“…Uptake of K + occurs concomitantly with uptake of Cl − and water, producing transient astrocyte swelling (Bellot-Saez, Kékesi, Morley, & Buskila, 2017). Based on its expression in astrocytic glia, the ClC-2 channel has been proposed as one of the channels that might participate in this Cl − uptake (Blanz et al, 2007;Hoegg-Beiler et al, 2014;Sirisi et al, 2017). Mutations in CLCN2, which codes for ClC-2, are responsible for leukoencephalopathy with ataxia (LKPAT) (Depienne et al, 2013) and ClC-2 has been related to megalencephalic leukoencephalopathy with subcortical cysts (MLC) (Hoegg-Beiler et al, 2014;Jeworutzki et al, 2012;Sirisi et al, 2017).…”