PC4 corresponded mainly to Stepping due to heavy loading by step frequency. Activity variability at LS4 was significantly higher than at the lower LS levels. Activity level was significantly higher at LS1 than at LS2, which was significantly higher than at LS4. Recumbency was unaffected by LS. Stepping at LS1 and LS2 was significantly higher than at LS3 and LS4. Activity level was significantly lower on farm 3 compared with farms 1 and 2. Stepping was significantly lower on farms 1 and 3 compared with farms 2 and 4. MI standing indicated increased restlessness while standing when cows increased from LS3 to LS4. Lying duration was only increased in lame cows. In conclusion, Activity level differed already between LS1 and LS2, thus detecting early signs of lameness, particularly through contributions from walking duration and MI walking. Lameness detection models including walking duration, MI walking and MI standing seem worthy of further investigation.

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Depressed DHEA and increased sickness response behaviors in lame dairy cows with inflammatory foot lesions

Cited by 85 publications

References 62 publications

Dairy Cattle Welfare Status Measured by Animal-Linked Parameters Under Tunisian Rearing Conditions

Dairy Cattle Welfare Status Measured by Animal-Linked Parameters Under Tunisian Rearing Conditions

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Lameness detection via leg-mounted accelerometers on dairy cows on four commercial farms

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