Deposition of 0.1 μm chain aggregate aerosols in beagle dogs

Wolff, Ronald K.; Kanapilly, G.M.; DeNee, Phillip B.; McClellan, R.O.

doi:10.1016/0021-8502(81)90044-6

Cited by 46 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results seem to be di erent from the published experimental tests on human and animal [26][27][28], in which smaller overall deposition fraction (lower than 30%) has been measured for both total lung and alveolar region. The overall deposition fraction is dened as the amount of particles captured in the alveolar region compared to the amount of particles entering through the mouth or nose.…”

Section: Discussion and Limitationscontrasting

confidence: 55%

Submicron particle deposition in pulmonary alveoli during cyclic breathing

2017

View full text Add to dashboard Cite

Abstract. The prediction of deposition e ciency of submicron particles in the pulmonary alveoli has received special attention due to its importance for drug delivery systems and for assessing air pollutants health risks. In this work, the pulmonary alveoli of a healthy human are idealized by a three-dimensional honeycomb-like con guration and a uid-structure interaction analysis is performed. In contrast to previous works in which the inlet ow rate is prede ned, in this model, a negative pressure is imposed on the outside surface of the alveolus which causes air to ow in and out of the alveolus. The resulting ow patterns con rmed that there was no circulation in the terminal alveolus. The predicted alveolar air ow was used to calculate the trajectories of submicron particles using the Lagrangian approach. Our ndings suggest that an accurate simulation requires including at least ten breathing cycles, considering a parabolic radial distribution of injected particles and continuous injection. The presented results show high deposition e ciency for submicron sizes in the alveolar region if these particles can reach the alveolar region. Therefore, the vesicles technology in which particle agglomerates would be released after the vesicle reaching the alveoli is suggested for targeted drug delivery to the alveolar region.

show abstract

Section: Discussion and Limitationscontrasting

confidence: 55%

Submicron particle deposition in pulmonary alveoli during cyclic breathing

2017

View full text Add to dashboard Cite

show abstract

“…The majority of particles deposited to the terminal bronchioles measure less than 10 ¿tm in diameter. Larger particles are effectively removed by the conducting airway (Melandri et al, 1975;Thorne et al, 1985;Wolff et al, 1981).…”

Section: Influence Of Sample Size and Preparation On Toxicitymentioning

confidence: 98%

“…to fibrogenesis are still poorly understood. The biological characteristics of the dusts are largely unknown, although it is suggested that the dust size, shape, surface charge, roughness, surface chemical composition, trace metal content, and crystallinity; dose of silica in the ambient air of the workplace; duration of exposure; genetic variation in exposed subjects; personal respiratory patterns; and presence of any coexisting disease (such as tuberculosis or rheumatoid arthritis) all influence the expression of silicosis (Koskinen et al, 1983;Noweir et al, 1980;Raask and Schilling, 1980;Reiser and Last, 1979;Thorne et al, 1985;Wolff et al, 1981). The actual biochemical mechanisms through which these factors operate are still unclear.…”

Section: Introductionmentioning

confidence: 98%

The chemical properties of silica particle surface in relation to silica‐cell interactions

Hu³

et al. 1989

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Although silicosis has been studied extensively, the mechanism is still not fully understood. Experiments do provide evidence that the actions of unique properties of silica surface on the cell membrane are the starting point of silicotic processes. This paper summarizes literature on chemical properties of silica surface, and the effect of particle size on silica toxicity. This paper also discusses the ways in which silica dusts are thought to interact with the cell membrane, with emphasis on freshness, hydrogen bonding, and free-radical interactions.

show abstract

“…The induced diseases observed in laboratory animals may not always have direct counterparts in man, and vice versa. This is illustrated by our inability to yet (98). These are considered to be good estimates for man until such time as similar data can be obtained in people.…”

Section: Recommendationsmentioning

confidence: 97%

Consensus report: mutagenicity and carcinogenicity of car exhausts and coal combustion emissions

1983

Environ Health Perspect

View full text Add to dashboard Cite

Deposition of 0.1 μm chain aggregate aerosols in beagle dogs

Cited by 46 publications

References 17 publications

Submicron particle deposition in pulmonary alveoli during cyclic breathing

Submicron particle deposition in pulmonary alveoli during cyclic breathing

The chemical properties of silica particle surface in relation to silica‐cell interactions

Consensus report: mutagenicity and carcinogenicity of car exhausts and coal combustion emissions

Contact Info

Product

Resources

About