Dependence between Cu concentration in the liver, kidneys and skeletal muscles of canine females

Abstract

Abstract:The aim of the investigations was the determination of the Cu contents in the liver, kidneys and skeletal muscles of canine females.Material for research was collected post mortem from 45 animals aged 1 to 18 years coming from the Warsaw area. The effect of the health state, age and life conditions on the distribution of copper in the investigated organs was estimated. That element was determined using the method of inductively coupled plasma-atomic emission spectrometry (ICP-AES). In the liver, the average Cu contents amounted to 24.04 mg kg -1 wet weight, in kidneys to 2.90 mg kg -1 wet weight and in muscles to 0.94 mg kg -1 wet weight. The highest values of copper content in particular tissues and organs were noted in the group of animals with neoplastic changes. In respect to the animal age the highest mean values of the copper content were noted in the oldest animals. They amounted to 30.97 mg kg -1 in the liver, 3.34 mg kg -1 in kidneys and 1.18 mg kg -1 wet weight in muscles. Considering life conditions of the dogs it was observed that the higher mean values in all the investigated organs occurred in dogs coming from the urban areas.

The Content of Copper and Molybdenum in the Liver, Kidneys, and Skeletal Muscles of Elk (Alces alces) from North-Eastern Poland

“…Most often, they manifested themselves as neurological disorders in a form of enzootic ataxia [ 14 – 16 ]. Described symptoms result from the fact that Cu is an element determining proper course of metabolic processes, like e.g., cell respiration, activity of nervous system (copper participates in the formation of neurotransmitters), building of connective tissues, and production of pigments in tissues [ 7 , 17 , 18 ]. Biological role of Cu is a result of its properties as a component or activator of enzymes such as peroxide dismutase, ceruloplasmine, cytochrome oxidase, tyrosinase, dopamine hydroxylase, and lysine oxidase.…”

“…Copper concentration in adult mammals is from 1.5 to 2.5 mg∙kg −1 body mass [ 19 , 20 ]. Due to specific anatomical features of digestive system in ruminants, there is an interaction between copper and antagonists, particularly molybdenum and sulfur, which in the rumen results in the production of thiomolybdates [ 18 ]. An important issue is the demand of rumen microflora for Cu which is lower than the demand of host’s tissues and amounts 1.57 μmol∙kg −1 of dry mass of fodder.…”

The content of selected metals in muscles of the red deer (Cervus elaphus) from Poland

“…Due to being widespread, rubidium may substitute potassium in metabolic reactions, which may disturb their proper course. Even though the importance of rubidium for animals is not clearly understood, studies performed so far have indicated that Rb may be an essential element but the margin between its necessary and toxic level is very narrow (Angelow 1994 ; Kośla et al 2002 ; Milman et al 2006 ; Skibniewska et al 2012b , 2013b ). The mean content of rubidium in muscles of analysed red deer was lower than that reported by Jarzyńska and Falandysz ( 2011a ).…”

The influence of “Hayward” kiwi fruit (Actinidia deliciosa) from organic and conventional cultivations on the content of some trace elements in the rat kidneys and assessment of copper, manganese and zinc bioavailability / Wpływ owoców kiwi “Hayward” (Actinidia deliciosa) z upraw ekologicznej i konwencjonalnej na zawartość niektórych mikroelementów w nerkach szczura i ocena biodostępności manganu, miedzi i cynku

“…There are many factors affecting the absorption of Mn, Cu and Zn, which may be both activators and inhibitors of that process. What is more, most elements demonstrate synergistic or antagonistic action towards each other [Kośla et al 2004;Skibniewska et al 2012]. It is suggested that the effect of kiwi fruits on the bioavailability of Table 1.…”

“…In the case of Cu, the liver is a better source for estimating the bioavailability of this trace element and these results will be published soon [Leontowicz et al in press]. Zinc, copper and manganese are among the elements that are considered to be essential, as their presence conditions a proper course of metabolic processes and their deficit or excess leads to serious disturbances of the health state [Kośla et al 2004;Skibniewski et al 2010, Skibniewska et al 2012]. …”