Depleting the carboxy-terminus of human Wnt5a attenuates collagen-induced arthritis in DBA/1 mice

Cao, Wei; Niu, Menglin; Tong, Yulong; Du, Yuxuan; Lou, Weiwei; Mao, Yiyang; Dou, Yunpeng; Yuan, Huatang; Zhao, Weiming

doi:10.1016/j.bbrc.2018.09.030

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The findings that Wnt5a produced by synoviocytes promotes the differentiation and function of osteoclasts and expression of inflammatory cytokine and MMPs suggest that osteochondral destruction and inflammation can be suppressed in RA via the suppression of Wnt5a [64,179,180].…”

Section: Wnt Signaling and Musculoskeletal Disorders: Recent Findimentioning

confidence: 99%

The Regulation of Bone Metabolism and Disorders by Wnt Signaling

Maeda

Kobayashi

Koide

et al. 2019

IJMS

252

218

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Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.

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Section: Wnt Signaling and Musculoskeletal Disorders: Recent Findimentioning

confidence: 99%

The Regulation of Bone Metabolism and Disorders by Wnt Signaling

Maeda

Kobayashi

Koide

et al. 2019

IJMS

252

218

View full text Add to dashboard Cite

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“… 403 – 405 The involvement of Wnt5a produced by synoviocytes in RA suggests that suppression of Wnt5a is a potential treatment of RA. 406 , 407 Wnt5a knockout mice were resistant to RA development, presenting as reduced inflammation parameters and less cartilage destruction. 406 As Wnt5a promotes RA via ROCK signaling, ROCK inhibitor Y-27632 inhibits Wnt5a-induced RA FLS migration and reduced inflammatory cytokines IL-1β, IL-6, MMP3, MMP9 and MMP13 levels.…”

Section: Targeting Wnt Signaling In Bone Disease Treatmentmentioning

confidence: 97%

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu,

Chen,

Qian

et al. 2024

Bone Res

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Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses. In this review, we provide an update of Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases. The Wnt proteins, receptors, activators, inhibitors, and the crosstalk of Wnt signaling pathways with other signaling pathways are summarized and discussed. We mainly review Wnt signaling functions in bone formation, homeostasis, and related diseases, and summarize mouse models carrying genetic modifications of Wnt signaling components. Moreover, the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including the extracellular molecules, cytosol components, and nuclear components of Wnt signaling are reviewed. In summary, this paper reviews our current understanding of the mechanisms by which Wnt signaling regulates bone formation, homeostasis, and the efforts targeting Wnt signaling for treating bone diseases. Finally, the paper evaluates the important questions in Wnt signaling to be further explored based on the progress of new biological analytical technologies.

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