Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain

Samsam, Mohtashem; Coveñas, Rafael; Csillik, B.; Ahangari, Raheleh; Yajeya, Javier; Riquelme, Raúl; Narváez, José Ángel; Tramu, G.

doi:10.1016/s0891-0618(01)00088-6

Cited by 41 publications

(36 citation statements)

References 32 publications

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“…Pain SP and NK-1 receptors are present in the dorsal horn of the spinal cord and in nociception spinal SP and neurokinin A play an important role (Samsam et al 2001). Nerve fibers also transmit afferent signals to the CNS in response to inflammation (SP contributes to pain transmission in the CNS in inflammatory processes) (Samsam et al 2001).…”

Section: Alcohol Addictionmentioning

confidence: 99%

Involvement of substance P and the NK-1 receptor in human pathology

2014

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The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also present in cells not belonging to the nervous system (immune cells, liver, lung, placenta, etc.). SP is located in all body fluids, such as blood, cerebrospinal fluid, breast milk, etc. i.e. it is ubiquitous in human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. SP has been also implicated in pain, inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infection (e.g., HIV infection) and it plays an important role in cancer (e.g., tumor cell proliferation, antiapoptotic effects in tumor cells, angiogenesis, migration of tumor cells for invasion, infiltration and metastasis). This means that the SP/NK-1 receptor system is involved in the molecular bases of many human pathologies. Thus, knowledge of this system is the key for a better understanding and hence a better management of many human diseases. In this review, we update the involvement of the SP/NK-1 receptor system in the physiopathology of the above-mentioned pathologies and we suggest valuable future therapeutic interventions involving the use of NK-1 receptor antagonists, particularly in the treatment of emesis, depression, cancer, neural degeneration, inflammatory bowel disease, viral infection and pruritus, in which that system is upregulated.

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Section: Alcohol Addictionmentioning

confidence: 99%

Involvement of substance P and the NK-1 receptor in human pathology

2014

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“…It is believed that activation of TGVS during the head pain phase initiates a chemical cascade of vasoactive neuropeptides such as substance P, calcitonin gene-related peptide, neurokinin A, and nitric oxide. These molecules cause vasodilatation, which can contribute to headaches [17]. The TGVS transmitting migraine pain may be controlled by serotonergic neurons.…”

Section: Serotonin and Its Metabolites In Migrainementioning

confidence: 99%

Serotonin in Neurological Diseases

Dorszewska¹,

Florczak-Wyspiańska²,

Kowalska³

et al. 2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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Serotonin (5-HT) is responsible for anxiety, aggression, and stress. Alterations in a serotonergic system play a significant role in pathogenesis of neurological diseases and neuropsychiatric disorders. A wide range of disturbances associated with serotonergic neurotransmission results from different functions of 5-HT in a nervous system. It is believed that 5-HT may be involved in the pathogenesis of migraine, epilepsy, Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). In these diseases, disturbances of 5-HT and its metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), were observed in the plasma, blood platelets, and cerebrospinal fluid (CSF). Changes in the level of this biogenic amine (5-HT) may be associated with malfunction of 5-HT receptors, reuptake transporter for 5-HT (5-HTT, SERT), the enzymes responsible for the synthesis and metabolism of 5-HT, and genetic variants for serotonergic system. It seems that 5-HT and its metabolites may be used as a diagnostic and prognostic marker for neurological diseases or a target for more efficient therapy in neurology in the future.

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“…The activation of the primary nociceptive trigeminal afferents leads to peripheral neuropeptide release, calcitonin gene-related peptide (CGRP), neurokinin A and substance P are liberated to the perineural space [71,72], leading to vasodilatation and plasma protein extravasation and to the activation of mast cells and leukocytes collectively termed as neurogenic inflammation [73]. These phenomena are well characterized in animals, however in humans only little direct evidence supports the actual presence of neurogenic inflammation during the attack [74].…”

Section: Headache Phase and Postdromementioning

confidence: 99%

Tryptophan Catabolites and Migraine

Bohár

Párdutz

Vécsei

2016

CPD

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Abstract:Migraine is a highly disabling neurological condition affecting around 15% of the population worldwide.Decades of intensive research shed some light on diseases pathomechanism, but information is still missing about the initiation of the attack. In the past century, serotonin emerged as the main target of both basic and therapeutic research. As a result, the triptans, the only approved migraine specific drugs were developed. The involvement of glutamatergic mechanism in migraine headache development such as cortical hyperexcitability, and cortical spreading depression as the pathological correlate of migraine aura called the attention to the kynurenine pathway in migraine pathomechanism. The serotonin and kynurenine pathways are closely connected, as they both are the metabolic routes of the amino acid tryptophan. Kynurenine catabolites are important participants in glutamatergic neurotransmission, regulation also nociceptive processing of the trigeminal system. The current work attempts to collect recent data on both serotonin and kynurenine research related to migraine and emphasizes the importance of further research on this topic.

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Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain

Cited by 41 publications

References 32 publications

Involvement of substance P and the NK-1 receptor in human pathology

Involvement of substance P and the NK-1 receptor in human pathology

Serotonin in Neurological Diseases

Tryptophan Catabolites and Migraine

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