Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants
Muhammad Imtiaz Ashraf,
Joerg Mengwasser,
Anja Reutzel-Selke
et al.
Abstract:Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APCs), particularly dendritic cells (DCs), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DCs (cDCs) and APCs on the immunogenicity of skin and skin-containing VCA grafts, using mouse models o… Show more
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