Depressant Effect of Marihuana Smoke on Antibactericidal Activity of Pulmonary Alveolar Macrophages

Huber, Gary L.; Simmons, Geneva A.; McCarthy, C R; Cutting, Mary B.; Laguarda, Raul; Pereira, Wlademir

doi:10.1378/chest.68.6.769

Cited by 30 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies demonstrating that both ⌬ 9 -THS and marijuana smoke can reduce the antibacterial activity of AMs were performed solely with animal cells and animal models (12,(35)(36)(37). Our results are the first to demonstrate that these effects occur in the lungs of habitual smokers.…”

Section: Discussionsupporting

confidence: 47%

Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production

Baldwin

Tashkin

Buckley

et al. 1997

Am J Respir Crit Care Med

219

140

View full text Add to dashboard Cite

Use of marijuana and cocaine is on the rise in the United States. Although pulmonary toxicity from these drugs has occasionally been reported, little is known about their effects on the lung microenvironment. We evaluated the function of alveolar macrophages (AMs) recovered from the lungs of nonsmokers and habitual smokers of either tobacco, marijuana, or crack cocaine. AMs recovered from marijuana smokers were deficient in their ability to phagocytose Staphylococcus aureus (p < 0.01). AMs from marijuana smokers and from cocaine users were also severely limited in their ability to kill both bacteria and tumor cells (p < 0.01). Studies using NG-monomethyl-L-arginine monoacetate, an inhibitor of nitric oxide synthase, suggest that AMs from nonsmokers and tobacco smokers were able to use nitric oxide as an antibacterial effector molecule, while AMs from smokers of marijuana and cocaine were not. Finally, AMs from marijuana smokers, but not from smokers of tobacco or cocaine, produced less than normal amounts of tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, and interleukin-6 when stimulated in culture with lipopolysaccharide. In contrast, the production of transforming growth factor-beta, an immunosuppressive cytokine, was similar in all groups. These findings indicate that habitual exposure of the lung to either marijuana or cocaine impairs the function and/or cytokine production of AMs. The ultimate outcome of these effects may be an enhanced susceptibility to infectious disease, cancer, and AIDS.

show abstract

Section: Discussionsupporting

confidence: 47%

Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production

Baldwin

Tashkin

Buckley

et al. 1997

Am J Respir Crit Care Med

219

140

View full text Add to dashboard Cite

show abstract

“…Various functional defects of alveolar and peritoneal macrophages from humans, rats or mice following in vivo or in vitro exposure to marijuana or THC also have been reported. These alterations have included decreases in cell motility, ability to spread in vitro, release of β-glucuronidase, phagocytosis of yeast particles, and inactivation of Staphylococcus aureus and S. albus (Huber et al, 1975;Chari-Briton, 1976;McCarthy et al, 1976;Drath et al, 1979;Huber et al, 1978;Lopez-Cepero et al, 1986;Specter et al, 1991;Tang et al, 1992). In addition, THC has been reported to affect macrophage processing of soluble protein antigens (McCoy et al, 1995;.…”

Section: Introductionmentioning

confidence: 99%

The Cannabinoid Delta-9-tetrahydrocannabinol Mediates Inhibition of Macrophage Chemotaxis to RANTES/CCL5: Linkage to the CB2 Receptor

Raborn

Marciano‐Cabral

Buckley

et al. 2007

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

The chemotactic response of murine peritoneal macrophages to RANTES/CCL5 was inhibited significantly following pretreatment with delta-9-tetrahydrocannabinol (THC), the major psychoactive component in marijuana. Significant inhibition of this chemokine directed migratory response was obtained also when the full cannabinoid agonist CP55940 was used. The CB 2 receptorselective ligand O-2137 exerted a robust inhibition of chemotaxis while the CB 1 receptor-selective ligand ACEA had a minimal effect. The THC-mediated inhibition was reversed by the CB 2 receptorspecific antagonist SR144528 but not by the CB 1 receptor-specific antagonist SR141716A. In addition, THC treatment had a minimal effect on the chemotactic response of peritoneal macrophages from CB 2 knockout mice. Collectively, these results suggest that cannabinoids act through the CB 2 receptor to trans-deactivate migratory responsiveness to RANTES/CCL5. Furthermore, the results suggest that the CB 2 receptor may be a constituent element of a network of G protein-coupled receptor signal transductional systems, inclusive of chemokine receptors, that act coordinately to modulate macrophage migration.

show abstract

“…In fact a lower T-cell count, a reduced lymphocyte response to phytohaemaglutinine (PHA), a reduced phagocytic activity of the polymorphonuclear leukocytes (Petersen etal., 1975;Nahas et al, 1975) and a marked reduction in T-cells rosette formation has been observed (Cushman et al, 1975;Cushman and Khurana, 1976). Moreover a dose dependent bactericidal activity decrease among pulmonary macrophages previously exposed to marijuana smoke was found (Huber et al, 1975). On the contrary, other studies did not confirm these effects (White et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

Marijuana smoking as a possible cause of tongue carcinoma in young patients

Almadori

Paludetti²,

Cerullo³

et al. 1990

J. Laryngol. Otol.

View full text Add to dashboard Cite

A case of T1N0M0 carcinoma of the tongue in a male 23-year-old 'regular' marijuana smoker is described. Hemiglossectomy and complete bilateral neck dissection were carried out. No post-operative radiotherapy was given as the resection margins were histologically negative. The tumour recurred one year later in the left cervical region involving the mandible and surgery was again performed, but after three months, neck disease was still evident. The case described case implies the introduction of marijuana as a possible new risk factor in the development of oral cavity tumours. Resection of the primary lesion has to be as wide as possible even in T1 cases, due to the aggressive biological behaviour of such tumours in young subjects.

show abstract

Depressant Effect of Marihuana Smoke on Antibactericidal Activity of Pulmonary Alveolar Macrophages

Cited by 30 publications

References 12 publications

Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production

Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production

The Cannabinoid Delta-9-tetrahydrocannabinol Mediates Inhibition of Macrophage Chemotaxis to RANTES/CCL5: Linkage to the CB2 Receptor

Marijuana smoking as a possible cause of tongue carcinoma in young patients

Contact Info

Product

Resources

About