Depot Medroxyprogesterone
in the Management of Benign
Prostatic Hyperplasia

Onu, Pedro E.

doi:10.1159/000475056

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Previous proof of concept and safety of hormonal treatment for prostatic obstruction was presented for patients with prostate cancer and AUR [13, 14] and also short-term hormonal treatment for prostatic obstruction in a noncancer scenario [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

“…Even examining patients without cancer diagnosis, Narayan et al described that flutamide reduced the prostate volume in a dose-related fashion and resulted in an increase in peak flow rate at 4 weeks (250 mg three times daily, P value < 0.05) [15] and Onu showed the effects of depot medroxyprogesterone 150 mg single-dose intramuscular injection in a similar fashion, as a safe and effective treatment for prostatic obstruction where potency is a secondary consideration [16]. …”

Section: Discussionmentioning

confidence: 99%

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Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study

Reis

Mendonça

Carneiro

et al. 2014

Advances in Urology

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Patients who failed a catheter-free trial after acute urinary retention and one week of full dose alpha-blocker and 5-alpha-reductase inhibitor were offered Diethylstilbestrol 1 mg plus Aspirin 100 mg over 4 weeks. Prostate volume, age, serum creatinine, and initial retention drained urine volume were recorded. After excluding cardiovascular morbidity (n = 7), upper urinary tract dilation (n = 3), compromised renal function (n = 2), urinary tract infection (n = 2), neurological diagnosis (n = 2), or preferred immediate channel transurethral resection of prostate (n = 5), 48 of 69 consecutive patients ≥70 years were included. Mean age was 76.6 years (70–84), mean prostate volume 90 cm3 (42–128), and mean follow-up 204 days; 58% (28/48) were passing urine and 42% (20/48) were catheter dependent after 4 weeks Diethylstilbestrol trial. Mean age and drained urine volume of catheter dependent patients were 82.4 years and 850 mL compared with 74.6 years and 530 mL in catheter-free men, respectively. Age and drained urine volume were independent predictors of catheter-free trial (both P < 0.01). Seventy-five percent (6/8) of patients 80 years and older were catheter dependent. Transient nipple/breast tenderness and gynecomastia were the only adverse effects reported by 21% (10/48) and 4% (2/48), respectively. No patient presented severe complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study

Reis

Mendonça

Carneiro

et al. 2014

Advances in Urology

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“…Serum MPA concentrations are generally maintained at a plateau for about 3 months, after which there is a gradual decline. Although a literature search has not revealed any publication regarding the pharmacokinetics of DMPA in men, the results of one clinical study implied that a single injection of DMPA at a dose of 150 mg has a long duration of effect (3 months) on patients with benign prostatic hyperplasia (33). Another clinical trial evaluating 800 mg of a fused crystalline T implant in combination with a single injection of 300 mg DMPA for application as a male contraceptive demonstrated that the combined regimen could significantly suppress gonadotropin levels and spermatogenesis for 3 months without serious side effects (12).…”

Section: Discussionmentioning

confidence: 99%

Male Hormonal Contraception: Effects of Injections of Testosterone Undecanoate and Depot Medroxyprogesterone Acetate at Eight-Week Intervals in Chinese Men

Tong

et al. 2004

The Journal of Clinical Endocrinology &Amp; Metabolism

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Surveys indicate that one form of acceptable male hormonal contraception would consist of injections given at 2- to 3-month intervals. This report describes a study of depot medroxyprogesterone acetate (DMPA) and testosterone undecanoate (TU) injected at 8-wk intervals for suppression of spermatogenesis in healthy Chinese men. After screening, 30 healthy volunteers were enrolled and randomly assigned to one of three dose groups (n = 10/group): 1000 mg TU (group A); 1000 mg TU plus 150 mg DMPA (group B); 1000 mg TU plus 300 mg DMPA (group C). All doses were given as im injections at 8-wk intervals. The study consisted of an 8-wk control (baseline) period, a 24-wk treatment period, and a 24-wk recovery period. Consistent azoospermia or severe oligozoospermia was achieved and maintained in all volunteers during the treatment period, except for two men in the TU-alone group who experienced a rebound in sperm concentrations. An 8-wk regimen of TU plus DMPA at both tested combination doses effectively suppressed spermatogenesis to azoospermia in Chinese men. All volunteers tolerated the injections; no serious adverse effects were reported. The lower-dose combination is recommended for further testing in an expanded clinical trial or contraceptive efficacy study.

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“…В одном из немногих двойных слепых плацебоконтролируемых исследований эффективности синтетических прогестинов при ДГПЖ 80 пациентам с данной патологией однократно внутримышечно вводили 150 мг пролонгированного прогестина депо медроксипрогестерона ацетата (ДМПА) (депо-провера) или плацебо [49]. Концентрация сывороточного тестостерона достигла кастрационного уровня уже в течение 3 дней после инъекции препарата при отсутствии изменений в группе плацебо.…”

Section: возможности клинического применения препаратов прогестерона ...unclassified

“…Однако практически у всех мужчин предстательная железа претерпевала обратные изменения в сторону увеличения в течение 18-36 нед после инъекции. Несмотря на то что ДМПА хорошо переносился, у мужчин после его инъекции отмечалась более высокая частота эректильной дисфункции, снижения либидо и нарушений эякуляции, связанных с временной супрессией синтеза тестостерона и эстрогенов, в отличие от группы плацебо-контроля [49].…”

Section: обзорная статья / Reviewunclassified

Progesterone and prostate: a history of scientific study and the modern view of the problem

Греков

Tyuzikov

Смирнов

2023

Androl. genit. hir.

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From the moment of discovery until recently, scientific and practical interest in progesterone has been focused exclusively on female reproductive endocrinology and obstetrics and gynecology. At the same time, the potential role of progesterone in the male endocrine, reproductive and genitourinary systems from the standpoint of the historically established interpretation of this sex steroid hormone only as a female steroid with predominantly reproductive and antiproliferative effects has remained in the shadow of research for many decades. However, over the past two decades, interesting data has begun to accumulate that progesterone is just as important for men as for women. Moreover, in both sexes progesterone performs not only classical (reproductive) effects, but also has a wide range of so-called non-classical (non-productive) effects, which make it possible to call it a kind of “gray cardinal” of steroidogenesis. In the review article, based on the available literature, general and particular issues of endocrinology of progesterone in the male body are considered. The questions of the physiological role of progesterone in maintaining the hormonal and metabolic status of the prostate gland and the mechanisms of its participation in the pathogenesis of various prostate diseases are covered in more detail.

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Depot Medroxyprogesterone in the Management of Benign Prostatic Hyperplasia

Cited by 8 publications

References 29 publications

Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study

Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study

Male Hormonal Contraception: Effects of Injections of Testosterone Undecanoate and Depot Medroxyprogesterone Acetate at Eight-Week Intervals in Chinese Men

Progesterone and prostate: a history of scientific study and the modern view of the problem

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