Abstract:Mouse thymocytes and erythrocytes form rosettes when incubated together at 4 degrees C. The frequency is much higher when the thymocytes and erythrocytes are MHC-identical. If the indolizidine alkaloid swainsonine (SW) is present during rosette formation at concentrations of 1 microgram/ml (5.7 microM) or greater, rosette formation between MHC-identical pairs is inhibited to levels comparable to those observed for MHC-different pairs; rosette formation by MHC-different pairs is not affected. This was confirmed… Show more
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