Dependence �structure � Toxicity�of the Methyl Derivatives of Pyridine and Pyridinen-Oxide

Perspective for using 2,6-dimethylpyridine-N-oxide to reduce the toxic effect of xenobiotics in mammals ‎

“…It was established that plant biostimulants based on 2,6dimethylpyridine-N-oxide are low-toxic substances for laboratory animals. The toxicity of 2,6-dimethylpyridine-Noxide and other methyl derivatives of pyridine-N-oxide is largely due to the oxygen present in the pyridine molecule near the nitrogen atom, the lower lipophilicity, and value of charge on the nitrogen atom [11][12][13]. There are toxicity increases with a reduction in the charge on the nitrogen atom in the molecules of methyl derivatives of pyridine-N-oxide.…”

“…There are toxicity increases with a reduction in the charge on the nitrogen atom in the molecules of methyl derivatives of pyridine-N-oxide. The toxicity of complexes of pyridine-N-oxide with organic acids depends on the structure of proton-donors and can be caused by changes in the state of hydrogen bonds with oxygen N + → O and hydrogen as a result of their interaction [13]. A study of the combined effect of Ivin with pesticides of various chemical groups showed that Ivin reduces the severity of clinical signs of intoxication and acute toxicity of most of the substances tested on animals, prevented or reduced the lethality of rats observed with separate administration of toxic substances at doses corresponding to ½ and 1DL 50 [6,14].…”