Depot unilamellar liposomes to sustain transscleral drug Co-delivery for ophthalmic infection therapy

Microfluidics-based PLGA nanoparticles of ratiometric multidrug: From encapsulation and release rates to cytotoxicity in human lens epithelial cells

“…Nanomedicines that co-encapsulate multiple drugs are increasingly recognized as useful medications for managing cancers and chronic diseases [ 1 , 2 ]. Examples of nanomedicine that have demonstrated ratiometric co-encapsulation of drug combination include liposomes, such as CPX-351, the antineoplastic liposomal drugs combination (cytarabine and daunorubicin) at the fixed ratio, polymer-based nanocarrier, micelles (e.g., Triolimus) and polymer-lipid hybrid nanoparticles [ [3] , [4] , [5] , [6] , [7] , [8] , [9] ]. Compared to other dosage forms (e.g., microparticles, hydrogel), multidrug nanomedicines can undergo cellular uptake as a unit cargo to enable subcellular drug delivery at a fixed ratio, thereby producing synergistic therapeutic efficacy.…”

A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions

“…This customization considers the drug’s properties and the microenvironment of the target ocular tissue. The key features are briefly summarized in Table 2 [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

“…Nanosuspensions and nanoemulsions, used for delivering poorly soluble and permeable drugs, have shown effectiveness. Nanoemulsions boost drug solubility, while nanosuspensions, stabilized by various polymers, are ideal for high-molecular-weight drugs [ 35 , 36 , 37 , 38 ]. Finally, microneedles, a newer technique, offer improved accuracy, self-administration, and fewer complications from injections [ 39 ].…”

“…This will provide the necessary foundation for the use of nanosponges as a supplementary treatment for bacterial intraocular infections [34]. While nanosponges showcase promising data, unilamellar liposomes have also recently been investigated for periocular transscleral co-delivery of steroids and antibiotics, offering potential new possibilities for treating chronic ophthalmic infections [35].…”