Deposition fraction of ellipsoidal fibers in a model of human nasal cavity for laminar and turbulent flows

Tavakol, Mohammad Mehdi; Ghahramani, Ebrahim; Abouali, Omid; Yaghoubi, M.; Ahmadi, Goodarz

doi:10.1016/j.jaerosci.2017.07.008

Cited by 21 publications

(11 citation statements)

References 42 publications

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“…(12)-(15). For fibers of diameter 2-20 μm, and aspect ratio from 2 to 80, the findings of Tavakol et al (2017) are reproduced in Fig. 5.…”

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 69%

“…Extending the work of Dastan et al (2014), Tavakol et al (2017) investigated the ellipsoidal fiber transport and deposition under turbulent flow regime (with Q > 12 L/min) Fig. 4 (a) Fiber total deposition fraction against fiber semi-minor axis in two human nasal cavities at breathing rate Q = 7.5 L/min; (b) deposition fraction of unit density fibrous particles of diameter 2-30 μm and aspect ratio β from 1 to 80 versus impaction parameter (IP); (c) comparison of total fiber deposition fraction versus Stokes-based impaction parameter (SIP) with the spherical deposition fraction of earlier work (2 μm < d < 30 μm, 1 < β < 80); (d) comparison of total fiber deposition fraction versus pressure-based impaction parameter (PIP) with the spherical deposition fraction of earlier work (2 μm < d < 30 μm, 1 < β < 80) (Dastan et al, 2014;reproduced with permission © Elsevier Ltd. 2013). in a single nasal cavity (Cast B).…”

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 99%

“…5 (a) Comparison of fiber total deposition fraction against impaction parameter IP by using ANSYS-FLUENT DRW and modified CRW mode through ANSYS-FLUENT-UDF; (b) comparison of fiber total deposition fraction against impaction parameter IP with and without turbulence fluctuations; (c) comparison of fiber total deposition fraction against impaction parameter IP with and without turbulence rotational diffusion; (d) comparison of the total deposition fraction of fibers and equivalent Stokes spheres (Eq. (68)) versus the impaction parameter IP (Tavakol et al, 2017;reproduced with permission © Elsevier Ltd. 2017). inertial parameter and impaction parameters (IP) in Figs. 6(a) and 6(b) have the same formulation.…”

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 99%

“…Using the E-L approach, Tavakol et al (2017) extended the formulation of the governing equations to cover noncreeping hydrodynamic forces and torques for ellipsoidal inertial particles. Njobuenwu and Fairweather (2014 investigated the effect of shape on inertial particle dynamics in a channel flow for spherical, needle, and platelet-like particles using the large eddy simulations.…”

Section: Introductionmentioning

confidence: 99%

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Computational modeling of fiber transport in human respiratory airways—A review

Tian

Ahmadi

2020

Exp. Comput. Multiph. Flow

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Investigations on the respiratory transport and deposition of airborne asbestos, man-made vitreous fibers (MMVFs), and carbon nanofiber/carbon nanotubes have been actively conducted in the past few decades. The elongated particles' distinctive needle-like geometry has been identified as the main cause of extreme carcinogenicity when compared to inhaled spherical particles. Consequently, uncovering the intrinsic relationship between the particle's unique elongated shape and its transport characteristics in human respiratory systems is crucial for understanding fiber inhalation toxicity. Currently, such information can only be provided by computational modeling. This review summarized the current state of the art of computational modeling of fiber transport in the human respiratory tract. The needed future researches were also discussed. Keywords non-spherical particle asbestos fiber computational modeling transport and deposition tracheobronchial tree nasal cavity respiratory airways Article History

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“…(12)-(15). For fibers of diameter 2-20 μm, and aspect ratio from 2 to 80, the findings of Tavakol et al (2017) are reproduced in Fig. 5.…”

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 69%

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 99%

Section: Applications In Human Nasal Cavitiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Computational modeling of fiber transport in human respiratory airways—A review

Tian

Ahmadi

2020

Exp. Comput. Multiph. Flow

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show abstract

“…[40,41] and experimental models [42][43][44] have been considered to analyse the airflow pattern in the extrathoracic region. A commonly used model for airflow characterization in the extrathoracic airways are either non-realistic idealized model [23,[45][46][47] or realistic CT-based models [15,23,39,[48][49][50][51]. Some of the published literature considered laminar flow in this region [40,52,53] whereas, most of the studies are based on turbulent flow [42,45,46,54].…”

Section: Extrathoracic Regionmentioning

confidence: 99%

A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition

Islam

Paul

Ong

et al. 2020

IJERPH

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The understanding of complex inhalation and transport processes of pollutant particles through the human respiratory system is important for investigations into dosimetry and respiratory health effects in various settings, such as environmental or occupational health. The studies over the last few decades for micro- and nanoparticle transport and deposition have advanced the understanding of drug-aerosol impacts in the mouth-throat and the upper airways. However, most of the Lagrangian and Eulerian studies have utilized the non-realistic symmetric anatomical model for airflow and particle deposition predictions. Recent improvements to visualization techniques using high-resolution computed tomography (CT) data and the resultant development of three dimensional (3-D) anatomical models support the realistic representation of lung geometry. Yet, the selection of different modelling approaches to analyze the transitional flow behavior and the use of different inlet and outlet conditions provide a dissimilar prediction of particle deposition in the human lung. Moreover, incorporation of relevant physical and appropriate boundary conditions are important factors to consider for the more accurate prediction of transitional flow and particle transport in human lung. This review critically appraises currently available literature on airflow and particle transport mechanism in the lungs, as well as numerical simulations with the aim to explore processes involved. Numerical studies found that both the Euler–Lagrange (E-L) and Euler–Euler methods do not influence nanoparticle (particle diameter ≤50 nm) deposition patterns at a flow rate ≤25 L/min. Furthermore, numerical studies demonstrated that turbulence dispersion does not significantly affect nanoparticle deposition patterns. This critical review aims to develop the field and increase the state-of-the-art in human lung modelling.

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Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

Khoa

Phuong

Takahashi

et al. 2022

Japan Architectural Review

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Particles longer than 5 μm and with a length/diameter ratio >3 are defined as fibers. Asbestos or other fibers are still identified in residential environments due to the emission from asbestos-used building materials. The respiratory system is the primary route of asbestos exposure; under a longer residence time, asbestosrelated adverse health effects are inevitable. Currently, asbestos fibers have been replaced with man-made vitreous fibers (MMVFs); however, studies have revealed some similar biological effects of MMVFs with asbestos. Therefore, MMVFs-induced diseases need to be determined by analyzing their deposition characteristics and foci in human respiratory tracts. In this study, we used computational fluid dynamics method to investigate fibers' airflow and deposition patterns in two realistic human respiratory models. Two drag models were used to predict the deposition of uniform 1 μm (asbestos) and 3.66 μm (carbon fiber-CF) diameter, 15-300 μm long fibers. Two drag models provided comparable results with the experimental data. Comparatively, asbestos deposition was independent of fiber length, while CF deposition increased proportionally to fiber length. The highest level of local deposition was detected in the anterior nasal cavity. The results obtained from this study can extend current knowledge of human vitreous fiber exposure-related lung diseases. Keywords asbestos, computational fluid dynamics, drag force, human respiratory system, man-made vitreous fiber (MMVF)-like carbon fiberThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Deposition fraction of ellipsoidal fibers in a model of human nasal cavity for laminar and turbulent flows

Cited by 21 publications

References 42 publications

Computational modeling of fiber transport in human respiratory airways—A review

Computational modeling of fiber transport in human respiratory airways—A review

A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition

Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

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