Dependence of “apparent” magnitude on the time delay of cyclic variation of myocardial backscatter

Finch-Johnston, Ann E.; Gussak, Hiie M.; Mobley, Joel; Holland, Mark; Petrovic, Olivera; Pérez, Julio E.; Miller, James G.

doi:10.1016/s0301-5629(99)00021-6

Cited by 19 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, IBS could identify those patients most suitable for AVR before irreversible myocardial damage is realized and with the best chance of postoperative recovery and improvement. 20 …”

Section: Discussionmentioning

confidence: 99%

Severe Aortic Stenosis and Myocardial Function

et al. 2004

View full text Add to dashboard Cite

Background— The aim of this study was to assess the myocardial reflectivity pattern in severe aortic valve stenosis through the use of integrated backscatter (IBS) analysis. Patients with aortic stenosis (AS) were carefully selected in the Department of Cardiology. Methods and Results— Thirty-five subjects (AS: valve orifice ≤1 cm 2 ; 12 female; mean age, 71.8±6.2 years) and 25 healthy subjects were studied. All subjects of the study had conventional 2D-Doppler echocardiography and IBS. Backscatter signal was sampled at the septum and posterior wall levels. Patients with AS were divided into 2 groups: 16 patients with initial signs of congestive heart failure and a depressed left ventricular systolic function (DSF) (ejection fraction [EF] range, 35% to 50%) and 19 asymptomatic patients with normal left ventricular systolic function (NSF) (EF >50%). Myocardial echo intensity (pericardium related) was significantly higher at the septum and posterior wall levels in DSF than in NSF and in control subjects. IBS variation, as an expression of variation of the signal, appeared to be significantly lower in AS with DSF than in NSF and in control subjects, at both the septum and posterior wall levels. Patients with DSF underwent aortic valve replacement, and, during surgical intervention, a septal myocardial biopsy was made for evaluation of myocardium/fibrosis ratio. Abnormally increased echo intensity was detected in left ventricular pressure overload by severe aortic stenosis and correlated with increase of myocardial collagen content (operating biopsy). Conclusions— One year after aortic valve replacement, we observed a significant reduction of left ventricular mass, and, only if pericardial indexed IBS value (reduction of interstitial fibrosis) decreased, it was possible to observe an improvement of EF and of IBS variation.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe Aortic Stenosis and Myocardial Function

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The measurements of cyclic variation IBS based on the difference between average peak and average nadir value are more robust, 13 and it is likely that this approach will improve our results when applied in our laboratory. Several authors have demonstrated the potential inaccuracy of a peak-to-peak measurements, which are applied in the present study, and of the magnitude of cyclic variation, not taking in account the dependence of the "apparent" magnitude on the time delay of cyclic variation of myocardial backscatter.…”

Section: Methodological Considerations About Ultrasonic Backscatter Amentioning

confidence: 98%

Incremental Value of Ultrasonic Tissue Characterization (Backscatter) in the Evaluation of Left Ventricular Myocardial Structure and Mechanics in Essential Arterial Hypertension

et al. 2003

View full text Add to dashboard Cite

show abstract

“…This allows assessment of the magnitude of the cyclic variation, which we have taken as the difference between the average peak and average nadir values of IBS. 14 To avoid the effects of anisotropy as much as possible and to reduce phase correction, only the parasternal views were used for analysis, and region of interests were placed in the anterior septum and posterior, or inferior, wall as perpendicular as possible to the ultrasound beam and directly opposite each other whenever possible.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, many authors believe that it is necessary to make a correction for phase of the cyclic IBS. 14,15 Even in subjects with normal myocardium, there are some variations. Studies have shown wide variation in both the magnitude and phase of cyclic IBS between myocardial segments in healthy subjects.…”

mentioning

confidence: 99%

Determination of Successful Reperfusion After Thrombolysis for Acute Myocardial Infarction

et al. 2002

View full text Add to dashboard Cite

Background-The aim of the present study was to determine the use of cyclic variation in ultrasonic integrated backscatter (IBS), which is reduced in ischemic myocardium, to predict an occluded infarct-related artery (IRA) after thrombolysis for acute myocardial infarction (AMI). This is important, because patency of the IRA 90 minutes after thrombolysis has been shown to predict outcome. Methods and Results-One hundred thirteen patients with AMI had peak-to-peak cyclic IBS measured in the myocardial territory supplied by their IRA as well as a remote territory with normal function from the parasternal long-or short-axis view. This analysis took 5 to 10 minutes. Wall motion score index was assessed, and coronary angiography, to determine patency of the IRA, was performed in all patients. Cyclic IBS in the IRA territory was much lower in segments supplied by an occluded IRA (3.3 versus 4.6 dB, PϽ0.00001). Using a difference in cyclic IBS between infarcted and normal segments of 15% (or 1.5 dB) as a cutoff, the sensitivity, specificity, positive and negative predictive values to determine an occluded IRA were 92%, 75%, 81%, and 89%, respectively. Conclusions-The difference in cyclic IBS between IRA and remote normal segments, which can be analyzed rapidly, can be used to predict patency of the IRA in patients with AMI. This provides a noninvasive method to determine those patients who may require urgent invasive investigation.

show abstract

Dependence of “apparent” magnitude on the time delay of cyclic variation of myocardial backscatter

Cited by 19 publications

References 24 publications

Severe Aortic Stenosis and Myocardial Function

Severe Aortic Stenosis and Myocardial Function

Incremental Value of Ultrasonic Tissue Characterization (Backscatter) in the Evaluation of Left Ventricular Myocardial Structure and Mechanics in Essential Arterial Hypertension

Determination of Successful Reperfusion After Thrombolysis for Acute Myocardial Infarction

Contact Info

Product

Resources

About