Depigmentation caused by phenolic detergent germicides

Kahn, Guinter

doi:10.1001/archderm.102.2.177

Cited by 55 publications

(33 citation statements)

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“…For example, skin depigmentation due to exposure to a skin-bleaching cream containing hydroquinone (HQ) (Arndt and Fitzpatrick, 1965), occupational depigmentation of the hands caused by a HQ-containing photographic developer (Frenk and Loi-Zedda, 1980;Kersey and Stevenson, 1981), occupational depigmentation caused by an o-phenylphenolcontaining microbiocide in a hospital (Kahn, 1970) and depigmentation of the hands and forearms caused by 4-tert-butylphenol in a factory manufacturing resin (Ebner et al, 1979;Gebhart et al, 1980) have been reported. Skin depigmentation was also induced in workers engaged in the manufacturing process of raspberry ketone (RK, 4-(4-hydroxyphenyl)-2-butanone) (Fukuda et al, 1998b).…”

Section: Introductionmentioning

confidence: 99%

Depigmentation of the skin induced by 4-(4-hydroxyphenyl)-2-butanol is spontaneously re-pigmented in brown and black guinea pigs

et al. 2014

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-Chemically induced depigmentation of the skin, which occurs following exposure (application or inhalation) to a depigmenting agent, is a disease with clinical findings similar to vitiligo. Recently, skin depigmentation possibly resulting from exposure to 4-(4-hydroxyphenyl)-2-butanol (HPB) was reported in humans. However, the role of HPB as the causative material of this skin depigmentation was not clear. To evaluate whether HPB has the potential for skin depigmentation, we characterized its effects on the skin of pigmented guinea pigs. Following exposure to 30% HPB 3 times/day for about 20 days, we found that obvious skin depigmentation was induced in brown and black guinea pigs. In the depigmented skin, there was a marked reduction in melanin pigment, and decreased numbers of DOPA and S-100 positive epidermal melanocytes were observed histologically. In addition, the depigmentation gradually recovered spontaneously and the number of melanocytes in the skin also increased after terminating the application of HPB. Complete re-pigmentation needed 31 to 70 days to return to the original baseline level. These data indicate that skin depigmentation is induced by the toxicity of HPB to epidermal melanocytes, and that the induced skin depigmentation can recover by terminating the application of HPB.

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Section: Introductionmentioning

confidence: 99%

Depigmentation of the skin induced by 4-(4-hydroxyphenyl)-2-butanol is spontaneously re-pigmented in brown and black guinea pigs

et al. 2014

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“…Several phenolic agents also induce skin depigmentation (27,28). These effects have been attributed to metabolic activation of phenols to various catechols in pigmented systems (5,18).…”

Section: Introductionmentioning

confidence: 99%

Semiquinone Anion Radicals of Catechol(amine)s, Catechol Estrogens, and Their Metal Ion Complexes

Kalyanaraman¹,

Felix²,

Sealy³

1985

Environmental Health Perspectives

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The characterization and identification of semiquinone radicals from catechol(amine)s and catechol estrogens by electron spin resonance spectroscopy is addressed. The use of diamagnetic metal ions, especially Mg2e and Zn2+ ions, to detect transient semiquinone radicals in biological systems and to monitor their reactions, is discussed. A brief account of the identification and reactions of quinones is also presented.

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“…Dopa staining showed melanocyte depletion. Phenol, which the patient had contact with in his occupation is well known to cause leukoderma and vitiligo 5,6,[8][9][10] . Based on these findings, chemical leukoderma was diagnosed and managed with topical corticosteroid.…”

Section: Discussionmentioning

confidence: 99%