Depressed children with asthma evidence increased airway resistance: “Vagal bias” as a mechanism?

Miller, Bruce D.; Wood, Beatrice L.; Lim, JungHa; Ballow, Mark; Hsu, ChiunYu

doi:10.1016/j.jaci.2009.04.038

Cited by 52 publications

(49 citation statements)

References 62 publications

(62 reference statements)

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“…Environmental factors, including pollutants, allergen exposure, psychological stress and weather conditions, may increase the risk of developing an acute asthma exacerbation in both children and adults [24][25][26][27][28][29][30]. The multiplicity of precipitating factors points towards a multifactorial cause, as well as potential interactions, which have been shown for some combinations of factors, such as pollutants [31,32].…”

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 99%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Xepapadaki¹,

Papadopoulos²

2010

European Respiratory Journal

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Respiratory infections have been implicated in the origin and exacerbation of asthma in a variety of ways; however, systemisation of this knowledge in a way helpful for disease management remains suboptimal.Several conceptual issues need to be taken into account: the fact that the effects of an infection may vary according to genetic background, the current immune status of the host, and parallel environmental stimuli, in addition to the particular infectious agent itself. Moreover, childhood is a very special period because of the continuous processes taking place, such as neural, immune and respiratory maturation.Epidemiological studies have convincingly demonstrated that the majority of asthma exacerbations, in both adults and children, follow viral upper respiratory tract infections. Asthma exacerbations are still often unresponsive to current asthma treatment, and new therapeutic approaches are required.This review presents current knowledge on the associations between infection and exacerbation of established asthma with respect to definitions, epidemiology, mechanisms and treatment.

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Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 99%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Xepapadaki¹,

Papadopoulos²

2010

European Respiratory Journal

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“…Another investigation related to the neuroimmune connection came from Miller et al, 80 who reported that children with depressive symptoms manifest vagal bias when emotionally stressed. Those with depressive symptoms and an FEV 1 of less than 80% of predicted value manifest greater airway resistance.…”

Section: Drug-response Modifiersmentioning

confidence: 99%

Advances in pediatric asthma in 2009: Gaining control of childhood asthma

Szefler

2010

Journal of Allergy and Clinical Immunology

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“…CAB has been studied once in a depression-relevant sample: Miller, Wood, Lim, Ballow & Hsu (2009) found that children with asthma who were high on depression symptoms showed greater increases in CAB in response to films depicting distressing scenes of loss, death, and dying (greater increases in PNS relative to SNS activity). In contrast, asthmatic children low on depressive symptoms showed the normative pattern of response to stress (greater decreases in CAB—greater increase in sympathetic relative to parasympathetic activity), which the authors indicated would be most adaptive for airway functioning in these patients.…”

mentioning

confidence: 99%

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

Bylsma

Yaroslavsky

Rottenberg

et al. 2015

Biological Psychology

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Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation (Berntson, Norman, Hawkley, & Cacioppo, 2008), and is believed to reflect overall autonomic flexibility in the face of environmental challenges. However, CAB has not been examined in depression. We examined changes in CAB and other physiological variables in 179 youth with a history of juvenile onset depression (JOD) and 161 healthy controls, in response to two psychological (unsolvable puzzle, sad film) and two physical (handgrip, and forehead cold pressor) challenges. In repeated measures analyses, controls showed expected reductions in CAB for both the handgrip and unsolvable puzzle, reflecting a shift to sympathetic relative to parasympathetic activation. By contrast, JOD youth showed increased CAB from baseline for both tasks (ps<.05). No effects were found for the forehead cold pressor or sad film tasks, suggesting that CAB differences may arise under conditions requiring greater attentional control or sustained effort.

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Depressed children with asthma evidence increased airway resistance: “Vagal bias” as a mechanism?

Cited by 52 publications

References 62 publications

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Advances in pediatric asthma in 2009: Gaining control of childhood asthma

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

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