Depletion of Immunoglobulin M Memory B Cells is Associated with Splenic Hypofunction in Inflammatory Bowel Disease

Abstract

Our findings show that peripheral IgM memory B cells are reduced in inflammatory bowel disease patients and this defect seems to be related to the impairment of splenic function.

Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection

“…The IgM memory B-cell count decreased in patients with hyposplenism, including patients with common variable immunodeficiency disease and inflammatory bowel disease (16). In addition, a high correlation was found between the pitted red cell value and IgM Articles memory B-cell count (16). These data support the use of memory B and IgM memory B-cell counts as indicators of splenic function.…”

“…Recently, the percentages of the memory B cell and IgM memory B-cell counts in the peripheral blood have been shown to correlate favorably with splenic function (15,16,20). The IgM memory B-cell count decreased in patients with hyposplenism, including patients with common variable immunodeficiency disease and inflammatory bowel disease (16). In addition, a high correlation was found between the pitted red cell value and IgM Articles memory B-cell count (16).…”

“…This method has been suggested to be a more sensitive marker than the Howell-Jolly body count in detecting splenic function; however, the involved technical complexity limits its application in clinical practice (13,19). Recently, the percentages of the memory B cell and IgM memory B-cell counts in the peripheral blood have been shown to correlate favorably with splenic function (15,16,20). The IgM memory B-cell count decreased in patients with hyposplenism, including patients with common variable immunodeficiency disease and inflammatory bowel disease (16).…”

Proximal Versus Distal Splenic Artery Embolisation for Blunt Splenic Trauma: What is the Impact on Splenic Immune Function?

“…A significant reduction or absence of IgM memory B cells is also found in patient groups with an intact spleen but known increased risk of invasive pneumococcal infection [18].…”

“…It may, therefore, represent a watershed zone which is more vulnerable than other zones to a fall in splenic perfusion pressure. Around half of the B cells in the blood express the CD27 marker and are considered memory B cells [18,19]. There are two populations of memory B cells-switched memory B cells and IgM memory B cells.…”