2015
DOI: 10.5604/00306657.1184545
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Depozycja donosowych preparatów glikokortykosteroidów – badania wstępne

Abstract: The practical application of tridimensional representation (3D printout) of actual geometry of nasal cavity to establish the deposition of inGKS was proven. Droplet size and the geometry of the aerosol cloud introduced into the nostril determine the significant deposition of medication droplets in the anterior part of the nasal cavity. Both physical properties of the drug as well as spraying system applied influence spatial distribution of the drug. The interaction of the air flow with the layer of deposited f… Show more

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Cited by 4 publications
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“…Laser aerosol spectrometry was used to study the droplet sizes and distributions in the nasal cavity after use of NCS sprays. Droplet storage was detected in a larger mucosal area with fluticasone furoate containing nasal preparations compared to the ones containing fluticasone propionate and mometasone furoate ( 485 ). Triamcinolone acetonide and flunisolide bind to plasma proteins less, and pass into the systemic circulation in smaller amounts.…”
Section: Treatment Of Allergic Rhinitismentioning
confidence: 99%
“…Laser aerosol spectrometry was used to study the droplet sizes and distributions in the nasal cavity after use of NCS sprays. Droplet storage was detected in a larger mucosal area with fluticasone furoate containing nasal preparations compared to the ones containing fluticasone propionate and mometasone furoate ( 485 ). Triamcinolone acetonide and flunisolide bind to plasma proteins less, and pass into the systemic circulation in smaller amounts.…”
Section: Treatment Of Allergic Rhinitismentioning
confidence: 99%