Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Nenke, M.A.; Rankin, Wayne; Chapman, Marianne J.; Stevens, Natalie E.; Diener, Kerrilyn R.; Hayball, John D.; Lewis, John G.; Torpy, David J.

doi:10.1111/cen.12680

Cited by 46 publications

(70 citation statements)

References 26 publications

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“…A more comprehensive understanding of the physiological response to infection is a necessary element in achieving progress. As has been described previously [15], augmentation of the delivery of cortisol to inflamed tissue is believed to be as a result of a combination of inflammatory cytokine induced HPA axis activation, in combination with rapid cleavage of corticosteroid-binding globulin (CBG) by tissue elastases [70]. An increase in the secretion of cortisol and a diminution in CBG production occur early in this process [71].…”

Section: Future Research Directionsmentioning

confidence: 99%

Adrenal Crises in Children: Perspectives and Research Directions

et al. 2018

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Adrenal crises (AC) are life-threatening physiological disturbances that occur at a rate of 5–10/100 patient years in patients with adrenal insufficiency (AI). Despite their seriousness, there is a paucity of information on the epidemiology of AC events in the paediatric population specifically, as most investigations have focused on AI and ACs in adults. Improved surveillance of AC-related morbidity and mortality should improve the delineation of AC risk overall and among different subgroups of paediatric patients with AI. Valid incidence measures are essential for this purpose and also for the evaluation of interventions aimed at reducing adverse health outcomes from ACs. However, the absence of an agreed AC definition limits the potential benefit of research and surveillance in this area. While approaches to the treatment and prevention of ACs have much in common across the lifespan, there are important differences between children and adults with regards to the physiological, psychological, and social milieu in which these events occur. Education is considered to be an essential element of AC prevention but studies have shown that ACs occur even among well-educated patients, suggesting that new strategies may be needed. In this review, we examine the current knowledge regarding AC events in children with AI; assess the existing definitions of an AC and offer a new definition for use in research and the clinic; and suggest areas for further investigation that are aimed at reducing the incidence and health impact of ACs in the paediatric age group.

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Section: Future Research Directionsmentioning

confidence: 99%

Adrenal Crises in Children: Perspectives and Research Directions

et al. 2018

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“…These DAMPs and PAMPs can also directly stimulate adrenal cortex cells that possess Toll-like receptors (TLR), resulting in ACTH-independent cortisol synthesis. In addition, paracrine routes allow the medulla to also stimulate glucocorticoid synthesis independently of ACTH to the severity of illness [16]. In septic patients, reduction in CBG levels correlates with plasma interleukin-6 (IL-6) levels [17].…”

Section: Cortisol Transport and Metabolismmentioning

confidence: 99%

Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM)

et al. 2017

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“…It's scientific name is : 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione , while it's common name is Medrol , and it's molecular formula is C 22 H 30 O 5 with 374.5 for molecular weight [1]. Methylprednisolone is quickly distributed to all body tissues like most of adrenal cortex steroids , in which move into the blood circulation and conjugated with plasma proteins , mainly with Globulin and Albumin in less ratio [2]. DOI: 10.24086/cuesj.si.2017.n2a12…”

Section: Introductionmentioning

confidence: 99%

Experimental Study for the Effect of Methyl Rednisolone on the Sexual Hormones Levels

Yaseen¹,

Al-Samarrai²,

Yasin³

2017

Cihan Univ.-Erbil Sci. J.

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Methylprednisolone is one of the steroid drugs (Glucocorticoid) , which is used in many medical conditions including allergy , ulcerative Colitis , Lupus , psoriasis , respiratory disorders and immune inhibitory. Fifty sex adult male rats weighing (225-250) gm where used, and randomly divided into four equal groups, which treated with daily by three different concentration from Methylprednisolone drug : (10,30,40) mg/kg/day. The blood samples is taken in the first and second week of dosage from all groups. The results of this study showed that the drug has obvious effect on the sexual hormones ( Testosterone hormone , LH hormone, FSH hormone and Prolactin hormone ) in sera of rats under investigation , In which the maximum change in the levels of hormones were showed in sera of groups with high dosage from drug (40 mg/kg) and the minimum change at the low dosage (20 mg/kg) . The results are indicated there is significant decrease in testosterone levels, LH and FSH the decrease is continued until the second week . As for the Prolactin hormone , the results indicated there is a significant increased and increase is continued until the second week .

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Depletion of high‐affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications

Cited by 46 publications

References 26 publications

Adrenal Crises in Children: Perspectives and Research Directions

Adrenal Crises in Children: Perspectives and Research Directions

Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM)

Experimental Study for the Effect of Methyl Rednisolone on the Sexual Hormones Levels

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