2020
DOI: 10.1089/neu.2019.6460
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Depletion of Microglia Attenuates Dendritic Spine Loss and Neuronal Apoptosis in the Acute Stage of Moderate Traumatic Brain Injury in Mice

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Cited by 36 publications
(26 citation statements)
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“…43,44,48,49 Increasing evidence show that microglia polarize into a variety of phenotypes at different stages of injuries in CNS. 50,51 Decreased expression of Arg1 in STAT6 −/− microglia/macrophages led to impairments in phagocytosis and loss of anti-inflammatory modality which indicates that microglia phenotype is closely related to phagocytosis. 52 Direct evidence for the relationship between specific microglia phenotype and phagocytosis should be investigated in the future.…”
Section: Fifth Mrs2578 Treatment Exacerbated the Results Of Mnss Andmentioning
confidence: 99%
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“…43,44,48,49 Increasing evidence show that microglia polarize into a variety of phenotypes at different stages of injuries in CNS. 50,51 Decreased expression of Arg1 in STAT6 −/− microglia/macrophages led to impairments in phagocytosis and loss of anti-inflammatory modality which indicates that microglia phenotype is closely related to phagocytosis. 52 Direct evidence for the relationship between specific microglia phenotype and phagocytosis should be investigated in the future.…”
Section: Fifth Mrs2578 Treatment Exacerbated the Results Of Mnss Andmentioning
confidence: 99%
“…53 Microglia and macrophages are immune cells in the brain and play a role in the inflammation response after brain injury. 3,50,54 In response to brain injury, microglia promptly acquire properties of reactive species generation, antigen presentation, phagocytosis, and the production of inflammatory mediators including IL-1, TNFα, and IL-6. 55 Proinflammatory cytokines released by necrotic cells induce subsequent neutrophil infiltration to ischemic tissue.…”
Section: Fifth Mrs2578 Treatment Exacerbated the Results Of Mnss Andmentioning
confidence: 99%
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“…Some studies documented the destructive role of microglia/macrophages in brain pathologies as highly activated microglia release a plethora of neurotoxic factors, including inflammatory cytokines, chemokines, and free radicals. In support of this view, microglia depletion has been reported to result in neuroprotection in experimental models of hemorrhagic stroke, chronic cerebral hypoperfusion, traumatic brain injury (TBI), and Alzheimer's disease (AD) . In contrast, quite a few studies documented that the removal of microglia enhanced neuroinflammation and thus exacerbated the neurological deficits after brain injuries or neurodegenerations, suggesting beneficial roles of microglia in the presence of CNS pathologies .…”
mentioning
confidence: 98%