Depletion of Cystine in Cystinotic Fibroblasts by Drugs Enclosed in Liposomes

Butler, J D; Tietze, Frank; Pellefigue, Francoise; Spielberg, Stephen P.; Schulman, Joseph D.

doi:10.1203/00006450-197801000-00012

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…First, pantethine may not have been absorbed by the cells. This is unlikely as earlier studies have shown that pantethine is able to elicit the depletion of cystine from cystinotic fibroblasts, leukocytes and renal cells and that this depletion is dependent upon the intracellular conversion of pantethine to cysteamine (Butler, Tietze, Pellefigue et al 1978;Orloff, Butler, Towne et al 1981;Butler & Zatz, 1983Pelle«, Smith, Thoene et al 1984). Secondly, isolated hyper¬ prolactinaemic cells may lack pantetheinase, the enzyme responsible for the catabolism of pantetheine, the reduced form of pantethine.…”

Section: Discussionmentioning

confidence: 90%

The depletion of plasma prolactin by pantethine in oestrogen-primed hyperprolactinaemic rats

Jeitner

Oliver²

1990

Journal of Endocrinology

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Pantethine was investigated for its potential to deplete prolactin in the plasma and pituitary cells of oestrogen-primed hyperprolactinaemic rats. This compound has been used in the past to deliver cysteamine systemically, through its congener pantetheine, a metabolic precursor for cysteamine. Cysteamine itself, specifically reduces plasma and pituitary prolactin. The addition of pantethine (2-10 mmol/l) to the media of isolated pituitary cells over 4 h did not appreciably alter the intracellular content of immunoreactive prolactin. Moreover, oral administration of pantethine at 0.5 and 1.0 g/kg body weight did not influence the concentration of immunoreactive plasma prolactin. However, the concentration of plasma prolactin fell by 48 and 67%, when pantethine was injected i.p. at 0.5 and 1.0 g/kg body weight, after 4 h. Intravenous administration of pantethine resulted in even greater losses of prolactin, in the order of 50 and 81% depletion for 0.5 and 1.0 g/kg body weight respectively and within 2 h of administration. However, cysteamine was found to be more efficacious than pantethine on a molar basis with regard to depleting the plasma concentration of prolactin in hyperprolactinaemic rats.

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Section: Discussionmentioning

confidence: 90%

The depletion of plasma prolactin by pantethine in oestrogen-primed hyperprolactinaemic rats

Jeitner

Oliver²

1990

Journal of Endocrinology

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“…This reaction is catalyzed by metal ions such as Cu 2+ , Fe 3+ , and Zn 2+ and is stimulated in alkaline pH (Atallah et al, 2020). To increase its stability and improve its biological effects, Cyst has been encapsulated in liposomes (Butler et al, 1978;Jaskierowicz et al, 1985;Jeitner and Oliver, 1990), cyclodextrins (Lahiani-Skiba et al, 2007), and emulsions (Gresham et al, 1971).…”

Section: Introductionmentioning

confidence: 99%

“…Their biocompatibility, biodegradability, and low toxicity make them very appropriate carriers for many drugs (Zylberberg and Matosevic, 2016). Cyst has been encapsulated in liposomes to enhance its absorption through the intestinal wall (Butler et al, 1978), its effectiveness in cystinosis (Jaskierowicz et al, 1985), and the period of prolactin depletion action (Jeitner and Oliver, 1990). To the best of our knowledge, the liposomes encapsulating Cyst were not characterized in previous studies, and the effect of encapsulation on Cyst stability was not evaluated.…”

Section: Introductionmentioning

confidence: 99%