Depolymerized non-digestible sulfated algal polysaccharides produced by hydrothermal treatment with enhanced bacterial fermentation characteristics

Xiong, Lixia; Peng, Bo; Cheung, Peter C.K.; Wang, Jiacheng; Zheng, Xudong; You, Lijun

doi:10.1016/j.foodhyd.2022.107687

Cited by 16 publications

(3 citation statements)

References 39 publications

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“…The molecular weight distribution of polysaccharide samples was determined by high‐performance gel permeation chromatography coupled with a TSK‐GEL G‐6000 PWXL column (7.8 mm × 300 mm i.d., 13 μm, Tosoh Co., Tokyo, Japan) and TSK‐GRL 3000 PWXL column (7.8 mm × 300 mm i.d., 7 μm, Tosoh Co.). The column temperature was set at 35°C, and the mobile phase was 0.02 mol/L KH 2 PO 4 solution with a flow rate of 0.5 mL/min (Li et al., 2022).…”

Section: Methodsmentioning

confidence: 99%

The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme

et al. 2023

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An alginate (named P1) prepared from Sargassum fusiforme has been proven to have significant anti‐photoaging activity in our previous study. In this study, alginate lyase was used to obtain P1 hydrolysates with different molecular weights, and their structural characteristics and anti‐photoaging activity were compared. Results showed that alginate lyases could rapidly degrade the molecular weight of P1 and slightly changed its chemical composition. Fourier transform infrared spectra indicated that alginate lyase treatment did not change the main functional groups of P1. Moreover, the inhibitory effects of P1 on MMPs (MMP‐1, MMP‐3 and MMP‐9) and reactive oxygen species were also improved after hydrolyzed with alginate lyase, especially sample A‐30 (hydrolysis for 30 min). Methylation and nuclear magnetic resonance results indicated that the main chain of A‐30 was →4)‐β‐ManA‐(1→4)‐α‐GulA‐(1→4)‐β‐ManA‐(1→4)‐β‐ManA‐(1→4)‐α‐GulA‐(1→4)‐β‐ManA‐(1→3, 4)‐β‐ManA‐(1→, with the end group of α‐Fucp‐(1→ attached to the O‐3 position of →3, 4)‐β‐ManA‐(1→ on the side chain. It indicated that alginate lyase did not change the backbone of P1 but decreased the molecular or degree of polymerization at 30 min of hydrolysis. This is the first report on the anti‐photoaging activity of alginate hydrolysates. The results will provide effective theoretical support for improving the utilization and promoting the application of S. fusiforme.

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Section: Methodsmentioning

confidence: 99%

The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme

et al. 2023

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“…Then the crucial metabolic change of BSP takes place in the colon. In the distal intestine, unabsorbed BSP will be metabolized and utilized by gut microbiota (Li et al., 2022). And the microbial transformation products of BSP exert considerable effects on gut microbiota, which promote the host's health.…”

Section: Absorption Of Bsp In the Intestinementioning

confidence: 99%

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

et al. 2023

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The intestinal barrier is critical in maintaining gut homeostasis and host health. The intestinal barrier dysfunction contributes to intestinal and systemic diseases like inflammatory bowel disease, colorectal cancer, and metabolic syndromes. This review summarizes the physicochemical properties of three main kinds of brown seaweed polysaccharides (BSP), laminarin, fucoidan, and alginate, along with their absorption and metabolism in the intestine and their effects on the intestinal barrier. The physicochemical properties of BSP were closely related to their beneficial effects on intestinal health. BSP were not digested directly in the upper gastrointestinal tract but could be utilized through fermentation by the gut microbiota. BSP kept the integrity of intestinal epithelium by ameliorating intestinal oxidative stress through the nuclear factor erythroid 2‐related factor 2 signaling pathway. They also reduced tight junction dysfunction and intestinal permeability and increased the expression of mucins. Moreover, BSP regulated the composition and abundance of gut microbiota and promoted the production of beneficial metabolites such as short‐chain fatty acids. This review will help to understand the gut health‐promoting functions of the natural compounds derived from brown seaweed and offer a new perspective on intestinal disease prevention and therapy with high effectiveness and safety.

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“…They exhibited lower apparent viscosity and enhanced prebiotic activities. The depolymerized sulfated polysaccharides (<5 kDa) exhibited the best probiotic activities (Li et al, 2022).…”

Section: Probiotic Activitymentioning

confidence: 99%

Research progress in the preparation, structural characterization, bioactivities, and potential applications of sulfated agarans from the genus Gracilaria

Liu

2022

Journal of Food Biochemistry

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The genus Gracilaria produces 80% of the world's industrial agar. Agar of this genus is a promising biologically active polymer, which has been used in the human diet and folk medicine, alternative for weight loss, treatment of diarrhea, etc. With more attention paid to the genus Gracilaria‐sulfated agarans (GSAs), they exhibited multitudinous health benefits in antioxidant, antiviral, antibacterial, prebiotics, anti‐tumor, anticoagulant, and antidiabetic. Various preparation procedures of GSAs making the diversities of structure and biological activity. Therefore, this review summarized the isolation, identification, bioactivity potentials, and applications of GSAs, providing a reference to the development of GSAs in functional food and pharmaceutical industry. Practical applications The genus Gracilaria is known as a raw material for agar extraction. GSAs are food‐grade agaran with the properties of thermoreversible gels at low concentrations, which are commonly used as an additive for making candies as well as raw material for making soup and snacks. They are used in folk medicine to treat diarrhea and other diseases. As an important bioactive macromolecule, GSAs have various biological activities (such as antioxidant, antiviral, antibacterial, probiotic, anti‐tumor, anticoagulant, and antidiabetic activities), and have the potential to be developed as functional food and medicine. They could also be used to create innovative agar‐based products such as antibacterial films and drug carriers.

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Depolymerized non-digestible sulfated algal polysaccharides produced by hydrothermal treatment with enhanced bacterial fermentation characteristics

Cited by 16 publications

References 39 publications

The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme

The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

Research progress in the preparation, structural characterization, bioactivities, and potential applications of sulfated agarans from the genus Gracilaria

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