Dépistage systématique des dysglobulinémies monoclonales «asymptomatiques chez les donneurs de sang

Frequency of Monoclonal Gammapathy (‘M Components’) in 13,400 Sera from Blood Donors

“…In our previous reports [4,5] concerning systematic studies of people above 65 years of age and living in two different regions of France, we already described a different distribution of immunoglobulin classes of the M components in these two populations. Of 14 M components found among 500 subjects from Clermont-Ferrand, 11 belonged to the IgG class, 2 to the IgA and 1 to the IgM, whereas 500 subjects from Saint-Nazaire had 20 M components, 8 being IgG, 2 IgA and 10 IgM.…”

“…The distribution of heavy and light chain classes in BEMG was 13 y (11 K and 2 L) and 3 MK. This screening of a normal population allowed detection of either clinically premalignant states or the occurrence and evolution of benign essential forms of gammapathies.It is well known that monoclonal immunoglobulins (M component) [17] can be detected in serum of people apparently in good health and in the absence of any clinical and haematological signs, suggesting myeloma or Waldenstrom's disease [5,6,10,18]. These subjects must be followed over many years after the discovery of these abnormalities to determine whether the evolution is leading towards a malignant process (myeloma, Waldenstrom's macroglobulinaemia [WM] or, to the contrary, a 'benign essential monoclonal gammapathy' (BEMG).…”

Incidence of Paraproteinaemia in Blood Donors

“…The data presented by Fine et al [4][5][6] from differ ent Blood Transfusion Centres in Franceand particularly the findings in people from the St-Nazaire area [6] -suggest that the incidence of paraproteinaemia could also be somehow related to the geographical origin of the population studied.…”