Depilatory effects of certain chemicals during the first hair growth cycle in sucking mice

Panaretto, BA; Tunks, DA; Munro, SG

doi:10.1258/002367778781088431

Cited by 5 publications

(10 citation statements)

References 9 publications

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“…Reis and Tunks (1982) have shown that ethionine, an analogue of methionine, is an inhibitor of wool growth and may cause shedding of the fleece. However, in contrast to various compounds investigated by Panaretto et al (1978), it did not induce hair loss in mice during their first cycle of hair growth. In the study reported in this paper, the effects of cycloleucine and reduced glutathione were investigated in sheep in an attempt to obtain further information relevant to the mode of action of ethionine as an inhibitor of wool growth.…”

Section: Introductioncontrasting

confidence: 69%

“…Tests with sucking mice in their first hair-growth cycle were carried out, using Sydney White strain mice, as described by Panaretto et al (1978). Most groups consisted of 10 mice with five serving as untreated controls.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…In consequence, the effects of various analogues of phenylalanine and tyrosine have been investigated here in sheep and mice. These compounds are structurally related to mimosine, an effective depilatory agent in sheep ) and mice (Panaretto et al 1978).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Reis¹,

Tunks²,

Rigby³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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Sheep were given intravenous infusions of ethionine together with cycloleucine or reduced glutathione, in attempts to prevent the inhibition of wool growth by ethionine. Other sheep were given cycloleucine alone to measure effects on wool growth. Twenty-two compounds related to cystine, methionine, ethionine, lysine, phenylalanine and tyrosine were given as intravenous infusions to sheep to investigate their potential as depilatory agents. Nineteen of these compounds were also tested in mice during their first cycle of hair growth. The concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibres caused by ethionine, but reduced glutathione was ineffective. Cycloleucine weakened wool fibres, as judged subjectively, and caused a small reduction in fibre diameter. Selenocystine and selenomethionine caused some hair loss in mice but selenocystine was also toxic. Both seleno-amino acids were toxic for sheep; selenocystine was lethal at 0·025 mmol kg-o . 75 and selenomethionine at 0·09 mmol kg-O . 75 • Doses that permitted survival of sheep did not have depilatory effects. However, the presence of autophagic vacuoles in the cytoplasm of follicle bulb cells of sheep indicated that a toxic dose of selenocystine had potential depilatory activity. Other compounds investigated did not induce loss of wool or hair. Some compounds, notably 3-methylthiopropionic acid and S-(2-aminoethyl)-L-cysteine, were toxic to mice but not sheep. The methionine analogue, methoxinine (O-methyl-DL-homoserine), caused a substantial reduction in the strength of wool fibres and a prolonged alteration of the crimp pattern. It is suggested tentatively that cycloleucine inhibits methionine adenosyltransferase and thereby reduces or prevents the formation of S-adenosylethionine. The failure of various compounds related to methionine and ethionine to have any depilatory activity in sheep supports the view that ethionine influences wool growth via the formation of S-adenosylethionine.

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Section: Introductioncontrasting

confidence: 69%

Section: Experimental Animalsmentioning

confidence: 99%

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Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Reis¹,

Tunks²,

Rigby³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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“…Commencing when they were 6 days old with an average weight of 4 g, 40 mice were injected subcutaneously once daily for 3 days with a solution of L-mimosine as described by Panaretto et al (1978); the total dose of mimosine averaged 2·7 mg per mouse. Seven days after the first injection of mimosine, 20 treated mice showing at least 90 % depilation were selected.…”

Section: Methodsmentioning

confidence: 99%

“…Details of the diets and experimental treatments are given in the relevant references or in the description of each experiment. Sucking mice were maintained as described by Panaretto et al (1978).…”

Section: Experimental Procedures With Animalsmentioning

confidence: 99%

Changes in the Matrix Proteins of Wool and Mouse Hair Following the Administration of Depilatory Compounds

Gillespie¹,

Frenkel²,

Reis³

1980

Aust. Jnl. Of Bio. Sci.

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After sheep were defieeced with mimosine, cyclophosphamide or N-[5-(4-aminophenoxy)pentyl]-phthalimide, the first samples of the new growth of wool differed markedly in composition from the pretreatment samples, there being substantial reductions in the high-tyrosine proteins and increases in the high-sulfur proteins. Similar results were obtained with mice dehaired with mimosine and with sheep treated with low levels of mimosine which resulted in weakened wool rather than depilation. The composition of later samples of the regrowth wool showed progressive changes with time. The high-tyrosine proteins tended to approach the pretreatment levels, although this may take up to 12 weeks to occur, whereas the levels of high-sulfur proteins, after the initial increase, often fell below normal. In experiments involving defieecing with cyclophosphamide, the level of the latter proteins was still below normal after 3 months.The possibility that this altered protein composition of keratin fibres is characteristic of that portion of fibre first produced by a new or regenerating follicle was investigated in sheep and mice. It was found that wool follicles regenerating after plucking, and newly operating follicles in young sheep and mice, also produced wool and hair with a reduced content of high-tyrosine proteins. It is suggested, therefore, that the apparent long-term inhibition of the high-tyrosine proteins may not be the direct consequence of the administration of the chemical but rather be characteristic of normal wool and hair regrowth.Infusion of an amino acid mixture lacking methionine into the abomasum of sheep caused the growth of weak wool but did not suppress the synthesis of the high-tyrosine proteins. This is in contrast with previous findings that treatments which weaken wool also suppress high-tyrosine proteins.

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Chapter 16. Veterinary Drugs

Fisher

Chabala

Mrozik

1981

Annual Reports in Medicinal Chemistry

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Depilatory effects of certain chemicals during the first hair growth cycle in sucking mice

Cited by 5 publications

References 9 publications

Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Changes in the Matrix Proteins of Wool and Mouse Hair Following the Administration of Depilatory Compounds

Chapter 16. Veterinary Drugs

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